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Biomedical subjects

S G Pak

Publications and source records attributed to S G Pak.

At least 55 records · Page 3Linked to original sources
PubMed1989

[The adhesive properties of salmonellae in the dynamics of the infectious process].

In patients with toxic infections salmonellae were identified in 31% of cases. The patients were divided into two groups: the control group receiving treatment with infusion solutions and the test group treated, in addition to the usual scheme of therapy, with indomethacin in a daily dose of 150 mg. The study revealed that salmonellae isolated at the initial stages of the disease possessed highly pronounced adhesive properties. The adhesive properties of salmonellae isolated at the stage of convalescence from the patients of the test group were considerably less pronounced than those of salmonellae isolated from the same patients at the peak of the disease. In the control group no differences in the adhesive properties of salmonellae isolated from the same patients were established.

Acute Disease↗
PubMed1988

[Free-radical oxidation of blood plasma lipids in patients with acute intestinal infections].

Blood plasma free radical lipid oxidation was studied in 98 patients with acute dysentery (AD) and 64 patients with food toxinfection (FTI). Free radical lipid oxidation was assessed by the intensity of chemiluminescence and the level of lipid peroxides. Activation of blood plasma lipid peroxidation was established with relation to a clinical variant of the disease. The effect of indomethacin on the parameters of free radical lipid oxidation was noted in patients with AD and FTI.

Acute Disease↗
PubMed1988

[Dynamics of the plasma fibronectin level in patients with food poisoning].

A study was made of the influence of the level and biological activity of plasma fibronectin of phagocytosis and opsonic activity of blood plasma in 147 patients with food toxinfections depending on a period and degree of severity of a course of disease. Plasma fibronectin concentration was determined by rocket immunoelectrophoresis. Fibronectin biological activity was assessed by cold heparin precipitation. Opsonic activity of blood plasma before and after fibronectin inactivation in it was investigated using indices of phagocytosis which was studied by optical microscopy. Food toxinfections were attended by a decrease in the level and biological activity of plasma fibronectin returning to normal during therapy and convalescence. A degree of the reduction of the level of plasma fibronectin reflected the severity of a course of food toxinfections. Phagocytic insufficiency developed in food toxinfections. One of its mechanisms was a decrease in opsonic activity of plasma fibronectin as a result of the reduction of its level.

Adolescent↗
PubMed1987

[Disorders in the thrombocyte link of hemostasis during endotoxinemia and their correction with the inhibitor of prostaglandin biosynthesis, indomethacin].

After 10 minutes of endotoxin Salmonella typhimurium (1 mg/kg) injection into rabbits thrombocytopenia appeared, the aggregation and secretory function of circulating platelets reduced, the transformation of platelet forms from disk-shaped into spheroidal took place. On the surface of plasmatic membranes the pseudopodies and aggregates examining samples of PRP were observed. Indomethacin, blockator of biosynthesis of prostaglandins results in normalisation of morphofunctional properties of platelets.

Animals↗
PubMed1987

[Cellular immunity factors in salmonellosis and food toxinfections].

A complex immunological examination of 68 salmonellosis patients and 227 patients with alimentary toxinfections of unknown etiology has been made in the process of their treatment by rehydration therapy. At the acute period of the disease, irrespective of its nosologic form, cellular immunity has been suppressed. Cell-mediated immunity factors have been shown to depend on the severity of the disease.

Adolescent↗
PubMed1987

[Water-electrolyte balance and plasma corticosteroid level in patients with food poisoning and salmonellosis].

Altogether 57 patients with alimentary toxoinfections of obscure etiology and 39 patients with the gastrointestinal form of salmonellosis of average gravity were examined. Two methods were employed: rehydration and incorporation of indomethacin in the therapeutic scheme. The time course of the studied indices in the patients with salmonellosis was similar to dynamic changes in the patients with alimentary toxoinfections. The incorporation of indomethacin in the therapeutic scheme brought the indices of water-electrolyte metabolism and corticosteroid secretion more rapidly to normal.

11-Hydroxycorticosteroids↗
PubMed1985

[Indicators of cardiohemodynamics and components of the kinin system of blood plasma in patients with salmonellosis treated by various methods].

Seventy patients with salmonellosis of moderate severity were examined for cardiohemodynamics and plasma kininogenesis over time depending on the treatment. It was found that indomethacin applied in a complex of treatment measures had a beneficial effect on cardiovascular and kinin system functions in the stage of early convalescence.

Adolescent↗
PubMed1984

[Effect of indomethacin on the daily catecholamine excretion and on the rheographic and capillaroscopic indices of salmonellosis patients].

A total of 127 patients with salmonellosis were studied for the effect of the disease severity on the central and peripheral hemodynamics, and catecholamine excretion. Introduction of indomethacin into a complex of treatment measures resulted in a more rapid recovery of the parameters of the central and peripheral hemodynamics and made catecholamine excretion return to normal.

Adult↗
PubMed1983

[Nonspecific indices of cellular and humoral immunity in viral hepatitis A and B patients].

The article deals with the comparative study of the state of phagocytosis, as manifested by the ingestion of bacterial cells and by the results of the specific lupus erythematosus test, in 65 patients with acute viral hepatitis A and 45 patients with acute viral hepatitis B; these patients were also compared with respect to the presence of the markers of antigenemia and the state of their nonspecific immunity, determined by the level of serum immunoglobulins.

Adolescent↗