Search PubMed⌕ Search

Biomedical subjects

S G Mann

Publications and source records attributed to S G Mann.

25 records · Page 2Linked to original sources
PubMed1988

Prophylaxis against acid aspiration syndrome. Single oral dose of H2-antagonist on the evening before elective surgery.

We have compared famotidine 40 mg, ranitidine 300 mg and placebo given in a single oral dose at 2200 hours as the sole means of prophylaxis in 286 patients who underwent elective surgery the following day. Standardised premedication was administered and anaesthesia induced. Gastric contents were aspirated by nasogastric suction and the pH and volume measured. Median values of pH after famotidine, ranitidine and placebo were 6.17, 6.74 and 2.45 respectively; median aspirate volumes were 8, 8 and 10 ml respectively. The proportions of patients considered 'not at risk' (pH greater than 2.5) were 90% after famotidine, 91% after ranitidine and 52% after placebo. We conclude that the administration of a potent H2-antagonist in a single oral dose at night offers a convenient routine means of providing extensive prophylactic cover in patients scheduled to undergo elective surgery the following day.

Administration, Oral↗
PubMed1987

The place of famotidine in anti-ulcer therapy.

Famotidine now presents physicians in the USA and many European countries with a third option when considering H2-antagonist therapy. A dose of 40 mg in the evening decreases nocturnal gastric acidity for 10-12 hours, leaving daytime-stimulated acidity virtually unaffected. This single evening dosage regimen produces effective healing of gastric and duodenal ulceration; maintenance of healing can then be achieved satisfactorily with 20 mg in the evening. In extensive clinical studies, the adverse effect profile of famotidine is similar to placebo. Famotidine has no known drug interactions and there are no identified mechanisms by which it might be expected to produce them. Circulating plasma hormone concentrations in man are not affected by famotidine and no antiandrogenic properties have been observed in animal studies. Future potential uses of famotidine may include the treatment of haemorrhage from peptic ulcers and the healing of oesophageal ulceration.

Famotidine↗
PubMed1975

Carcinoma of the esophagus: an analysis of results and of treatment techniques.

Results of radiation therapy in 85 patients with squamous cell carcinoma of the esophagus are presented. Whereas the majority of patients with this tumor have been shown to die within the first year, occasional patients may survive longer (21.5 percent in this series); late radiation complications must therefore be maintained at a minimum. A localization technique to evaluate esophageal mobility away from the spinal cord is described.

Aortic Rupture↗
PubMed1974

Kaposi's sarcoma. Experience with ten cases.

Kaposi's sarcoma is uncommon in the U.S.A. and common in Africa. Men are affected at least 4 times more frequently than females. It occurs simultaneously with lymphomas and resembles them in several ways. Radiation therapy controls the disease well. Ten patients were seen with the disease. Most had a relatively benign course, especially the 4 women. Treatment with supervoltage irradiation and cryosurgery was effective in controlling local disease.

Aged↗