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Biomedical subjects

S G Harris

Publications and source records attributed to S G Harris.

26 records · Page 2Linked to original sources
PubMed1986

Carrier diagnosis of Duchenne muscular dystrophy using restriction fragment length polymorphisms.

Molecular probes that are tightly linked to and flank the Duchenne muscular dystrophy (DMD) locus, have been used to characterize DMD mutations and diagnose female carriers. Deletions within the Xp21 region were identified for 8 of 71 families studied. Using both DNA and CK studies, accurate (96 to 98%) carrier or noncarrier diagnoses were made for 51 of 75 females at risk in 24 families with a single affected male. DNA studies resulted in an alteration of predicted risk in 40% of the cases. Recombinant diagnostic methods are useful for carrier detection in families with one or more affected males.

Chromosome Deletion↗
PubMed1983

Arousal-induced self-awareness: an artifactual relationship?

The present research was designed to test an alternative explanation for the arousal-self-awareness link found by Wegner and Giuliano (1980). Specifically, it was suggested that the running-in-place manipulation used by Wegner and Giuliano may have increased self-awareness, not because of the increased arousal it engendered, but because of its "unusual" nature. To test this hypothesis, subjects were assigned to one of three conditions: (a) fast running (both arousing and unusual), (b) slow running (unusual but not arousing), (c) control (neither arousing nor unusual). Results supported the unusual-behavior hypothesis; subjects in both running groups, regardless of speed (and arousal), showed more self-awareness on a sentence completion form than did those subjects in the control condition. The implications of these results for self-awareness theory are considered.

Arousal↗
PubMed1980

Therapeutic and toxic plasma concentrations of digoxin in the cat.

Nonanesthetized cats of both sexes were given oral digoxin (0.011 mg/kg of body weight) 3 forms: elixir, tablet, and crushed tablet mixed with food. Mean peak plasma concentrations of digoxin were highest with the elixir (1.89 +/- 1.02 ng/ml) and lowest with the crushed tablet mixed with food (0.66 +/- 0.35 ng/ml). Male cats had significantly higher (P less than 0.10) mean plasma digoxin concentrations than did female cats. A 2nd group of nonanesthetized cats of both sexes was given digoxin elixir orally at therapeutic amounts (0.011 mg/kg) once a day for 4 consecutive days. The cumulative effect of digoxin resulted in 62% increase in the mean peak plasma concentration and 231% increase in the 24-hour plasma concentration of digoxin over the 4-day period. Male cats had a significantly (P less than 0.05) higher mean plasma digoxin concentration than did the female cats. Significant changes in the ECG were not recorded. A 3rd group of nonanesthetized cats of both sexes was given a single toxic dose (0.11 mg/kg) of digoxin elixir orally. All cats showed clinical signs of digitalis toxicosis (depression, vomiting, salivation, and anorexia) before ECG changes appeared. Alterations in the ECG were minimal; the most important changes were a slight increase in the PQ interval, an elevated ST segment, and decreased heart rate. Plasma concentrations of digoxin at the time of vomition ranged from 4.45 to 12.12 ng/ml with a mean peak plasma value of 7.37 +/- 3.61 ng/ml. The cats were clinically ill for 48 to 96 hours. A plasma digoxin concentration of 2.3 ng/ml was not toxic.

Animals↗