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Biomedical subjects

S G Cooper

Publications and source records attributed to S G Cooper.

53 records · Page 3Linked to original sources
PubMed1988

Peptic erosion of the cystic artery with massive duodenal hemorrhage: therapeutic embolization.

Two patients with massive upper gastrointestinal hemorrhage due to duodenal ulceration underwent visceral angiography. In both cases there was extravasation of contrast from the cystic artery directly into the duodenal lumen. Selective transcatheter embolization of the right hepatic artery was performed in each patient, and in both cases, hemorrhage was controlled. Transcatheter embolization is introduced as an effective therapeutic measure in this unusual entity.

Aged↗
PubMed1988

Spontaneous rupture of a congenital hepatic artery aneurysm.

A 74-year-old woman with new, but vague abdominal pain developed an intra-abdominal hemorrhage. Ultrasound and CT scans before and after this event demonstrated an acute hepatic lesion with hemorrhage into the peritoneal cavity. The patient died, and a ruptured hepatic artery aneurysm was revealed at autopsy. Hepatic artery aneurysm is uncommon, usually extra-hepatic, and, in most cases, is caused by atherosclerosis, medial degeneration, trauma, or infection. In this case, the aneurysm was intrahepatic and no underlying abnormalities of the hepatic vessels were found. We discuss the clinical scenario of patients with hepatic artery aneurysm and stress the importance of considering the diagnosis in the setting of a catastrophic abdominal event. In addition, the various diagnostic and therapeutic options are explored.

Aged↗
PubMed1988

Fluorescein labeling of lymphatic vessels for lymphangiography.

A simple technique for identification of pedal lymphatic vessels for lymphangiography was developed. A fluorescein-lidocaine mixture is injected subcutaneously into the foot, and within 20 minutes, local lymphatic vessels absorb the solution and fluoresce vividly under ultraviolet light. These labeled lymphatic channels are readily isolated and cannulated. The technique has proved highly successful, with no documented allergic complications after use in more than 1,000 cases.

Fluoresceins↗
PubMed1988

A comparison of the effects of plasma exchange and immunoadsorption on anti-insulin antibody synthesis in rabbits.

Plasma exchange (PE) and ex vivo immunoadsorption (IA) may be applicable to the removal of anti-insulin antibodies (AI-Ab) from diabetic patients. However, the removal of antibodies may prompt an increase in their rate of synthesis and an overshoot of antibody levels which may be deleterious to the patient. The effects of both PE and IA on AI-Ab synthesis were studied in a rabbit model. Rabbits were immunized with insulin and the resulting AI-Abs removed by both plasma exchange and specific immunoadsorption. Following AI-Ab removal by PE no increase in AI-Ab synthesis or antibody overshoot occurred. However a large increase in AI-Ab synthesis and overshoot occurred following specific AI-Ab removal by immunoadsorption. Despite similar reductions in AI-Ab levels by PE and IA, no increase in antibody synthesis occurred due solely to antibody removal. It is likely that antigen released from the immunoadsorbent stimulated the increase in antibody synthesis following immunoadsorption. These findings are relevant to the clinical application of both PE and IA.

Animals↗
PubMed1985

A new application of plasma exchange in insulin dependent diabetes mellitus.

An insulin dependent diabetic patient was resistant to all but central venous insulin administration. For this reason plasma exchange was tried and it restored insulin responsiveness. An anti-insulin IgG antibody was identified in the patient's plasma. Plasma exchange reduced antibody levels and these correlated with daily insulin requirements. Kinetic analysis of anti-insulin antibodies, however caused us to doubt that they were the sole cause of the problem. Although the mechanism remains unclear, plasmapheresis proved to be an effective method of treating this patient's insulin resistance.

Diabetes Mellitus, Type 1↗
PubMedDate not supplied

Hyperosmolar nonketotic coma: prevention, diagnosis, and treatment.

With the multi-faceted approach to head and neck cancer today, maintaining caloric intake by long-term enteral hyperalimentation is commonplace. Along with the tremendous advantages of this form of nutrition, the disadvantage of hyperosmolar nonketotic diabetic acidotic coma is present. Mortality rates are quoted from 40% to 70% according to the literature reviewed. Therefore, prevention is the best form of treatment. The cause, diagnosis, and treatment will be discussed.

Carcinoma, Squamous Cell↗