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Biomedical subjects

S G Clayton

Publications and source records attributed to S G Clayton.

14 recordsLinked to original sources
PubMed1977

The relation between umbilical cord tissue prostaglandin E2 levels, mode of onset of labour, fetal distress and method of delivery.

The tissue concentrations of prostaglandin E2 (PGE2) were measured by radioimmunoassay in components of the umbilical cord. The levels were significantly higher in the walls of arteries than in non-vascular tissue from the umbilical cord. The highest values were found after emergency Caesarean sections and the lowest after induced ending in normal delivery. The use of forceps and the presence of fetal distress were both associated with significantly raised tissue concentrations of PGE2.

Cesarean Section↗
PubMed1976

Studies in the involvement of prostaglandins in uterine symptomatology and pathology.

The concentrations of prostaglandin E2 and F2alpha were measured by radioimmunoassay in samples of endometrial tissue from 155 women. The results showed that the concentration of prostaglandins E2 (ng/100 mg of wet tissue; mean +/- SD) in tissue from apparently healthy women with regular menstrual cycles was 79-3 +/- 9-9 during the menstrual period. The level in the proliferative and early secretory phases fell to 11-8 +/- 4-0 and 13-3 +/- 8-3 respectively. During the late secretory phase there was a significant increase to 20-1 +/- 10-8. The corresponding values from patients with fibromyomata and without menorrhagia were similar. However, the concentration in tissue from patients with fibromyomata and menorrhagia was significantly higher (63-9 +/- 17-9) during the secretory phase of the uterine cycle. In addition, the amount was significantly higher in the groups with dysmenorrhoea (19-0 +/- 4-5 proliferative; 68-0 +/-18-15 secretory) and irregular uterine bleeding (78-3 +/- 59-0 proliferative; 87-4 +/- 64-9 secretory). The mean concentration was higher in cases of endometriosis, and significantly elevated in endometrial carcinoma. The results for prostaglandin F2alpha showed a similar pattern, but the changes were less marked in patients with irregular dysfunctional bleeding. The findings are discussed.

Dysmenorrhea↗
PubMedDate not supplied

The data processing dilemma.

With the inevitability of automation at hand, today's medical groups must face the data processing dilemma with objectivity and thoroughness. The author sketches a background of the evolution of data processing for medical groups and briefly reviews the factors involved in the decision of whether to use a service bureau or buy a computer system. The essence of this article, however, is a discussion of the development of an RFP. A detailed outline of the elements necessary to include is provided, and format, distribution, and evaluation of proposals are all addressed. In conclusion, important considerations in the final selection, negotiation, and conversion processes are presented.

Computers↗