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Biomedical subjects

S G Barber

Publications and source records attributed to S G Barber.

31 records · Page 2Linked to original sources

Cimetidine effects on prolactin release and production.

The effect of cimetidine 1600 mg. daily for three months on prolactin and related hormones is reported. Basal prolactin levels rose slightly but not significantly. There was no change in basal thyroid and sex hormone levels nor in the prolactin, gonadotrophin or thyrotrophin responses to releasing hormone stimulation. Since intravenous cimetidine induces a transient hyperprolactinemia it appears that cimetidine may facilitate release of prolactin but has no effect on its synthesis.

Adult↗

Hypopituitarism and artificial ventilation.

Anterior pituitary gland function was assessed in 50 patients maintained for more than 48 h on a mechanical ventilator. Partial hypopituitarism occurred in 7 patients which did not appear to affect survival and proved transient when subsequently re-assessed. These results indicate that the pituitary infarcts previously reported in such patients are not clinically important.

Adolescent↗

African travel.

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Cholera↗

System for long-term review of patients at risk of becoming hypothyroid. Further experience.

8 years' experience of a computer-assisted system for long-term follow-up of patients at risk of hypothyroidism shows that the system is reliable, efficient, and economical. Less than 0.1% of registered patients are now lost to follow-up and less than 2% of patients need to be seen by the medical staff each year. Changes have been made in registration procedures and in the methods of finding patient who fail to attend. Improvements in the laboratory screening of thyroid function have also been introduced. The need to follow-up patients already under treatment with thyroxine has been recognised and the importance of a reliable system is reaffirmed.

Computers↗

Cramps, thirst and hypertension in hemodialysis patients -- the influence of dialyzate sodium concentration.

The effect of increasing dialyzate sodium concentration from 130 to 136 mmoles/l on the incidence of muscle cramps in patients on regular dialysis treatment is assessed. This change was found to be effective in markedly reducing the incidence of cramp at the cost of a slight rise in the complaint of thirst. Mean arterial pressure rose slightly but significantly and exchangeable sodium was increased to levels comparable to those measured during 1969, when with twice weekly dialysis hypertension was a problem. It is concluded that dialyzate sodium concentration may with benefit be increased to 136 mmoles/l, provided that blood pressure is carefully monitored.

Blood Pressure↗

Aeromedical evacuations in Papua New Guinea--a case for routine oxygen supplementation in developing countries.

Aeromedical evacuations in developing Third World countries lack the technological support available in developed countries. 125 hospital admissions from such flights over a four-month period in Papua New Guinea have been analysed to show the pattern of medical conditions and flight altitudes involved. In general, the overall pattern reflects the range of medical problems seen in many other developing countries. 36 percent of all patients were deemed to be at risk of hypoxia; on flights below an altitude of 8000 feet (2440m.) this proportion was 50 percent. Supplementary oxygen (but not 100% oxygen) given routinely to all patients would benefit many without handicapping the remainder.

Adolescent↗