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Biomedical subjects

S Fukuda

Publications and source records attributed to S Fukuda.

At least 127 records · Page 7Linked to original sources
PubMed2001

[Nasal allergies in Kushiro].

A clinical study of 107 patients with nasal allergies who were treated at Kushiro General Hospital between April 1998 and March 2000 was performed. Radioallergosorbent tests (RAST), X-rays, and nasal smears for the detection of eosinophilia were performed to obtain a diagnosis of nasal allergy. The patients (50 males, 57 females) ranged in age from 3 to 71 years. The RAST was positive for timothy in 22.4% of the patients, 14.0% for birch and 12.1% for mugwort. The most common pollinosis allergen in the Kushiro area was grass pollen. Other pollinosis allergens were birch pollen and mugwort pollen. We measured the daily count of dispersed birch pollen and timothy pollen in Kushiro and Sapporo. Birch pollen and timothy pollen was dispersed earlier in Kushiro than in Sapporo. Nasal allergies in the Kushiro area appear to be related to local characteristics, such as climate and geographical features.

Adolescent↗
PubMed2001

[Utility of OAE screener (GSI 70) for the evaluation of distortion product otoacoustic emissions].

The purpose of this study was to investigate the ability of the OAE screener GSI 70 to evaluate of cochlea function in neonates, infants and adults. Distortion product otoacoustic emissions (DPOAEs) were measured using the GSI 70 DPOAE Analyzer and evaluated in 123 human ears between December 1999 and June 2000. We performed the following four general clinical tests to determine the reliability of the GSI 70: 1) comparison of DPOAE levels measured using the ILO 92 and the GSI 70 in 55 adult ears, 2) comparison of DPOAE levels measured using the GSI 70 and hearing levels in 55 adult ears, 3) comparison of DPOAE levels measured using the GSI 70 and ABR levels in 45 neonate and infant ears, and 4) evaluation of the utility of DPOAE measurements obtained using the GSI 70 in functional deafness cases. The following results were obtained: 1) DPOAE levels measured with the ILO 92 and the GSI 70 were closely correlated (correlation coefficient, 0.773 at 2 kHz and 0.813 at 4 kHz). 2) The sensitivity of the GSI 70 in adult ears confirmed to have normal hearing was 80% at 2 kHz and 100% at 4 kHz; the specificity of hearing-impaired ears was 94% at 2 kHz and 94% at 4 kHz. 3) The sensitivity of the GSI 70 in normal neonate and infant ears with normal hearing was 100% at 2 kHz and 100% at 4 kHz; the specificity of hearing-impaired neonate and infant ears was 97% at 2 kHz and 94% at 4 kHz. 4) All of the functionally deaf ears showed excellent DPOAE responses. Examinations using the GSI 70 DPOAE analyzer were very easy and fast. Also, the results were highly reliable, with the exception of one adult who was classified as having normal hearing in an out-of-scale hearing level at 2 kHz. We suggest that specific criteria be established for the clinical usage of the GSI 70 in performing objective hearing evaluations.

Adolescent↗
PubMed2001

[EDAS (encephalo-duro-arterio-synangiosis) for occlusive/stenotic cerebrovascular disease].

The efficacy of encephalo-duro-arterio-synangiosis (EDAS) using superficial temporal artery was evaluated for the treatment of the occlusive/stenotic cerebrovascular disease. Nine patients with the occlusive/stenotic cerebrovascular disease underwent EDAS in our hospital. The mean follow-up period was 6.6 months. Postoperative angiography showed no collateral formation via EDAS in any of the nine patients. We analyzed the following points: 1) operative procedure, 2) follow up period after surgery, 3) preoperative cerebral blood flow, and 4) age of the patients. Results showed that EDAS as a treatment of occlusive/stenotic cerebrovascular disease was not effective. This study failed to reinforce the suggestion that indirect extracranial/intracranial bypass surgery is effective as the treatment of occlusive/stenotic cerebrovascular disease.

Adult↗
PubMed2001

[Three cases of advanced gastric cancer resected after successful treatment with the novel oral anticancer drug TS-1].

We operated on 3 patients with advanced gastric cancer after successful treatment with novel oral 5-fluorouracil derivatives (TS-1). In all 3 patients, gastrointestinal fiberscopy revealed a considerable reduction in the tumor after oral administration of TS-1 in our clinic. Case 1 underwent surgery after an interval of 1 day following oral administration of TS-1 for 18 days. Pathologically, no cancer cells were found in the resected stomach and a few cancer cells were found only in resected lymph nodes. In case 2, who underwent surgery after an interval of 7 days following oral administration of TS-1 for 14 days, a few cancer cells were found only in the submucosal layer of the stomach and no viable cancer cells remained in the metastasized lymph nodes. In case 3, who underwent surgery after an interval of 11 days following administration of TS-1 for 26 days, scattered cancer cells, mostly fibrotic, were found as far as the subserosal layer. The pathological effectiveness of chemotherapy was grade 2 or 3 in each case. Case 2 and 3 followed a satisfactory postoperative course; however, case 1 suddenly had endotoxinemia on the 7th postoperative day. Although the patient had temporary multiple organ failure, he recovered eventually. All 3 patients have been well without any signs of recurrence for more than a year after surgery.

Administration, Oral↗
PubMed2001

[Recurrent angina due to high grade re-stenosis of the left subclavian artery after coronary artery bypass grafting in a patient on hemodialysis for chronic renal failure: report of a case].

A 49-year-old woman on hemodialysis for chronic renal failure was admitted to our hospital with chest pain. She had undergone quadruple coronary artery bypass grafting (CABG) including a left internal thoracic to left anterior descending coronary artery anastomosis 9 months earlier. The blood flow through the left internal thoracic artery had decreased due to high grade stenosis at the proximal portion of the left subclavian artery, and recurrent angina had developed. She was treated by the placement of Palmaz biliary stents in the left subclavian artery, but re-stenosis occurred after 9 months, causing recurrent angina again. There fore, an operation was proposed and bypass grafting from the descending aorta to the left subclavian artery was successfully performed, resulting in complete resolution of her recurrent angina. This case serves to reinforce that patients on dialysis must be carefully followed up after CABG.

Angina Pectoris↗
PubMed2001

[Delayed traumatic diaphragmatic hernia diagnosed by magnetic resonance imaging and direct coronal computed tomography: report of a case].

A 59-year-old woman was admitted to our hospital with abdominal symptoms. A diagnosis of delayed traumatic diaphragmatic hernia was made from the findings of a plain X-ray film, magnetic resonance imaging (MRI) and computed tomography (CT). We successfully performed repair of the diaphragm via abdominal approach. Thus, MRI and direct coronal CT can be very useful for establishing a diagnosis of traumatic diaphragmatic hernia.

Female↗
PubMed2001

Inflammatory cytokines and antigen-responsive mononuclear cells in peripheral blood of cattle infected with Salmonella takoradi.

To determine the immunological response in lactating dairy cows infected with Salmonella (S.) Takoradi, the relationships among distributions of peripheral blood mononuclear cell (PBMC) subpopulations, endotoxin concentrations and dynamics of inflammatory cytokines in blood were investigated. The ratio of CD4+ T cells to CD8+ T cells was significantly lower in the affected cattle than in the control cattle (p<0.05) to decrease in the number of CD4+ T cells in the infected cattle. In contrast, the numbers of gammadeltaT cells, MHC class II-positive cells were significantly higher in the affected cattle than in the control cattle (p<0.01 respectively). Endotoxemia was found in all but one of the affected cattle. Serum IL-1 and IL-6 bioactivities were significantly higher in the affected cattle than in the control cattle (IL-1, p<0.05; IL-6. p<0.01). Serum TNF-alpha activities and levels were not detected in the control and affected cattle. The activities of proinflammatory cytokines determined by the bioassay are important to the relationships between concentration of endotoxin, cytokines and clinical signs. such as leukocytosis, leukopenia, fever or bacterial shedding. Serum IL-2 levels were lower in the affected cattle than in the control cattle. Serum IFN-y was not detected in the affected cattle except one. These results by the ELISA seemed to reflect the condition of subpopulation in the PBMCs from the shedding cattle. The present results suggest that cellular immunity is suppressed while the humoral immunity is activated in acute bovine salmonellosis.

Animals↗
PubMed2001

[Surgical treatment of chronic pulmonary thromboembolism caused by a cavernous hemangioma at the lower limb].

A 48-years old man complained of dyspnea and was admitted to the hospital. Chest enhanced CT confirmed the presence of the thrombus in the pulmonary artery. Cardiac catheterization showed severe pulmonary hypertension (mean PAP 75 mmHg). ATIII level, protein C and S antigen were within normal range. Anticardiolipin antibody and lupus anti-coagulant determination were negative. He was diagnosed as chronic pulmonary thromboembolism, and underwent pulmonary thromboendarterectomy via median sternotomy under deep hypothermic intermittent circulatory arrest. At the same time IVC filter was inserted. The origin of the thrombus was not detected before operation, but after surgery, MR angiography of total body showed a cavernous hemangioma at left lower limb. We speculated this lesion was the origin of pulmonary embolism.

Chronic Disease↗
PubMed2001

[Retinal hazard from blue light emitting diode].

PURPOSE: To compare the effect of exposure time from a blue(460 nm) light emitting diode(LED) on the morphology of the outer retina and determine conditions where damage occurs. MATERIALS AND METHODS: Young adult rhesus monkeys were anesthetized, and received blue LED exposure from a modified slit-lamp. A 3 mm beam of 0.85 mW was imaged onto the retina through a lens positioned before the cornea and exposure damage was determined at time intervals for 12 to 90 min. Fundus photography, fluorescein angiography(FAG), retinal tomography(HRT), and s-cone electororetinogram(S-ERG) were recorded at baseline, 2, and 30 days. RESULTS: Two days after 40 min exposure, there was a grey, discolored region, which was over-fluorescent in FAG, and an incresse in HRT and S-ERG corresponding to the site which was exposed to LED light. In histological examination at 30 days, the LED had caused produced a marked disruption of the disks of photoreceptor cells, damaged retinal pigment epithelium(RPE) apical villi, and a loss of RPE melanin after 90 min exposure. CONCLUSION: A threshold level was found around 40 min. This morphological damage may impair function and continuous exposure to blue light is potentially dangerous to vision.

Animals↗
PubMed2001

[Two cases of reoperative coronary bypass grafting through a small left thoracotomy].

A reoperation by a MIDCAB (minimally invasive direct coronary artery bypass) was performed on 2 patients, including one who had undergone a surgical repair of a left ventricular rupture and another who had undergone a coronary artery bypass operation. In both patients, the left internal thoracic artery was isolated by a left small thoracotomy and then was anastomosed to the LAD (left anterior descending artery). One patient showed stenosis at the site of anastomosis and thus required coronary arterioplasty postoperatively, but was discharged without any further complications. When performing a reoperation by MIDCAB, complications such as injuries to the heart and patent graft during surgery and postoperative complications can be minimized by only performing a bypass to LAD. Such a bypass is usually sufficient in cases in which either marked adhesion is expected in the area of the circumflex artery or if anastomosable branches are not available in the area of the circumflex artery. This surgical technique was found to be an effective modality for a reoperation of the coronary artery, if suitable cases are carefully selected.

Aged↗
PubMed2001

[Factors in popularizing home nutritional therapy (HNT) in Japan-analysis of nurse's awareness].

Home nutritional therapy (HNT) is not popular in Japan as compared with American countries. The purpose of this study was to clarify the role of nurses in popularizing HNT. We sent out questionnaires to 469 nurses working at the O University affiliated Hospital, and got 265 responses. As a result, the following two factors were considered to affect the popularization of HNT. 1. Nurses had only a superficial knowledge of the activities of the nutrition support team (NST), and medical care by NST had not been spread. 2. In HNT, there were several gaps between ideals and the real role of nurses.

Awareness↗