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Biomedical subjects

S Fukuda

Publications and source records attributed to S Fukuda.

At least 847 records · Page 47Linked to original sources
PubMed1976

[Bacteriolgical survey on Bordetella bronchiseptica in various animal species (author's transl)].

Bordetella bronchiseptica was examined on the respiratory tract of mice, rats, Mongolian gerbils, golden hamsters, guinea pigs, rabbits, household dogs and cats and cynomolgus monkeys imported from Asian countries. The organisms were detected in rats, guinea pigs, rabbits, dogs, cats and monkeys, but not in mice, Mongolian gerbils and golden hamsters. In rats, the organisms were isolated from 7 of 25 breeding colonies, and isolation rates ranged from 10.0 to 61.3% by colonies. In guinea pigs, 22 of 60 breeding colonies were positive, showing 6.7 to 58.2% in isolation rates. Two groups of rabbits were examined, one was collected from many non-closed colonies of small size and another was obtained from 3 closed colonies of large size consisting of more than 100 rabbits. Isolation rates were 3.0% in the former and 66.8% in the latter. The organisms were also detected in 5.3% of dogs and 3.2% of cats, respectively. Isolation rate of the organisms in the trachea of 48 healthy monkeys was 6.3%, but in 39 monkeys with pneumonic lesions, 16 (41.0%) harbored the organisms in their lungs.

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PubMed1975

Studies on the inhibition of experimental liver fibrosis. 2. The mechanism of the inhibition of liver fibrosis of rats due to carbon tetrachloride by elastase.

In the previous experiments, it was demonstrated that high purity elastase extracted from porcine pancreas remarkably inhibits liver fibrosis of rats having chronic liver injury caused by carbon tetrachloride. This time, with the purpose to clarify the mechanism of inhibition of liver fibrosis by elastase, comparative study was made on the activity of lysosomal enzymes by measuring beta-glucuronidase, cathepsin and collagenolytic activity, with the rats administered with elastase and with those untreated, during the period of development of liver fibrosis and the recovery from it. In addition to it, in vitro experiments were made by having elastase act on the substrate comprising mixed collagen of acid soluble and neutral soluble collagens extracted from the skin of guinea pigs and by observing collagen components by disc electrophoresis. With any lysosomal enzymes, no marked difference was noticed between elastase group and non-administered group and thus the possibility of inhibition of liver fibrosis through activation of lysosomal enzyme by elastase was denied. The results of disc electrophoretic observation of the performance of elastase on collagen revealed that beta-component of collagen is disappeared but alpha-component remained. From the above, inhibition of liver fibrosis by elastase may be due to direct affection of elastase to telopeptide portion of collagen.

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