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Biomedical subjects

S Fukuda

Publications and source records attributed to S Fukuda.

At least 811 records · Page 45Linked to original sources
PubMed1979

Specific immunotherapy for non-curatively resected gastric cancer.

The prognosis of patients with advanced gastric cancer treated with non-curative resection is very poor. In order to improve patient prognosis, we have tried specific immunotherapy as an adjunct to surgery since January 1968. Sixty-two patients with gastric cancer underwent non-curative resection during the period of this study. Twenty-eight of these patients were treated with specific immunotherapy after surgery, and 34 patients received no additional therapy. The five year survival rate was 35 per cent in the former group, and zero in the latter. No significant difference in the degree of tumor extension and invasion was noted between the two patient groups. We concluded that specific immunotherapy as an adjunct to non-curative resection for advanced cancer is worthy of further study.

Adenocarcinoma↗
PubMed1979

Evidence that dog kidney is an endogenous source of histidine.

Net production or utilization (Qmet) of histidine by the kidney was evaluation or utilization (Qmet) of histidine by the kidney was evaluated in 11 normal and 8 chronically uremic female dogs during intravenous infusion, first of half-normal saline and then an amino acid solution containing L-histidine. Also, Qmet for histidine, alanine, beta-alanine, and carnosine (beta-alanyl-L-histidine) was determined during infusion of half-normal saline and then carnosine into the renal artery in seven normal dogs. During infusion of half-normal saline, Qmet histidine, calculated from the plasma data, was significantly positive in normal but not uremic dogs. Qmet histidine correlated with creatinine clearance. In uremic dogs, plasma histidine was decreased possibly due to decreased renal production and increased urinary excretion. Qmet histidine, calculated from the whole blood data during infusion of half-normal saline, was positive but not significantly so. During carnosine infusion, there was significant utilization of carnosine, and histidine production increased. Thus during fasting, the dog kidney appears to produce histidine, and histidine production increases with carnosine infusion. Hydrolysis of carnosine, possibly by carnosinase, may be a source of histidine released by the dog kidney.

Amino Acids↗
PubMed1979

Maturation process of secondary ossification centers in the rat and assessment of bone age.

The maturation process from the appearance to the fusion of the secondary ossification centers of extremities was studied in Wistar rats aged 0 to 134 weeks. The examination of the secondary ossification centers made by radiography. The assessment of the stage of development was made in accordance with the criteria proposed by Ohwada and Sutow. The secondary ossification center was found to be take one of the following three types of maturation processes : (1) the acute ossification, (2) the delayed ossification, and (3) the incomplete ossification. No fusion was observed up to 134 weeks in certain epiphyses of the rat. This type of ossification designated as the incomplete ossification may be specific to the mouse and rat. The relative lengths of time required for appearance and fusion in the average prospective life were obtained for the rat. They were compared with those of the mouse and man. The relative length of time necessary for maturity of the secondary ossification centers was shown to be the shortest in the rat and the longest in man. The results suggested that the rat may reach maturity in the bone age at 17 to 21 weeks of age. The rat at this age may be regarded as being adult corresponding to age 17 weeks in mice and 18 to 24 years in man.

Age Determination by Skeleton↗
PubMed1979

[The measurement of the placenta, umbilical cord and components of amniotic fluid in beagle dogs].

The body weight of newborns, the weight of placenta, the length of umbilical cord and the content of urobilinogen, gulcose, protein, pH, keton body in amniotic fluid were investigated with samples from 16 litters of beagles. The mean body weight of newborn, weight of placenta and length of umbilical cord were 258.0 +/- 44.6 g (85 samples), 48.5 +/- 8.5 g (85 samples) and 11.0 +/- 2.7 cm (52 samples), respectively without any sex difference. The significant correlation were recognized between the weight of placenta and the body weight of newborn, between the length of umbilical cord and the body weight of newborn and between the weight of placenta and the length of umbical cord (P less than 0.01).

Amniotic Fluid↗
PubMed1979

Effects of unilateral and bilateral invasion of thalamic pulvinar for pain relief.

Thalamic pulvinotomy has been performed on 32 patients in severe chronic pain and a follow-up study was made. Among 10 patients with whom unilateral invasion was made, 4 were "excellent" in relieving pain, 2 "good", 2 "fair" and 2 "poor". Among 22 cases of bilateral invasion 17 were "excellent", 2 were "good", and 3 were "poor". Thus, in the cases of bilateral invasion effects of the operation were more prominent than in the cases of unilateral invasion. Further, transient psychic symptoms following the operation has been analysed in relation to position of pulvinar destruction and to underlying diseases.

Adolescent↗
PubMed1979

Experimental and clinical studies on toxicity of xenogeneic tumor-specific immune ribonucleic acid.

To learn the toxicity of xenogeneic tumor-specific immune ribonucleic acid (I-RNA), experimental and clinical studies were carried out. Experimentally, doses of 30 mg/kg, 15 mg/kg, 7.5 mg/kg or 3.75 mg/kg of xenogeneic I-RNA extracted from lymphoid tissues of rabbits sensitized with 105,000 Xg sediments of human gastric carcinoma tissue were injected intraperitoneally into Wistar rats once a day for 30 days. During the period of the study, changes of physiological and biochemical values were examined. In addition, pathological study was made for each organ after the I-RNA administration. There was no death during the study. In the groups of high dose administration, there were poor increase in the body weight, elevation of GOT, GPT and LDH, findings of vacuolar degeneration of hepatic cells, and increase of mesangial matrix and polynuclear glomerulus. Throughout the experiment, the groups given 7.5 mg/kg and 3.75 mg/kg of I-RNA showed no significant difference from control groups. Clinically, 31 cases treated with passive immunotherapy with allogeneic lymphocytes, preincubated with xenogeneic I-RNA, were examined retrospectively for the difference in hematological and biochemical data before and after the therapy. One case showed a transient mild febrile reaction after the therapy. There was no significant difference in hematological and biochemical data. Pathological findings in 3 autopsies after the treatment were reported.

Adult↗
PubMed1979

The development of hepatogenic potency in the endoderm of quail embryos.

Hepatogenic potency of the endoderm is detectable in the anterior half of the endoderm of quail embryos older than 2-somite stage when endodermal fragments are cultured with or without heterologous chick mesenchymes, in the coelomic cavity of 3-day chick embryos. On the other hand, the posterior half of the endoderm never has hepatogenic potency. The hepatogenic potency of the endoderm is gradually stabilised with increasing age. However, expression of hepatogenesis can be affected when the endoderm is associated with inductively active digestive tract mesenchymes. Mesenchyme taken from the presumptive cardiac region ('cardiac' mesenchyme) of chick embryos is necessary for the uncommitted anterior endoderm to acquire hepatogenic potency, and this effect is specific for the 'cardiac' mesenchyme. The 'cardiac' mesenchyme, however, fails to induce hepatic epithelium in the allantoic endoderm, which can differentiate heterotypically when cultured in combination with digestive tract mesenchymes. The evidence presented in this study suggests that the effect of 'cardiac' mesenchyme on the acquisition of hepatogenic potency in the endoderm is limited.

Animals↗
PubMed1979

Studies on regional inhibition of carbonic anhydrase by sulpiride in rat brain.

Sulpiride is an antipsychotic which possesses the free sulfonamide radical. From the viewpoint of this phenomenon, the in vitro inhibitory effect of sulpiride on carbonic anhydrase (CAH) was investigated. CAH inhibition was studied in eleven regions of the rat brain. The distribution of sulpiride was estimated on the basis of these findings.

Animals↗
PubMed1978

Hepatic parenchyma, biliary ducts and gall bladder forming potency in the hepatic primordium in the quail embryo.

Differentiation potency of the hepatic primordium isolated from 21- to 35-somite stage quail embryos was examined by the transplantation in the coelomic cavity of the chick embryo. The hepatic primordium differentiates into hepatic parenchyma, intra- and extrahepatic bile ducts, and gall bladder. The hepatic parenchyma and two types of biliary ducts can differentiate from any fragment of the hepatic primordium divided at craniocaudal or proximodistal levels, while the gall bladder develops mainly from the proximal area of the primordium. These results indicate that the presumptive areas of hepatic parenchyma and biliary ducts are not arranged in a mosaic way in the young primordium, whereas the presumptive area of the gall bladder is restricted. Isolated hepatic primordial endoderm was found to differentiate to the epithelia of the hepatic parenchyma, bile ducts, and gall bladder under the influence of heterologous mesenchyme.

Animals↗
PubMed1978

Significance of pathognomonic features of normal-pressure hydrocephalus on computerized tomography.

In some patients with congenital or acquired hydrocephalus, a low-density area is seen around the lateral ventricle on computerized tomography. Above all, in patients with normal-pressure hydrocephalus following subarachnoid hemorrhage, there appears a specific low-density area which is fan-shaped and irregular and which extends from the bilateral anterior horns to the frontal pole. This disappears or decreases with a VP shunt. Improvement of clinical symptoms is proportional to the degree of disappearance of the low-density area. The essential part of the occurrence of symptoms in patients with normal-pressure hydrocephalus depends upon a low-density area on CT.

Brain Neoplasms↗