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Biomedical subjects

S Fujino

Publications and source records attributed to S Fujino.

At least 91 records · Page 5Linked to original sources
PubMed1994

Drug eruption caused by recombinant human G-CSF.

Two types of recombinant human granulocyte colony-stimulating factor (rhG-CSF) are available, and equally used for mitigation of neutropenia. One is a glycosylated natural product from mammalian cells, and the other a non-glycosylated form from Escherichia coli. Though only minimal adverse effects have been reported for both, we treated two patients with rhG-CSF-induced systemic eruption. Based on these patients, the following should be noted: 1) drug eruption may occur in both types of rhG-CSF without detectable antibodies, 2) intradermal test is useful for determination of the causal drug, and 3) if one rhG-CSF product causes eruption, the alternative one may possibly be safe and effective.

Adjuvants, Immunologic↗
PubMed1994

[Evaluation of serum thrombomodulin in patients with interstitial pneumonia].

We encountered a 63-year-old man whose dry cough due to interstitial pneumonia had been successfully with an anti-thrombin drug, argatroban, which was given to treat exacerbated Buerger's disease. We therefore prospectively evaluated fibrinogen, fibrin-degradating product D-dimer, thrombin anti-thrombin III complex, and plasmin anti-plasmin complex in patients with interstitisal lung diseases. In a preliminary study, we found that some patients actually had elevated levels of these markers. These findings suggested that increased coagulability was involved in the pathophysiology of interstitial pneumonia. In this study, we measured the levels of serum-soluble thrombomodulin as a marker of endothelial cell damages that lead to hemostasis. We found that serum levels of thrombomodulin were high in about 35% of patients with sarcoidosis, interstitial pneumonia associated with collagen diseases, or idiopathic interstitial pneumonia. Furthermore, these levels decreased as the patients' conditions improved. Although further evaluation is needed, these results suggest that endothelial cell damage and hemostasis are involved in the pathophysiology of interstitial pneumonia.

Adult↗
PubMed1994

[Thoracoscopic treatment of mediastinal thymic cyst].

A mediastinal thymic cyst was excised under thoracoscope in a 66 year-old man. Mass lesion was noted in the left anterior mediastinum on chest X-p during a screening examination. Based on the findings of the chest CT and MRI, the mass was diagnosed as a cyst containing low fat and low protein fluid without solid tissue. This lesion was diagnosed as a mediastinal thymic cyst. Under general anesthesia, the thoracoscopy was inserted to the left thoracic cavity. Then, the cyst was resected sharply and bluntly with pair of scissors, while electric coagulation was performed as needed. In cases of mediastinal thymic cyst, it is possible to completely resect the cyst by thoracoscopic treatment, causing minimal surgical invasiveness. Considering that a few thymic cysts are combined with malignant tumor, complete resection of the lesion is required in the treatment of thymic cyst.

Aged↗
PubMed1994

[Pulmonary hypertension in aortic valve disease].

144 surgical patients with isolated aortic valve disease were reviewed to determine the incidence and the mechanism of pulmonary hypertension (PH). The hemodynamic data revealed PH (pulmonary artery systolic pressure of 40 mmHg or more) in 18 patients (12.6%). There was a positive correlation between left ventricular end-diastolic pressure (LVEDP) and pulmonary artery pressure. After operation the pulmonary artery pressure normalized in all cases but 2 patients in early post-operative period. In patients with aortic stenosis with PH, LVEDP/LVEDVI ratio was higher than that of patients without PH, which showed left ventricular diastolic dysfunction. In patients with aortic regurgitation with PH, the cause of elevated LVEDP was not only severe long-standing regurgitation with ventricular dysfunction, but also the imbalancement of compensation by dilated ventricle with preserved left ventricular function.

Adult↗
PubMed1994

[True aneurysm of mitral valve secondary to aortic valvular infective endocarditis].

A case of the mitral valve aneurysm with aortic valvular infective endocarditis is reported. A 30-year-old male who had the history of Streptococcus viridans endocarditis underwent aortic and mitral valve replacement. The aortic valve was bicuspid and had the perforation in its non-coronary cusp, and histology in its specimen showed post-inflammatory vascularization and disorganization of architecture. A gigantic aneurysm was visible in the anterior leaflet of the mitral valve, but both anterior and posterior leaflets had no inflammatory change in histology. In this case, the "jet" of blood produced by aortic valve perforation involved the mitral valve. This aneurysmal change was so called "jet lesion" secondary to aortic valve endocarditis.

Adult↗
PubMed1994

[Anomalous origin of the left coronary artery from the pulmonary artery with rheumatic mitral stenosis--a successful surgical case].

A 43-year-old woman in whom anomalous origin of the left coronary artery from the pulmonary artery, associated with rheumatic mitral stenosis, was surgically corrected. She underwent aortic implantation of anomalous left coronary artery and mitral valve replacement. It was feasible to obtain a sufficient length of the left main trunk excising a large cuff of pulmonary artery wall surrounding the ostium of anomalous left coronary artery, without transecting pulmonary artery. This surgical case is first reported about BWG syndrome associated with rheumatic valvular disease.

Adult↗
PubMed1993

Studies of a key protein in the mechanism of the excitation-contraction coupling process of frog skeletal muscle, using phenylglyoxal.

The excitation-contraction (E-C) coupling process in single twitch fibres from frog toe muscle was inhibited selectively by phenylglyoxal (PGO), a specific guanidyl modifying reagent. A new protein (31.5 kDa), which has PGO-binding ability and seems to play a key role in the E-C coupling process, was solubilized from transverse tubule membrane-junctional sarcoplasmic reticulum complexes (TTM-JSR) of frog skeletal muscles, using 14C-PGO. The monoclonal antibody against this protein applied extracellularly inhibited the E-C coupling process of the single fibres. This protein appears to constitute the very first step of input for E-C coupling. It is considered to behave as an indispensable part of an 'electrometer' to measure membrane potentials. Therefore, the name 'electrometrin' is suggested for the new protein.

Animals↗
PubMed1993

[A case of diffuse panbronchiolitis associated with tracheomalacia].

A 71-year-old male had suffered from cough with purulent sputum. He was admitted to our hospital because of worsening of his symptoms. The chest X-ray film showed diffuse nodular shadows and emphysematous changes in both lung fields. Transbronchial lung biopsy demonstrated findings compatible with diffuse panbronchiolitis (DPB). Bronchoscopy showed the tracheal lumen was sagittaly narrowed and membranous portion was protruded into the lumen. The trachea completely collapsed when coughing. His disease was diagnosed as saber-sheath type tracheomalacia (Johnson III). Tracheomalacia was reported to be observed in 0.9% of patients examined by bronchoscopy. The dominant type of tracheomalacia is crescent type, and saber-sheath type is rare. Chronic airway inflammation with DPB might have exacerbated the tracheomalacia in this case.

Aged↗
PubMed1993

A new technique of tricuspid valve replacement for Ebstein's anomaly.

For surgical management of Ebstein's anomaly, a new technique of tricuspid valve replacement on the true annulus, avoiding injury to the conduction system, has been developed. At operation, the valve fixation sutures are placed around the true annulus except for a part of Koch's triangle. A 3 x 3 cm xenograft patch is sutured to cover the atrioventricular node and bundle of His. The remainder of the valve fixation sutures in Koch's triangle are placed only on the patch to prevent conduction injury, and the valve fixation annulus is completed. This new technique has been applied to three patients and has preserved atrioventricular conductivity well in all cases. It is concluded that this procedure of tricuspid replacement on the true annulus can be safely applied and is remarkably effective in preventing atrioventricular conduction disturbance.

Arrhythmias, Cardiac↗
PubMed1993

[Changes in corneal astigmatism with aging].

Change in physiologic corneal astigmatism due to aging was studied. A series of 868 cases (1,660 eyes) was evaluated. These eyes were divided into 6 groups by age; A) below 40 years, B) in the 40's, C) in the 50's, D) in the 60's, E) in the 70's, and F) over 80. Corneal astigmatism was examined with an autokeratometer. In Group A, 88.5% had with-the-rule astigmatism (WTR), whereas only 3.7% had against-the-rule astigmatism (ATR). The cylindrical diopter (CD) of WTR was 1.29 +/- 0.73 D, which was significantly the largest among the groups. In Group C, WTR decreased to 55.9% and ATR increased to 22.9%. The CD of WTR also decreased to 0.85 +/- 0.47 D. In Group E, WTR was 31.4% and ATR was 49.3%. The CD of ATR increased to 0.88 +/- 0.70 D. In Group F, WTR was 19.9%, whereas ATR was 65.9%. The CD of ATR was 1.48 +/- 0.88 D, which was the largest among the groups. As such, WTR was dominant at younger ages, and ATR increased with aging at older ages. The CD of WTR decreased, and ATR increased, with aging.

Adult↗
PubMed1993

[Tetralogy of Fallot with absent pulmonary valve--a successful surgical case at 40 days after birth].

A markedly symptomatic patient with tetralogy of Fallot and absent pulmonary valve underwent operation at 40 days after birth. The baby had severe cardiopulmonary insufficiency at neonatal period and needed surgical intervention. The operation is consisted of patch closure of ventricular septal defect, partial resection of dilated pulmonary artery, and right ventricular outflow reconstruction with unicusped prosthetic patch. The patient is growing and is well more than 2 years and 8 months after operation.

Echocardiography↗
PubMed1993

[A report of successful surgical management of ASD, VSD and PDA associated with partial DiGeorge syndrome in infant].

We report an infantile male case of ASD, VSD and PDA associated with DiGeorge syndrome. The patient who was 58-day old presented the partial deficiency of cell-mediated immunity and normocalcemia before the admission to our hospital. We made semi-emergent operation because of increasing of lung congestion caused by repetitional infection of upper respiratory tract. Direct closure of the ASD, patch closure of the VSD and ligation of the PDA were performed successfully. He was suffered from severe pneumonia caused by MRSA in early postoperative stage. It was effective to give antibiotics and gamma-globulins.

DiGeorge Syndrome↗
PubMed1992

Difference between effects of chlorpromazine and perphenazine on microsomal phospholipids and enzyme activities in rat liver.

The effects of acute administration of chlorpromazine (CPZ) and perphenazine (PPZ) on hepatic microsomal phospholipids (PLs) and enzyme activities in the male rat were examined in order to elucidate the relationship between individual PLs and drug-metabolizing activity. Cytochrome P-450 and aniline (AN) hydroxylation activity were initially decreased in CPZ-treated rats, but cytochrome P-450 subsequently recovered to a level not significantly different from the control and AN hydroxylation was markedly increased, while in PPZ-treated rats, they remained depressed. CPZ increased the activities of glycerophosphate acyltransferase (GPA) and choline phosphotransferase (CPT), while PPZ increased the activities of phosphatidate cytidylyltransferase (PCT), phosphatidate phosphohydrolase (PPH) and CPT. Concurrently, CPZ raised microsomal phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine-inositol (PSI) and sphingomyelin (SM), while PPZ increased PC and PE, but did not affect the levels of PSI and SM. Acyl components of phospholipids were also modified. CPZ significantly decreased the ratio of saturated to unsaturated fatty acids, particularly in the PC and PE fractions, while the effect of PPZ was only slight. The results imply that an increase of AN hydroxylation activity may involve the incorporation of unsaturated fatty acids into enzyme-associated PC and PE.

Aniline Hydroxylase↗
PubMed1992

An experimental study on direct revascularization of bronchial circulation by microvascular anastomosis.

The effects of direct revascularization of the bronchial artery after bronchoplasty were estimated by laser Doppler velocimetry and india ink injection in dogs. Bronchoplastic surgery at the right main bronchus was performed in all dogs, and the bronchial artery was reconstructed using the internal thoracic artery in the reconstruction group. The mucosal blood flow was measured at the distal side of the anastomosis. India ink was injected into the aorta in the nonreconstruction group and into the internal thoracic artery in the reconstruction group. The peripheral blood flow had diminished immediately after surgeries to 59% of the baseline value and took 14 days to recover to the baseline value in the nonreconstruction group. However, in the reconstruction group, the blood flow recovered at once to 78% of the baseline value and had returned to that value in 5 days. Statistically significant differences were noted between the groups from just after operation to day 7. India ink data confirmed these findings. In the nonreconstruction group, no ink was observed in the peripheral bronchial vessels on day 3; it was noted in part of the vessels on day 7 and in most on day 14. On the other hand, a relatively large number of vessels were stained just after operation in the reconstruction group. Thus reconstruction of the bronchial artery by means of the anastomosis with the internal thoracic artery can be said to be a useful and effective method for preventing airway ischemia.

Anastomosis, Surgical↗