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Biomedical subjects

S Fujimura

Publications and source records attributed to S Fujimura.

At least 415 records · Page 23Linked to original sources
PubMed1976

An epidemic of acute hemorrhagic conjunctivitis in Sendai area, 1973-1974.

In 1973 and 1974, an epidemic of acute hemorrhagic conjunctivitis (AHC) with a tendency of less frequent conjunctival hemorrhage occurred among the staff of the National Railways and their family in Sendai area. Four strains of AHC virus and 4 strains, 1 of type 7 and 3 of type 8, of adenoviruses were isolated from 22 conjunctival swabs of the patients. Thirty-six (66%) out of 55 cases examined were proved serologically to be of AHC virus infection, and 7 cases (13%) were of adenovirus infection. Clinically, infrequent association of hemorrhagic conjunctivitis was most remarkable. Only 10 cases (28%) had detectable signs of hemorrhagic conjunctivitis. There were no substantial changes in antigenicity and optimum temperature for virus multiplication between prototype and isolated strains. The isolated strains, however, seemed to be less neutralizable and less producible at 29 degrees C than prototype strain.

Acute Disease↗
PubMed1975

Myocardial and plasma levels of adenosine 3':5'-cyclic phosphate. Studies in experimental myocardial ischemia.

Alterations in myocardial and plasma levels of adenosine 3':5'-cyclic phosphate (cyclic AMP) were studied following clamping of the aorta or coronary artery occlusion in 30 dogs. Plasma cyclic APM levels increased markedly after thoracotomy but returned to control levels two hours later. Complete arrest of aortic flow (clamping) induced a significant early increase in the myocardial cyclic AMP levels of all animals studied. No increase was noted following pretreatment with propranolol or sham-occlusion. After localized coronary occlusion, only modest and insignificant changes occurred in plasma cyclic AMP levels in anesthetized animals and also in conscious dogs. The present study suggests that adrenergically mediated changes in tissue cyclic AMP content are an early manifestation of both generalized and local myocardial ischemia, while the plasma cyclic AMP level is a relatively insensitive indicator of small coronary occlusions.

Animals↗
PubMed1975

Morphological differentiation of cultured mouse glioblastoma cells induced by dibutyryl cyclic adenosine monophosphate.

A culture line of mouse glioblastoma cells changed morphologically to differentiated astrocyte-like cells when cultured in medium with dibutyryl cyclic adenosine monophosphate and theophylline. Morphological alteration occurred within only 5 hr when 3 mM dibutyryl cyclic adenosine monophosphate and 1 mM theophylline were used, and in 1 day when 1 mM theophylline were used. Cells showing this morphological change reverted completely to immature cells when they were transferred to medium without these two chemicals. Addition of 1 or 3 mM dibutyryl cyclic guanosine monophosphate with 1 mM theophylline to the medium also induced development of cytoplasmic processes from these cells and the cells became stellate, although the cytoplasmic processes were not as long or as numerous as those induced by dibutyryl cyclic adenosine monophosphate, and the altered cells could not be referred to as differentiated glia cells. Sodium butyrate induced morphological alterations similar to those induced by dibutyryl cyclic guanosine monophosphate, but fewer cells showed these alterations. Addition of cyclic adenosine monophosphate or cyclic guanosine monophosphate in the presence of theophylline or addition of theophylline alone did not induce morphological changes of the cells.

Animals↗
PubMed1974

Occurrence of a complex form of staphylokinase in the course of cultivation of Staphylococcus aureus.

Proteins in the culture supernatant of Staphylococcus aureus PS 47 were subjected to Sephadex chromatography. In the early stage of the cultivation, staphylokinase appeared to have a molecular weight of 15,000 and in the later stage it appeared to have a molecular weight of 320,000. The staphylokinase having a lower molecular weight (type A) converted into one having a higher value (type B) during the course of cultivation. It was demonstrated that conversion of type A into type B took place in vitro (monitored by gel filtration after the two types of staphylokinases were mixed), and it was observed that type B reverted to type A when type B was treated with KCl or detergent. Type B seems to be a complex form of type A and some high-molecular-weight substance.

Antigens, Bacterial↗