Search PubMed⌕ Search

Biomedical subjects

S Fujimoto

Publications and source records attributed to S Fujimoto.

At least 1,081 records · Page 60Linked to original sources
PubMed1978

[Possible roles of prostaglandins in the hypothalamus (author's transl)].

The last decade has been the most prolific and stimulating period in the area of prostaglandin (PG) study. Since PGs were found in the hypothalamus and cerebrospinal fluid, and were released from the central nervous system (CNS) spontaneously and in response to chemical or electric stimulation, many investigators have been engaged in studying their effects in the CNS. In fact, PGs have a wide range of pharmacological actions in the CNS. Relatively large doses of PGs have to be given centrally to produce some effects. On the other hand, some types of PGs, when applied centrally in doses of a few ng, stimulate the hypothalamus or the pituitary gland to increase secretion of hypothalamic and anterior and also posterior pituitary hormones. Physiological investigations of PGs have been aided by the use of inhibitors of their synthesis; aspirin, indomethacin etc. These compounds inhibit secretion of the hormones from the hypothalamus as well as the pituitary, suggesting that endogenous PGs exert a functional role for the hormone secretion. To produce fever, PGEs have to act on the preoptic anterior hypothalamus, and aspirin and indomethacin decrease fever produced by pyrogens but not PGEs. Pyrogens produce fever by increasing synthesis and release of PGEs. Hypothalamic PGEs play a role as a central transmitter or modulator in temperature regulation.

Adrenocorticotropic Hormone↗
PubMed1978

Effects of intracerebroventricular prostaglandins E2 and F2alpha on the urine outflow, and a possible role of pgE2 as a modulator.

Effects of intracerebroventricularly (i.c.v.) injected PGE2 and PGF2alpha on the urine outflow were studied in ethanol-anesthetized rats. PGE2 and PGF2alpha, when injected i.c.v., caused diuresis which was followed by antidiuresis. Phentolamine, when perfused i.c.v., was an antidiuretic and inhibited the diuretic and antidiuretic effects of PGE2. Diphloretin phosphate inhibited both effects of PGE2. Polyphloretin phosphate (PPP) and propranolol blocked completely the PGE2-induced diuresis and consequently remarkable antidiuresis was observed after the combined treatments with PGE2 and PPP or propranolol. When PGE2 was perfused i.c.v., a sustained diuresis was obtained and antidiuretic effects of noradrenaline, gamma-aminobutyric acid and L-glutamate were potentiated, inhibited and unaffected by the perfusion with PGE2, respectively. It was indicated that the antidiuretic effect of PGE2 could be dissociated from the diuretic effect and that both effects were mediated through adrenergic mechanisms. The present result also suggested that central PGE2 might act as a modulator of some neurotransmitters involved in water metabolism.

Animals↗
PubMed1978

Effects of centrally affecting drugs on the diuretic and antidiuretic actions of intracerebroventricular prostaglandin E2.

Effects of centrally affecting drugs on the diuretic and antidiuretic actions of intracerebroventricularly (i.c.v.) injected prostaglandin (PG) E2 in ethanol-anaesthetized rats were studied. PGE2, when injected i.c.v. at a dose of 1 nmole, produced diuresis followed by antidiuresis. When morphine (0.1 mM) was perfused i.c.v., urine outflow decreased and neither diuretic nor antidiuretic effects of i.c.v. PGE2 was apparent. The perfusions with picrotoxin, gamma-aminobutyric acid and L-glutamate inhibited either the diuretic or the antidiuretic effect of PGE2. On the other hand, when pentobarbital, diazepam, isoniazid and strychnine were perfused i.c.v., the diuretic action of PGE2 was diminished and antidiuresis in response to PGE2 remained unchanged. These results suggested that the diuretic and antidiuretic effects of PGE2 could be separated. The developed of the diuretic effect of PGE2 was completely blocked by amitriptyline and antidiuresis was increased. In rats pretreated i.c.v. with reserpine, the diuretic effect of PGE2 was prolonged and antidiuresis in response to PGE2 was not observed. An antidiuretic action of i.c.v. norepinephrine was not varied by reserpine. Mechanisms for both effects of PGE2 are discussed.

Amitriptyline↗
PubMed1978

Longterm favorable effect of oxygen administration on a patient with primary pulmonary hypertension.

A 17-year-old girl with primary pulmonary hypertension was treated with longterm administration of oxygen. Oxygen was delivered only at night for eight hours daily. Her clinical status has been improved for more than 17 months. Cardiac catheterization revealed almost 50 percent reduction of pulmonary vascular resistance. This is the first known report of successful treatment of primary pulmonary hypertension with oxygen administration.

Adolescent↗
PubMed1978

The source of progesterone in rabbit blastocysts.

High levels of progesterone were found in the blastocysts, uterine fluid and sera of normal pregnant rabbits on Days 6 and 7 of pregnancy. Very little progesterone (less than 2% of control) was present in bilaterally ovariectomized rabbits in which pregnancy was maintained by the administration of medroxyprogesterone acetate. The results demonstrate that the rabbit blastocyst is provided with large amounts of progesterone derived from the maternal ovaries.

Animals↗
PubMed1978

The effect of ovarian wedge resection and incision on circulating gonadotropin in patients with polycystic ovarian disease.

Wedge resection (WR) was performed in 12 women with polycystic ovarian disease (PCOD), and Incision was done in 4 PCOD patients without any resection of ovarian tissue. Serum LH, FSH, estradiol-17beta (E2), progesterone, and urinary 17 ketosteroid (17KS) were measured serially before and after surgery. Neither WR nor Incision had any effect on FSH levels. Serum LH levels which had been hypergonadotropic preoperatively, became markedly lower 7--14 days after surgery in 12 wedge-resected and 2 incised patients. Within 7 days after WR there was a significant fall of E2 and a decrease of 17KS. In addition to those hormonal changes observed after WR, BBT charts turned out to be diphasic after the oral administration of dydrogesterone (Duphaston) in 12 out of 17 PCOD patients. The present data suggest that the reduction of the serum LH, induced by an interaction between the ovarian steroidogenesis and the suprapituitary mechanisms, might be involved in the occurrence of ovulation after WR in PCOD patients.

17-Ketosteroids↗
PubMed1978

Chromosomal anomalies of preimplantation rabbit blastocysts and human artificial abortuses in relation to maternal age.

It is well established that in man there is a higher frequency of chromosomally and phenotypically abnormal offspring and a decline in fertility as maternal age increases. This paper describes preliminary work on some chromosomal aspects of 5- and 6-day old preimplantation rabbit embryos, with attention to maternal age dependence of chromosome anomalies. Chromosome preparations were made by a modification of the method of Shaver and Carr (1967). Two trisomic blastocysts were observed among 50 embryos examined from 10 does of 40 to 52 months of age, that is, 45XY with an extra submetacentric chromosome and 45XX with an extra acrocentric chromosome. In man, three trisomies (47XX, G+, 47XX, D+, and 47XY, G+), one monosomy (45X or 45XX, C-) and one double trisomy (48XY, C+, E+ or 48XXY, E+) were karyotyped out of 32 early induced abortuses from women older than 40. Among the 22, induced abortuses analyzed from women between 35 and 39, one trisomic embryo of 47XY, G+ was observed.

Abortion, Induced↗
PubMed1978

Serum angiotensin converting enzyme level in bronchial asthma.

Using hippuryl-L-histidyl-L-leucine as a substrate analogue, serum angiotensin converting enzyme (ACE) was spectrophotometrically estimated in patients with bronchial asthma. The mean level of asthmatic patients was significantly lower than that of the control subjects. The reduced serum ACE activities did not change during an acute asthmatic attack. Significantly lower levels of serum ACE occurred in patients with chronic asthma than in those who only suffered with occasional asthma. Serum ACE activity was not reduced when the patients were taking steroids. Serum ACE activity could not be correlated with either the systolic blood pressure or the diastolic blood pressure of our asthmatic patients. However, serum ACE activity was correlated with the serum beta-globulin fraction in asthmatic patients.

Asthma↗