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Biomedical subjects

S Frost

Publications and source records attributed to S Frost.

At least 37 records · Page 2Linked to original sources
PubMed1997

Features of the auditory development of the short-tailed Brazilian opossum, Monodelphis domestica: evoked responses, neonatal vocalizations and synapses in the inferior colliculus.

The onset of hearing in anesthetized South American opossums (Monodelphis domestica) was determined by the measurement of evoked potentials to click stimuli from the vertex of the skull immediately over the inferior colliculus. Evoked potentials were first recorded at postnatal day 24 at a threshold of 83 dB SPL; thresholds declined over subsequent weeks to below 58 dB at 40 days. Isolation calls emitted by the pups had stereotypic spectra with peaks at near 13 kHz and an octave higher. Such calls declined in frequency by day 32 and were not emitted at day 40. The peak frequency of the calls matched very closely the best frequency of hearing of adult Monodelphis. The number of synapses in the inferior colliculus increased at day 26; when plotted in relation to the number of cells, synaptic density increased steeply from day 27 after the animal had begun to hear. This suggests that environmental sound has a potent effect on the development of synapses in the auditory system.

Acoustic Stimulation↗
PubMed1997

Cognitive processing and trait anxiety in typically developing children: evidence for an interpretation bias.

In this study the authors examined whether increases in children's levels of self-reported trait anxiety would be related to their interpretation of ambiguous stimuli. By using the Revised Children's Manifest Anxiety Scale (C. R. Reynolds & B. O. Richmond, 1985), the authors obtained measurements of anxiety for 40 children ages 7 and 9 years. Interpretation of ambiguous stimuli was measured by using a pictorial homophone task, where homophones could be interpreted as either threatening or neutral. Results showed that children's interpretations of homophones was significantly predicted by level of anxiety. Increases in levels of trait anxiety were positively associated with threatening interpretations of homophones.

Anxiety↗
PubMed1995

Hepatitis C infection, cryoglobulinemia, and vasculitic neuropathy. Treatment with interferon alfa: case report and literature review.

A patient with mononeuropathy multiplex, hepatitis C viral infection, and mixed cryoglobulinemia had axonal degeneration by EMG and vasculitis of the epineurial vessels on sural nerve biopsy. There was no evidence of viral particles in the nerve by immunofluorescence. Treatment with interferon alfa improved the patient's symptoms and cleared the hepatitis C viral RNA and cryoglobulins from the serum.

Adult↗
PubMed1989

Organized personal care--an effective choice for managing diabetes in general practice.

A system of diabetic review was introduced in two Southampton training practices in March 1985. Each partner, with the help of the practice nurse, retained responsibility for review of their own diabetic patients. During the study period (1984-86) 213 diabetics remained with the practices. In 1984 there were 94 non-insulin dependent patients who were not receiving hospital outpatient care. Over the study period there was an increase in the surveillance of blood glucose, blood pressure, weight, urine (for protein), fundi, visual acuity and feet for this group so that in 1986 between 79% and 89% of patients were having these parameters checked at least annually. More complications were found and more referrals for specialist evaluation were made. There was a trend towards transfer of care from the hospital to the general practitioner, and the proportion of non-insulin dependent diabetic patients receiving their care entirely from general practice increased from 22% to 60% over the period. There was a small increase in the workload of the general practitioners and a considerable contribution to care was made by the practice nurses. It is concluded that structured personal diabetic care based on a nurse coordinated service is a satisfactory alternative to the 'specialist' general practitioner mini-clinic model.

Aged↗
PubMed1987

The potential of computed tomography in visualising structures inside the metal cup in surface-replacement total hip arthroplasty.

Computed tomography (CT) was employed to evaluate the femoral component of the prosthesis in surface-replacement total hip arthroplasty in seven patients suffering from rheumatoid arthritis. Image reconstruction using the high frequency filter resulted in an image of the cement-bone interface inside the cup which allowed the detection of bone resorption. This new application of CT could prove to be a valuable complement to conventional methods in the radiological assessment of metal cup arthroplasties.

Adult↗
PubMed1982

Bleomycin pulmonary toxicity: production of fibrosis by bithiazole-terminal amine and terminal amine moieties of bleomycin A2.

We have previously demonstrated that endotracheal administration of the terminal amines of several bleomycins, when administered as the free amines, produce pulmonary fibrosis of severity comparable to the intact drug. In the present report, bleomycin A2 and its sulfonium ion-containing terminal substituents, with and without the bithiazole rings, were administered to mice endotracheally. The incidence and severity of epithelial metaplasia was greater with the intact drug in comparison to the terminal substituents. In contrast, the terminal substituents and intact drug produced similar degrees of fibrosis. These results underscore the importance of the variable bleomycin terminal substituents in the pathogenesis of pulmonary fibrosis.

Animals↗
PubMedDate not supplied

Acute abdominal aortic occlusion.

Acute occlusion of the infrarenal abdominal aorta is a catastrophic event requiring early recognition and intervention if permanent disability is to be decreased or avoided. While traditional causes of occlusion (saddle embolus and thrombosis) are the most frequent, vasculitis and hypercoagulable states have recently been suggested as etiologies. This article presents three cases of acute abdominal aortic occlusion from different mechanisms and reviews the literature concerning presentation and management.

Acute Disease↗
PubMedDate not supplied

Epilepsy: a journey.

Epilepsy is a tendency to have recurrent fits or seizures, and for most people is an uncomfortable and socially unacceptable thing to witness. It is estimated that 420,000 people in the UK will develop the condition in one form or another, with the risk of death three times higher than in the general population. There are over forty different types of seizure; each type presents itself differently from one person to another. However, the cause of the epilepsy is always the same; it is due to abnormal electrical activity within the brain (Fenwick and Fenwick 1996). The aim of this Learning Unit is to improve the understanding of epilepsy among nurses.

Anticonvulsants↗
PubMedDate not supplied

Health care support workers in the critical care setting.

The 1999/2000 winter demands on the NHS have once again highlighted deficits in UK critical care provision (Daily Telegraph, 2000; London Evening Standard, 2000) Recent years have seen the development of the role of health care support workers in the NHS; some critical care units now employ health care support workers This research examined the views of critical care unit staff on the introduction of health care support workers into the critical care unit It is concluded that the role is viable within the setting of this study A framework is outlined that could form the basis for a critical care health care support worker training programme

Attitude of Health Personnel↗