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Biomedical subjects

S Friedman

Publications and source records attributed to S Friedman.

609 records · Page 34Linked to original sources
PubMedDate not supplied

Dynamic parameters of glycine metabolism in diabetic human pregnancy measured by [15N]glycine and gas chromatography-mass spectrometry.

This study presents kinetic parameters of glycine metabolism during pregnancy and the influence of fuel availability in the maternal compartment. The effect of gestational diabetes mellitus (diet treated) and pre-gestational diabetes mellitus (diet and insulin treated), accompanied by increased fetal growth on [15N]glycine kinetic parameters, compared to normal pregnancies with normal fetal growth, has been determined. This process was measured by administration of a single-dose of [15N]glycine to post-absorptive normal and diabetic pregnant women during the third trimester of pregnancy. Gas chromatography-mass spectrometry was used to determine the 15N enrichment of plasma glycine, and to calculate the pool sizes, turnover rate constants, fluxes and metabolic clearance rates. Glycine pool sizes in pre-gestational diabetes were significantly larger than those in normal pregnancy and gestational diabetes. Glycine turnover rate constants and metabolic clearance rates were not significantly different between the normal pregnant women and the two diabetic groups of pregnant women. Glycine fluxes were significantly higher in the pre-gestational diabetic pregnant women than in gestational diabetes and normal pregnancy. The pre-gestational diabetic pregnant women delivered fetuses with higher birth weights than the other two groups.

Adult↗
PubMedDate not supplied

Prevalence of congenital anomalies and neonatal complications in the offspring of diabetic mothers in Israel.

The prevalence of diabetes in pregnancy and its fetal and perinatal consequences in a large population of Israeli pregnant women during the last decade are presented. The study population consisted of 878 gestational diabetic women, 132 pre-gestational diabetic women, and 380 healthy pregnant women who served as controls. Minor congenital anomalies ranging between 19.4 and 20.5%, major congenital anomalies between 1.80 and 6.82%, and neonatal complications, such as macrosomia (5.6-25.0%), hypoglycemia (0.9-7.8%), hyperbilirubinemia (8.2-16.7%), hypocalcemia (2.7-5.5%) and polycythemia (3.8-13.3%), were observed in the study population. Despite meticulous maternal glucose control, we could not entirely eliminate fetal and neonatal complications. The definition of the normal and abnormal fetal intrauterine metabolic environment remains to be elucidated.

Congenital Abnormalities↗
PubMedDate not supplied

The fetus of the diabetic mother: growth, malformations and methods of surveillance by ultrasonography--the Beilinson Medical Center experience.

Some important issues continue to plague the perinatologist caring for the pregnant diabetic. These issues deal principally with fetal surveillance to prevent macrosomia, idiopathic prematurity and multiple congenital anomalies. In this report particular emphasis is placed upon the role of transvaginal and transabdominal ultrasonography in monitoring fetal growth and in early detection of congenital anomalies. New modalities, such as Doppler flow measurements and nuclear magnetic resonance imaging, are described in addition to our experience at the Beilinson Medical Center in monitoring diabetic pregnancies by these modalities.

Congenital Abnormalities↗
PubMedDate not supplied

Hydralazine-induced hepatitis in pregnancy.

During 1983, 38 patients with pregnancy-induced hypertension were treated with hydralazine-apresoline (1-hydrazinophthalazine). During the course of their treatment, five of these patients showed evidence of the HELLP syndrome described by Weinstein (hemolysis, thrombocytopenia, and elevated liver enzymes). Evidence is presented on the role of hydralazine in producing hepatocellular damage. Liver function is compromised during the natural course of pregnancy-induced hypertension, and 5-10% of preeclamptic patients develop the HELLP syndrome. In many places hydralazine is the drug of choice in the treatment of pregnancy-induced hypertension.

Chemical and Drug Induced Liver Injury↗
PubMedDate not supplied

Fetomaternal outcome in pregnancies after total correction of the tetralogy of Fallot.

Nine pregnancies in five women after total correction of the tetralogy of Fallot (TOF) are reported. In four women, further corrective operations were necessary in order to achieve class I functional capacity. Our management of the patients during pregnancy, labor and puerperium is described, and some simple rules are stressed. We suggest that improved feto-maternal outcome, in our series, may be related to the recorrective surgery of residual defects after one stage total correction of TOF, as well as to close surveillance by monitoring of perinatal and hemodynamic aspects of these patients.

Adult↗
PubMedDate not supplied

Surrogate parenting.

The surrogate parenting is a process by which a couple can obtain a baby after the husband's sperm is artificially inseminated into another woman who has agreed to carry the pregnancy at term and to relinquish any claim to the infant. In this paper the author illustrates the structure of an SP program with particular reference to the legal, ethical and medical aspects of this reproductive technique.

Adoption↗