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Biomedical subjects

S Friedman

Publications and source records attributed to S Friedman.

At least 469 records · Page 26Linked to original sources
PubMed1976

The parasitic ecology of the rodent mite, Myobia musculi. III. Lesions in certain host strains.

Mice (C57BL/6N) from a commercial production colony with ulcerative skin lesions were shown to have low level infestations with Myobia musculi. Lesions were abolished by exposure to dichlorvos-impregnated plastic strips. Experimental reinfestation with M musculi resulted in prompt exacerbation of lesions in previously healed mice. Exacerbated lesions were again abolished by subsequent dichlorvos treatments. The histopathology of such lesions was shown to be similar to those in cats allergic to Otodectes cynotis; and a morphologic basis for an allergic interpretation of the myobic lesions in the C57BL/6 mice was described. Other evidence supporting an allergic interpretation included the heritability of susceptibility to such lesions in certain strains, the paucity of mites required for extensive lesions, the chronic duration of infestation required prior to lesion development, and the apparent anamnesis to experimental reinfestation. A large commercial hybrid production colony requiring C57BL/6 females had an incidence of ulcerative lesions (in females) of 20% and depressed reproductive indices. Two 48 hour treatments at an interval of 14 days utilizing dichlorvos-impregnated strips (1 square inch per cage) abolished lesions and elevated production indices for a period of 5 months.

Animals↗
PubMed1975

Mechanical precipitation of hemoglobin köln.

Hb Köln (beta 98 Val leads to Met) was found to precipitate rapidly during mechanical shaking. The rate of precipitation of Hb Köln is 5-6 times faster than that of Hb S. The kinetics of precipitation of the patient's hemolysate, which is a mixture of Hb Köln and Hb A, showed a biphasic curve indicating that Hb Köln precipitates independently from Hb A. The instability of Hb Köln may be attributed to the conformational change in the vicinity of heme. The mechanical shaking may be used as a new method for detection and quantitation of hemoglobin Köln and other unstable hemoglobins.

Chemical Precipitation↗
PubMed1975

A rapid test for sickle hemoglobin.

Vigorous shaking of oxygenated sickle hemoglobin (Hb S) in solution causes precipitation of the hemoglobin. This unusual property of Hb S forms the basis of a simple test for the presence of Hb S. Comparison of results of this test with those from cellulose acetate electrophoresis in blood samples from 599 patients showed no false-positive or false-negative results. The group tested included 55 persons with sickling disorders and 47 others with unusual hemoglobin patterns. This test may be used to confirm the presence of Hb S or to establish the diagnosis of sickling disorders rapidly in the clinic or at the bedside.

Anemia, Sickle Cell↗
PubMed1975

First reported successful management of Serratia marcescens bacteremia after open heart surgery in a child.

A 7 and one-half yr-old girl developed bacteremia from S. marcescens following debanding of the pulmonary artery and closure of multiple ventricular septal defects with a Dacron patch and multiple Teflon pledgets. The site of entry was probably a radial arterial catheter left in place for 8 days. Infection was eradicated by a combination of gentamicin and carbenicillin over a 4-wk period. Of 12 cases of postoperative Serratia bacteremia in adults following valve replacement, only four survived. Antibiotics of proven effectiveness against the specific isolated Serratia strain, prompt therapy sustained for 6 wk offers the prospect for cure of this serious complication of cardiac surgery.

Anti-Bacterial Agents↗
PubMed1975

Project Re-ed: increase in self-esteem as measured by the Coopersmith Inventory.

A group of boys and girls (9 to 15 yr. of age) who were identified as emotionally disturbed and in residential enrollment at a short-term (2 to 15 mo.) high-impact residential treatment center displayed a significant gain on the Coopersmith Self-esteem Inventory. Of the 59 children 37 showed a gain; 19 showed a decrease.

Adolescent↗
PubMed1975

The parasitic ecology of the rodent mite Myobia musculi. II. Genetic factors.

Mice of 4 strains, C57BL/6J, CD2F1(BALB/cCum female times DBA/2Cum male), BRVR/SrCr and BSVS/SrCr, were monospecifically infested with an equal number of Myobia musculi. A single skin field (7mm diam) in the dorsal midline slightly posterior to the eyes was used for periodic observation of mite populations. Mite counts were made by direct microscopic examination of the skin field at 10-da intervals. Data were obtained on mice thus infested and observed for 130 da. Between-strain comparisons differed significantly in the number of Myobia maintained in all cases except between BRVR and BSVS strains. Factors bearing on heritable differences in susceptibility were discussed.

Animals↗
PubMed1975

A simple technique of laparoscopic tubal sterilization.

In the last several years the use of laparoscopy in gynecological practice has become very popular. It is indicated for a number of conditions. However, sterilization of the female has been the main indication for laparoscopy and will remain so until more efficient and reversible techniques are developed. A simple technique of laparoscopic tubal sterilization is presented. In the opinion of the authors it offers several advantages over other methods. Only one instrument is used and only one type of electrical current applied. A small portion of the fallopian tube is removed and the surrounding tissue--the tube and mesosalpinx-- is sufficiently cauterized to secure hemostasis. The histological quality of the removed specimen is excellent. Finally, less than 2 cm of fallopian tube is destroyed, providing an excellent opportunity for reanastomosis.

Female↗