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Biomedical subjects

S Friedman

Publications and source records attributed to S Friedman.

At least 361 records · Page 20Linked to original sources
PubMed1985

Idiopathic fibrosing alveolitis: a review with emphasis on ultrastructural and immunohistochemical features.

Fibrosing alveolitis is a usually chronic pulmonary disease affecting middle-aged men and women and causing progressive dyspnea. This review discusses the nosologic, etiologic, immunopathogenic, histologic, immunohistochemical and ultrastructural features of this condition. A hypothesis is presented suggesting microvascular damage as the primary pathologic change in cases associated with collagen vascular diseases and viral pneumonia.

Acquired Immunodeficiency Syndrome↗
PubMed1985

The turnkey approach: a new way to finance capital improvements.

Financing capital improvements in the nonprofit sector is becoming increasingly difficult. Explored here is an innovative approach that makes private sector capital available to tax-exempt institutions. Cooper Hospital in Camden, New Jersey, and Newcomb Medical Center in Vineland, New Jersey, provide case histories for this approach.

Capital Financing↗
PubMed1985

Multicenter clinical evaluation of a hydrocolloid dressing for leg ulcers.

The need for a moist environment for the normal healing process led to the development of occlusive dressings. Results from this study support the contention that a moist wound environment is favorable to the healing process in humans as well as in animal models. Hydrocolloid dressings are effective in the practical daily management of chronic and even refractive ulcerations of the lower extremities and offer a time-saving treatment alternative with a high degree of patient acceptability.

Adolescent↗
PubMed1985

Glucose tolerance test in Israeli pregnant women.

An oral glucose tolerance test (GTT) was performed in 1,055 healthy Israeli women at various stages of pregnancy. The whole venous blood glucose levels were higher in Israeli pregnant women than in American pregnant women. By adding 2 SD to the mean values, the upper limits of the oral GTT in the Israeli pregnant women were higher than the corresponding limits in American pregnant women. According to our results, 2.7% of Israeli pregnant women have gestational diabetes. However, if American standards are used, then 3.7% of our population would be considered to have gestational diabetes. Each population should be evaluated, therefore, according to its specific standards. The mean +/- 2 SD glucose levels of the GTT in pregnant women at age greater than or equal to 30 years were higher than those of the entire population of pregnant women. It is suggested, therefore, that the GTT of each pregnant woman should be considered according to her age-group.

Adolescent↗
PubMed1984

Effect of 5-azacytidine on deoxyribonucleic acid methylation in Escherichia coli K12.

5-Azacytidine inhibits Escherichia coli DNA(cytosine-5)methylase when added to growing cells. The time-course of recovery of methylase activity and the appearance of 5-methylcytosine in DNA following removal of the drug was studied. When E. coli K12 was treated with 5-azacytidine for 30 min, DNA (cytosine-5)methylase levels decreased to less than 10% of control levels and slowly recovered to control levels after seven generations of growth. 5-Methylcytosine synthesis in DNA remained at less than 10% of control levels for three generations after treatment and returned to control levels after six generations of growth. In contrast, beta-galactosidase levels in induced cells, which declined to 66% of control one generation after treatment, returned to control by the third generation of growth. The rate of induction of beta-galactosidase had returned to the control rate two generations after growth resumed. Since azacytidine-containing DNA inhibits DNA-cytosine methylases in vitro, the prolonged inhibition of cytosine methylation in E. coli K12 following treatment with the drug could be due to the persistence of the drug in DNA and thus inhibition of newly synthesized enzymes.

Azacitidine↗
PubMed1984

Sexual histories, attitudes, and behavior of schizophrenic and "normal" women.

Data on sexual history and current sexual functioning were collected from 20 schizophrenic women and 15 normal volunteers. Schizophrenic women, compared to normal volunteers, reported a higher incidence of sexual abuse premorbidly, particularly during childhood, as well as after the onset of frank psychotic symptomatology. Patients also learned about sexual interaction and began menstruating earlier and had more negative feelings toward menstruating. In addition, psychosexual dysfunctions were markedly more common among the schizophrenic women, both pre- and postmorbidly. Compared to only 13.4% of the normal women, 60% of the schizophrenic women had never experienced orgasm. Patients did not believe that sexual activity worsened their illness, and only 20% of the patients thought their illness had adversely affected their sexual behavior.

Adult↗
PubMed1984

Group B streptococcus amnionitis with intact membranes associated with quintuplet delivery.

Chorioamnionitis is a frequent cause of premature labour and delivery, as well as of maternal and neonatal mortality. Group B streptococcus (GBS) has emerged over the past decade as a common pathogen in the etiology of neonatal sepsis. The case of chorioamnionitis reported here is unusual for three reasons: the premature labour was associated with intact membrane and amniotic fluid infected with GBS; all 5 infants were contaminated with GBS and all infants survived. Chorioamniotitis with intact membranes raises some questions regarding the antepartum use of steroids (potent anti-inflammatory agents), etc. The likelihood of chorioamnionitis in spite of cervical mucus, intact membranes, and the bacteriostatic activity of the amniotic fluid should alert the obstetrician to take special precautions, such as weekly vaginal cultures and appropriate vaginal antimicrobial treatment, in cases of imminent premature delivery.

Adult↗
PubMed1984

Apical closure. Report of two cases.

Two young patients with fractured maxillary incisors were treated. Pulpotomies were performed. In one calcium hydroxide was used as a dressing, and in the other zinc oxide-eugenol paste was used. Postoperative clinical and histologic evaluations revealed similar results in both cases, although the teeth treated with calcium hydroxide exhibited significantly more dentin bridging.

Calcium Hydroxide↗
PubMed1984

A test for the practical evaluation of male fertility by acridine orange (AO) fluorescence.

A new and practical test for evaluating the fertility of a male subject has been developed. Twenty-eight donors whose semen had induced at least one pregnancy resulting in a normal delivery and 61 patients attending our infertility clinic were studied. Semen smears stained with acridine orange were read on a fluorescence microscope; sperm heads appeared either green (fertile) or red ( nonfertile ). We introduce the concept of an "effective sperm count" which is obtained by multiplying the percentage of green-fluorescing sperm by the actual sperm count. Of our fertile subjects, 27 of 28 (96.4%) exhibited an effective sperm count of greater than or equal to 50 million/ml, while 60 of 61 (98.3%) infertile patients fell below this value. The percent green correlates with neither actual sperm count nor motility, indicating that this test measures a new parameter of male fertility.

Acridine Orange↗
PubMed1984

Effects of chloroquine on the feeding mechanism of the intraerythrocytic human malarial parasite Plasmodium falciparum.

Ultrastructural investigations of P. falciparum cultivated in vitro in human erythrocytes revealed new features of the feeding mechanism of the parasite. Mature trophozoites and schizonts take up a portion of the host cytosol by endocytosis which is restricted to cytostomes and which involves the invagination of both parasitophorous and parasite membranes. The resulting endocytic vesicles, surrounded by two concentric membranes, migrate towards the central food vacuole membrane. The external membrane of the endocytic vesicles apposes that of the food vacuole, leading to the internalization of vesicles bounded by a single membrane into the vacuole space where they are rapidly degraded. We conclude from this sequence of events that endocytic vesicles fuse with the food vacuole. Treatment of infected cells with therapeutic concentrations of chloroquine inhibited the last step of the feeding process, i.e. vacuolar degradation. This was manifested by the accumulation within the vacuolar space of intact vesicles bounded by single membranes. The implications of these findings for the antimalarial activity of chloroquine are discussed.

Animals↗
PubMed1984

Effects of mitochondrial protein synthesis inhibitors on the incorporation of isoleucine into Plasmodium falciparum in vitro.

Plasmodium falciparum was grown in human erythrocytes in vitro and the effect of chloramphenicol, erythromycin, and tetracycline on growth and maturation of the parasites and on their ability to incorporate [3H]isoleucine into protein was observed. Exposure of rings to high concentrations of chloramphenicol had little effect on subsequent maturation of the rings whereas brief (4 h) exposure of trophozoites caused a dose-dependent inhibition of subsequent ring formation. Incorporation of [3H]isoleucine into protein was not affected during at least 6 h of exposure to high concentration of the three drugs examined, but appreciable inhibition was observed after 21 h, with chloramphenicol being the least effective inhibitor. These results suggest that there is a stage-specific effect of inhibition of mitochondrial protein synthesis on subsequent development and that the mitochondria are essential for growth and development even though they lack a functional Krebs cycle.

Animals↗