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Biomedical subjects

S Freeman

Publications and source records attributed to S Freeman.

At least 217 records · Page 12Linked to original sources
PubMed1979

Preliminary histologic evaluation of a biocompatible mesh for tracheal reconstruction.

The purpose of this study was to evaluate a porous Dacron - urethane mesh tracheal prosthesis in large dogs with surgically created discontinuous defects of the cervical trachea. Some protheses were carbon coated in an attempt to improve biocompatibility. Histology was performed on 2 dogs. The mucosa regenerated entirely covering the prosthesis. Respiratory epithelium was formed over a large central portion of the tracheas.

Animals↗
PubMed1978

A spectral study of human ceruloplasmin.

The absorption, luminescence and CD spectra of human ceruloplasmin were studied. The absorption spectrum in the infrared, and the CD spectrum in the ultraviolet, both indicate the presence of beta conformation in the native structure of the protein. From the magnitude of the measured ellipticity, it is estimated that 0.46 of the amino acid residues are in the beta conformation, the remaining 0.54 being in unordered form. A comparison of the fluorescence and phosphorescence properties of native and apoceruloplasmin shows that the presence of copper causes the quenching of tryptophanyl luminescence, probably through energy transfer to the copper chromophores. By the combined resolution of the absorption and CD spectra, it was concluded that the copper chromophores are involved in six electronic transitions in the region 300--900 nm. Our results provide evidence for an interaction between the copper chromophores responsible for the 330 nm absorption in ceruloplasmin.

Apoproteins↗
PubMed1978

Neurocranial reconstruction using an elastomer-coated cloth mesh and bone grafting.

The purpose of this report is to present out 5-year experience in reconstructing large bony defects in the cranial vault of 16 patients. The method employs an alloplastic implant device made of elastomer-coated cloth mesh, used in conjunction with bone grafting [D. L. Leake and M. Habal, J. Biomed. Mater. Res., 10, 555 (1976)]. The cranial defects ranged in size from 6 X 6 cm to 15 X 17 cm. The defects were in the frontal, temporoparietal, and occipital regions. Particularly challenging was the frontal-orbital region involving the superciliary ridges. The alloplastic implant provides controlled contour of the bone graft material while providing strength and stability during healing. The implant has adequate but not complete ridigity, allowing adaptability inthe operating room. The elastomer used is a polyetherurethane. Any biocompatible cloth mesh can be used, but Dacron [poly(ethylene terephthalate)] was chosen because of its extensive implant history. Contrasted with reconstruction using only bone, where as many as half of the cases had uneveness and were found to be anesthetically unsatisfactory, the technique described here has resulted in aesthetically excellent results and an intact neurocranium in the 16 patients studied thus far.

Adolescent↗