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Biomedical subjects

S Fong

Publications and source records attributed to S Fong.

134 records · Page 8Linked to original sources
PubMed1977

Immunity to lymphoid tumors in syngeneic mice by immunization with mitomycin C-treated cells.

Immunization of mice with syngeneic mitomycin C-treated lymphoid tumor cells (EL-4 and S49A) conferred a high degree of immunity to transplantation with viable tumor cells in syngeneic animals. The development of this immunity was paralleled by the development of specific cell-mediated cytotoxicity; no anti-tumor antibodies could be detected in the immunized animals. In contrast to the high immunoprophylactic capacity of mitomycin C-treated cells, attempts to utilize these cells for immunotherapy were unsuccessful. Preliminary experiments did not reveal antigenic differences between mitomycin C-treated and untreated tumor cells.

Animals↗
PubMedDate not supplied

Enriched housing masks deficits in place navigation induced by neonatal monosodium glutamate.

Monosodium-L-glutamate (MSG)-induced behavioural deficits were examined under two housing conditions. Male Wistar rat pups were cross-fostered at birth and injected with MSG on days 2 to 11 postpartum. Control pups were injected with saline (Sal) of equivalent volume. Following weaning at day 25 the rats were allocated to either "enriched" (EC) or "impoverished" (IC) housing, thus forming four treatment groups: MSG-EC, MSG-IC, Sal-EC, and Sal-IC. Thirty-five days later all rats were tested in the open field and in the place navigation task. Multivariate analysis of variance (MANOVA) revealed a significant two-way interaction of the housing x drug variables. While the MSG-IC rats were deficient in the water maze, the performance of the MSG-EC approached that of saline-injected controls. Although the Sal-IC rats developed higher body weights than the Sal-EC rats the MSG-EC and MSG-IC rats did not differ in body weight. The housing by drug treatment interaction was not apparent in the open field.

Adrenal Glands↗
PubMedDate not supplied

A systematic review of the effectiveness of environmental awareness interventions.

PURPOSE: To evaluate and summarize evidence on the effectiveness of interventions available to public health staff regarding the protection of the public from environmental risks. METHOD: This systematic review involved a comprehensive literature search, screening for relevance, quality assessment of relevant studies, data extraction and synthesis. RESULTS: Fourteen of 65 relevant studies were of 'moderate' or 'strong' quality. Intervention types in these 14 studies included: mass campaign, counselling, school curriculum, educational sessions, and distribution of printed materials. Short-term improvements in awareness or knowledge were observed in 13 of the 14 studies. Eight of 13 studies that examined behavioural outcomes observed short-term improvements in self-reported behavioural outcomes. CONCLUSIONS: Positive short-term changes in health-protective awareness, knowledge and self-reported behaviour appear to be associated with relatively intensive interventions that use multiple methods and settings, and/or are delivered over multiple sessions.

Awareness↗
PubMedDate not supplied

Autoantibody production in Sjögren's syndrome: a hypothesis regarding defects in somatic diversification of germ line encoded genes.

Patients with primary Sjögren's syndrome (SS) have rheumatoid factor (anti-IgG Fc antibody, RF) in their sera that contains a crossreactive idiotype (CRI) defined by monoclonal antibody 17-109. This CRI is shared by SS patients and certain patients with Waldenstrom's macroglobulinemia. This CRI was not found in increased frequency in RF from rheumatoid arthritis patients lacking SS. The structural basis for this CRI is the highly conserved kappa chain of the Vk IIIb sub-subgroup. In SS patients, the CRI is present on both IgA RF and IgM RF, accounting for 5-20% of the total RF. Recent studies have shown that a germ line encoded kappa variable region gene (Humkv 325, cloned from a placental DNA library) has DNA sequence that encodes the variable region amino acid sequences of CRI positive kappa chains. Using MoAb 17-109, we have been able to determine the tissue distribution of CRI+ B-cells. We found an increased frequency in the salivary gland biopsies of SS patients and also in their intestinal mucosal tissues (i.e. Peyer's patch). In comparison, we also detected an increased frequency of CRI+ B-cells in the Peyer's patch regions of normals. Taken together, these results suggest that CRI+ B-cells may play an important role in normal mucosal immunity and these CRI+ B-cells have migrated to the salivary gland in SS patients as part of the inflammatory process directed at autoantigens or exogenous antigen(s) located at a mucosal surface.(ABSTRACT TRUNCATED AT 400 WORDS)

Amino Acid Sequence↗