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Biomedical subjects

S Fine

Publications and source records attributed to S Fine.

At least 91 records · Page 5Linked to original sources
PubMed1982

Recombinant leukocyte A interferon: pharmacokinetics, single-dose tolerance, and biologic effects in cancer patients.

Sixteen patients with advanced cancer were treated with recombinant-DNA-produced pure leukocyte A interferon (IFLrA) intramuscularly in doses ranging from 3 to 198 X 10(6) units. with interval periods of 72 to 96 hours between doses. At the two lowest doses of 3 and 9 million units, there was a cross-over evaluation between IFLrA and partially pure leukocyte interferon (IFN-C) produced from human cells. THe maximum observed serum concentration of IFLrA measured by enzyme immunoassay and bioassay increased with increasing doses. The mean serum concentrations of IFLrA and IFN-C were similar. Clinical effects produced by IFLrA and IFN-C were similar, including fever, chills, myalgias, headache fatigue, and reversible leukopenia and granulocytopenia. Eight patients had transient and mild numbness of the hands or feet, or both. Three patients developed low titers of antibody to IFLrA, Seven of 16 patients showed objective evidence of tumor regression during the study.

Adult↗
PubMed1982

Combined radical radiation therapy and chemotherapy for primary squamous cell carcinoma of the anal canal.

Radical radiation therapy (5000 rads in 20 fractions in 4 weeks) combined with iv mitomycin (10 mg/m2) and 5-FU (1000 mg/m2/24 hours for 4 days) was used to treat 13 patients with locally advanced but operable squamous cell carcinoma of the anal canal. All patients achieved local control and retained anal continence, and none developed metastases. The patients were followed from 4 to 34 months (median, 12). Severe acute gastrointestinal toxic effects were seen in three patients; the same patients had significant thrombocytopenia or leukopenia. Treatment with this combined program may allow conservative management of squamous cell carcinoma of the anal canal and should be considered as an alternative to abdominoperineal resection.

Adult↗
PubMed1979

Juvenile firesetters: do the agencies help?

In an attempt to find out what was being done for juvenile firesetters in their metropolitan community the authors reviewed the records of the local fire marshal, juvenile court, and psychiatric clinic. They found that the various agencies involved with 69 juveniles over a 3-year period were unable to coordinate their efforts and were largely unsuccessful in controlling the firesetting. Because the families of firesetters seem to have many other social problems, the authors recommend early inpatient assessment and possible referral to foster homes or residential treatment settings for juvenile firesetters.

Adolescent↗
PubMed1978

Floorplans and cartoon strips--diagnostic techniques in working with children.

Two useful techniques in assessing and treating children ages 7-15 are described. Children are asked to draw a floorplan of their home. Drawing the floorplan reveals the child's ability to approach a task; some of the preferred activities in the home; the sleeping arrangements; and, most importantly, other significant people. With some children, constructing a comic strip can reveal their core conflicts and establish rapport. The comic strip is particularly useful with children who are very inhibited in their verbal utterances.

Adolescent↗
PubMed1977

Pretreatment of cadaver donors with methylprednisolone in human renal allografts.

Fifty cadaveric kidney donors were randomly allocated to two groups. Group 1 received 5 grams of intravenously administered methylprednisolone two to four hours prior to organ harvesting after the pronouncement of brain death. Group 2, which served as the control group, received no pretreatment. Of 100 kidneys harvested, 16 were discarded for various reasons, and 84 were transplanted and were available for evaluation, 40 from the pretreatment group and 44 from the control group. The transplant centers using these kidneys were unaware of the status of the kidney they received, that is, whether it was from a pretreated or a control group. The two groups of kidneys, pretreated and control, did not differ according to the length of warm or cold ischemia time or presence of preformed cytotoxic antibodies. The difference in graft failure between the two groups at three months was insignificant, even when the two groups were compared according to the method of preservation used.

Antibody Formation↗
PubMed1977

Selected volunteer adolescents in adolescent group therapy.

Twenty-one adolescents had therapy in a group containing three volunteer adolescents over a period of ten months. Fifteen adolescents came to five sessions or more. A description of the group shows how many of the group members model their behavior and attitudes on those of the volunteers. It is suggested that using volunteers is a useful method of initiating and maintaining a group of adolescents.

Adjustment Disorders↗
PubMed1976

Volunteer adolescents in adolescent group therapy. Effects on patients and volunteers.

The effects on patients, volunteers and staff of using volunteer adolescents in adolescent group therapy are examined. From 40 candidates eight volunteers were selected and oriented to the group process. Four volunteers and four patients were placed in each of two groups, and eight patients were placed in the third group. Patients and volunteers were aware of their identities in the first group session. Attendance in the groups with volunteers was better than in the group without. The volunteers themselves gained new knowledge and skills, and their presence was even helpful to the group leaders.

Adolescent↗
PubMed1975

A follow-up of blind diabetic patients.

This report concerns the subsequent fate of 95 blind diabetics who were using a Seeing Eye guide dog in 1964. In 1973, 9 years later, 40 were known to be dead, 31 were known to be alive, and no data were available on 24. The average interval from onset of severe blindness to death in 37 of the 40 who had died is 9.4 years. The mean age at death was 43.2 years for the group. This compares favorably to our original study which showed an average survival from onset to blindness to death of 5.8 years, and an average age at death of 35.9 years. Because follow-up data are incomplete for the 1964-1973 interval, the true figures may be poorer than the ones reported now. In any case, it is apparent that the life expectancy of the blind diabetic is still poor after the onset of blindness from severe retinopathy.

Adult↗