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Biomedical subjects

S Ferrer

Publications and source records attributed to S Ferrer.

At least 73 records · Page 4Linked to original sources
PubMed1989

Transformation of the dermatophyte Trichophyton mentagrophytes to hygromycin B resistance.

A transformation system for the ringworm-producing dermatophyte Trichophyton mentagrophytes has been developed. The system employs the plasmid pHIS, which contains a bacterial hygromycin B phosphotransferase gene linked to Cochliobolus heterostrophus regulatory sequences (B. G. Turgeon, R. C. Garber, and O. C. Yoder, Mol. Cell. Biol. 7:3297-3305, 1987). This plasmid confers hygromycin B resistance to T. mentagrophytes. The DNA was stably integrated into the fungal genome, and the number and sites of integrations varied among transformants. Transformant clones were capable of infecting guinea pigs. This system opens the way for the molecular genetic analysis of the interaction of T. mentagrophytes with epithelial animal tissues.

Animals↗
PubMed1985

[Myalgias].

Explore the source record for details and available documents.

AMP Deaminase↗
PubMed1983

[Determination of plasma prolactin in patients with breast dysplasia].

Prolactin is determined by means of radioimmunoassay in the postovulatory phase of a group of women with mammary dysplasia. A specially increased concentration of prolactin is found in the proliferative dysplasias (multiple intraductal papillomatosis and invasive sclerosing adenosis), that may be considered as preneoplastic processes.

Breast Neoplasms↗
PubMed1982

[Syndromic diversities in Creutzfeldt-Jakob disease: neurophysiological and histopathological correlates].

Two syndromatic forms of Creutzfeldt-Jakob disease are illustrated with data from two cases confirmed by necropsy and studied by means of electroencephalogram, evoked potential recording and neuropathological techniques. One of the cases presented the typical hypersynchronous periodic discharges through to be characteristic of this disease. The other did not exhibit epileptiform discharges, showing an evolution in which progressive diffuse slowing was the prominent feature. Cortical spongyosis, gliosis, and neuronal lose were intense in the case showing spikes, and moderate in the one without spikes. Subcortical involvement was similar in both cases. This different topography of pathological involvement might explain, in addition to electroencephalographic findings, the different behavior of somatosensory evoked potentials, which were of larger amplitude in the case showing epileptiform discharges, although in both cases deterioration of clinical state was accompanied by a progressive amplitude decrement in the evoked potential. Sleep induced by barbiturates was disrupted in the case with spikes, its pattern being closer to normal in the case with less severe cortical involvement. A Wada test demonstrated that discharges in the hemispheres were independent. Spike periodicity is discussed. It is postulated that the heavier involvement of cortical layers II to IV deprive the remaining pyramidal cells of inhibitory influences, a condition which might explain the generation of periodic spike discharges.

Adult↗
PubMed1980

Subacute spongiform encephalopathy (Creutzfeldt-Jakob disease) associated with normal-pressure hydrocephalus Anatomoclinical report of one case.

The occurrence of two different dementing diseases, Creutzfeldt-Jakob disease and normal-pressure hydrocephalus in a single patient is described. The inefficacy of a shunt procedure in this particular case, and the need of a brain biopsy in patients with normal-pressure hydrocephalus before undergoing cerebrospinal fluid shunting are stressed. A purely coincidental occurrence, or a possible aetiopathogenic relationship between both diseases are postulated.

Adult↗
PubMed1978

Three new species of penicillium.

Three new species of microfungi belonging to the genus Penicillium Link ex Fries are described and illustrated. All but one have been isolated from the atmosphere of las Palmas, capital city of the island of Gran Canaria (Canary Islands, Spain). They clearly differ from all species of the genus described so far and are, therefore, described and proposed as new species: Penicillium hispanicum sp. nov., Penicillium grancanariae sp. nov., and Penicillium palmensis sp. nov.

Air Microbiology↗