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S Fankhauser

Publications and source records attributed to S Fankhauser.

At least 37 records · Page 2Linked to original sources
PubMed1976

[Purity and antigenicity of the new insulin preparations].

A short review on new types of insulin preparations purified by chromatography is presented. The purity of these new chromatographed insulins, which have almost completely replaced the conventional types of insulin, has been considerably improved. Our own investigations have revealed significantly lower antigenicity of porcine depot preparations compared with beef or mixed beef-pork insulins. By means of gel filtration and additional anion exchange chromatography the antigenicity of porcine insulin can be significantly reduced. Monocomponent insulins prepared by these methods produce low titers of insulin antibodies in only one third of diabetics treated by insulin for the first time. Mixed beef-pork Lente Insulin purified by single chromatography is also less antigenic than Lente Insulin of conventional purity, but more antigenic than pork insulin (e.g. Monotard). Pork insulin purified by chromatography is indicated in cases of insulin allergy, insulin resistance and lipoatrophy, and also for first insulin treatment in younger and middle-aged diabetics.

Animals↗
PubMed1975

[The diagnosis of hyperparathyroidism and hypoparathyroidism].

Some recent pathophysiologic, diagnostic and therapeutic aspects of hyper- and hypoparathyroidism are reviewed. Three clinical forms of hyperparathyroidism can be distinguished: one with symptoms essentially affecting the skeleton, a second with renal symptoms and a third with scant and sometimes atypical symptoms. The most reliable laboratory criteria for diagnosis of hyperparathyroidism are serum levels of calcium and immunoreactive parathormone. Some authors believe that with a combination of these two parameters a diagnosis is possible in almost all cases. Other determinations such as serum phosphorus and 24-h urinary calcium, and most special tests, are less reliable. A new method for preoperative localization of adenoma, involving catheterization of the thyroid veins, should make future operative procedures easier. With regard to pseudohypoparathyroidism, recent work has contributed to a greater understanding of the pathophysiologic mechanism. On the basis of normal or elevated parathormone in these cases and in other investigations, Albright's hypothesis, which assumes resistance of the renal tubules to parathormone is considered to be proven. Hypoparathyroidism is usually fairly easy to treat with vitamin D or AT 10 and calcium supplements, provided that frequent and careful checks on serum calcium levels are made.

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