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Biomedical subjects

S F Gao

Publications and source records attributed to S F Gao.

8 recordsLinked to original sources

[Resections of tracheal or bronchial tumors and tracheal or bronchoplasty: experience with 53 patients].

UNLABELLED: From January 1982 to December 1992, a total of 485 patients with pulmonary tumors were treated by surgical procedure, in which 53 cases (92.4%) were treated by segmental resections of trachea, carina, bronchi and with tracheal-or bronchoplasty. In this series of tracheal-or bronchial tumors, four (7.6%) were benign, 49 (92.4%) were malignant. Segmental resections of trachea and carina with plastic procedures were performed on 6 cases, sleeve resections of main bronchi with plastic procedures were performed on 47 cases. One case (1.9%) died of respiratory failure postoperatively. FOLLOW-UP: the survival rate of 5 years was 35% (6/17), three years' was 56% (18/32), one year's was 77.8 (35/45). We considered that the patients with tumors of trachea or bronchi had significant symptom-irritated cough with bloody sputum. Earlier diagnosis, earlier surgical treatment could get a better therapeutic result. Segmental resections of trachea and sleeve resections of bronchi with lobectomy extended the indications for treating pulmonary neoplasm, and saved the normal lung tissues and functions as more as possible, provided some operative chances for elder patients and those cases with insufficient pulmonary functions. This procedure improved the patients's life quality and left the possibility of reoperation.

Adult

[Tumor necrosis factor gene expression in ovarian tumor].

The tumor necrosis factor (TNF) gene expression in ovarian tumor was observed with digoxigenin labeled TNF-alpha cDNA probes and in situ hybridization technique. 54 cases of fresh biopsies of the ovarian tumor and 10 cases of normal ovaries were snap frozen sectioned. The results showed that the average positive rate of TNF gene expression in some ovarian cells and tumor infiltrating lymphocytes (TIL) was higher than that in the borderline and benign tumor cells and TIL. The more advanced clinical stages, the higher does positive rate of TNF gene expression in the cancer cell and the smaller dose in the TIL. It was appeared that TNF gene expression of the tumor cells and TIL was connected with clinical stage and tissue typing of ovarian tumor. The data suggested TNF gene expression of cancer cell might play a role in the progress of ovarian cancer and as a marker of the advanced malignancy tumors. In addition, TNF gene expression of the TIL might mark the restinced state of the host immunology.

Adult