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Biomedical subjects

S F Bean

Publications and source records attributed to S F Bean.

At least 19 recordsLinked to original sources
PubMed1988

Systemic lupus erythematosus presenting as a bullous eruption in a child.

An 8-year-old girl presented with a generalized bullous eruption clinically resembling bullous pemphigoid or chronic bullous disease of childhood. Further study revealed immunopathologic findings seen in patients with epidermolysis bullosa acquisita or bullous systemic lupus erythematosus (SLE). Although she did not fulfill the American Rheumatism Association (Atlanta) criteria for SLE at her presentation, one year later she went on to do so. As well as being the youngest patient reported with bullous SLE, our patient is noteworthy because the bullous eruption was the initial manifestation of her SLE. Bullous SLE should be considered in the differential diagnosis of children presenting with generalized bullous eruptions.

Age Factors↗
PubMed1987

Diagnosis and management of chronic oral mucosal bullous diseases.

Chronic blistering diseases involving the mouth are frequently difficult to diagnose correctly and can present a problem with management. Pemphigus vulgaris, cicatricial pemphigoid, and recurrent oral erythema multiforme may be difficult to separate from each other and from other erosive diseases such as recurrent aphthous stomatitis and erosive lichen planus. Essential to establishing a correct diagnosis is a pertinent history, a physical examination, and histopathologic and direct immunofluorescence studies. Oral pemphigus vulgaris can usually be managed successfully with prednisone alone but occasionally another immunosuppressive medication in concurrence with prednisone is necessary. Dapsone is the most efficacious treatment for oral cicatricial pemphigoid, and brief courses of prednisone usually control individual episodes of severe recurrent oral erythema multiforme. It is important that physicians who undertake treatment of these diseases be fully aware of the untoward effects of the medications that are being utilized.

Chronic Disease↗
PubMed1986

Oral acyclovir for the prevention of herpes-associated erythema multiforme.

Herpes simplex virus is the single most common precipitator of erythema multiforme. Typically, erythema multiforme lesions appear 10 to 14 days after a recurrent herpes simplex virus infection and attacks can be disabling when they occur at frequent intervals. Prior to the introduction of acyclovir (Zovirax), there was no effective therapy to prevent herpes-associated erythema multiforme. Four patients were treated with a maintenance dose of acyclovir for periods ranging from 10 to 26 months; there were no significant side effects from the drug and only one recurrence of erythema multiforme. Oral acyclovir may become the treatment of choice for herpes-associated erythema multiforme.

Acyclovir↗
PubMed1986

Localized cicatricial pemphigoid (Brunsting-Perry syndrome).

A patient who presented with scarring alopecia from a vesicular disorder was diagnosed as having localized cicatricial pemphigoid. The diagnosis was confirmed by histopathology and immunofluorescent studies. The clinical, immunologic, and therapeutic features of this entity are reviewed.

Adult↗
PubMed1984

Bullous dermatoses.

Explore the source record for details and available documents.

Bibliographies as Topic↗
PubMed1983

Recurrent oral erythema multiforme. Clinical experience with 11 patients.

Recurrent oral erythema multiforme is a distinct, but less-well-recognized variant of the erythema multiforme group of diseases. It is characterized by recurrent blistering of the mouth, periodic recurrences, prolonged duration, and considerable morbidity. The cause is unknown; however, a number of precipitating factors have been suggested. Patients with severe involvement usually require orally administered corticosteroids for adequate control.

Adolescent↗
PubMed1980

Brunsting-Perry cicatricial pemphigoid associated with bullous pemphigoid.

Brunsting-Perry cicatricial pemphigoid is a chronic recurrent vesiculobullous eruption that occurs predominantly on the head and neck. Because of the clinical, histologic, and immunologic similarity to cicatricial pemphigoid, it has been suggested that Brunsting-Perry cicatricial pemphigoid represents the cutaneous counterpart of cicatricial pemphigoid and should be included as a member of the pemphigoid spectrum of diseases. The concurrence of Brunsting-Perry cicatricial pemphigoid and bullous pemphigoid, as seen in the patient in this report, supports this viewpoint.

Adult↗
PubMed1980

Hodgkin's disease with specific bullous lesions.

A variety of bullous eruptions have been reported in patients with Hodgkin's disease, among them erythema multiforme, herpesvirus infections, bullous impetigo, prurigo-like papules with vesicles, drug eruptions, bullous pemphigoid, dermatitis herpetiformis, and acquired epidermolysis bullosa. We now describe a patient whose bullous eruption was thought initially to be bullous pemphigoid. However, histopathologic examination of a bulla showed a lymphomatous infiltrate beneath an intraepidermal and subepidermal blister. These pathological findings seem to be unique and we interpret them to be those of bullous Hodgkin's disease.

Diagnosis, Differential↗
PubMed1977

Immunopathology of cicatricial pemphigoid: studies of complement deposition.

Immunopathologic investigations were conducted on the sera and oral mucosal tissue specimens of 23 patients with cicatricial pemphigoid. A linear, continuous basement membrane zone pattern was noted in 83% of oral mucosal biopsy specimens studied. This pattern is indistinguishable from the pattern noted in immunofluorescence studies of bullous pemphigoid, herpes gestationis, and some cases of desquamative gingivitis. Complement studies provided data supportive of classical pathway activation in cicatricial pemphigoid tissue. Deposition of IgA with Factor B, properdin, and C3 raised the possibility of alternative pathway activation, a question requiring further study. Circulating antibasement membrane zone antibodies were noted in the sera of two patients with cicatricial pemphigoid.

Basement Membrane↗
PubMed1977

Pemphigus vegetans of Hallopeau: immunofluorescent studies.

Immunofluorescent techniques were used in the study of tissue from a patient with pemphigus vegetans of Hallopeau. The findings were typical of pemphigus, confirming the propriety of classifying this entity as a benign variant of pemphigus, rather than a disease of purely microbial etiology. The question is raised whether other types of vegetating pyodermas actually are separate diseases or represent a spectrum of pemphigus with the clinical appearance dependent on the patient's immunity to his disease. Immunofluorescent studies are proposed as a basis for classification.

Aged↗
PubMed1977

Cicatricial pemphigoid of Brunsting-Perry. Immunofluorescent studies.

Six patients with a vesiculobullous eruption of the type described by Brunsting and Perry as benign pemphigoid were studied by direct and indirect immunofluorescence. All six showed linear deposits of IgG but not IgM or IgA at the epidermal-dermal junction. One case also showed C3 deposition and one patient had circulating antibasement membrane zone antibodies in a titer of 1280. These data provide strong evidence that this condition belongs to the cicatricial pemphigoid-bullous pemphigoid spectrum of disease.

Aged↗
PubMed1976

Proper biopsy technique for immunofluorescence tests on skin.

Successful use of direct immunofluorescence tests on skin depends on selection of the appropriate biopsy site, careful preparation of the specimen, and prompt transportation to a reliable laboratory. Recommendations for selection of biopsy sites in various dermatoses and methods available for handling specimens are discussed.

Biopsy↗
PubMed1976

Vesicular pemphigoid.

Seven patients had a chronic eruption of small vesicles that was initially considered to be atypical dermatitis herpetiformis. Histopathologic studies disclosed a subepidermal bulla that was compatible with either bullous pemphigoid or dermatitis herpetiformis. Immunofluorescence studies demonstrated deposition of IgG or C3, Or both, at the basement-membrane zone (BMZ) in six of seven patients. In four patients, circulating BMZ antibodies were detected also. We belive that these cases represent a vesicular form of bullous pemphigoid.

Adult↗
PubMed1975

Immunofluorescent studies of ocular cicatricial pemphigoid.

Using direct and indirect immunofluorescent techniques, we studied ten patients with cicatricial pemphigoid (chronic cicatricial conjunctivitis). Serologic and histologic evaluation of 13 conjunctival, 12 mucous membrane, and 11 skin specimens from the ten patients showed that three had immunoglobulin deposition at the basement membrane zone of the conjunctiva. One patient had immunoglobulin deposited in the affected skin and oral mucosa. Two patients had circulating basement membrane zone antibodies that bound to their own tissue but not to guinea pig lip or human skin.

Adult↗
PubMed1975

Pemphigus involving the eyes.

Two persons with pemphigus vulgaris involving the eyes were studied. In one case, in vivo-fixed intercellular deposition of IgG was demonstrated in a specimen from the conjunctiva.

Aged↗