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Biomedical subjects

S Eykyn

Publications and source records attributed to S Eykyn.

At least 37 records · Page 2Linked to original sources
PubMed1980

Staphylococcal bacteraemia, fusidic acid, and jaundice.

Fusidic acid was used to treat 131 out of 250 patients with staphylococcal bacteraemia over 10 years. Other antimicrobial agents were given to the 119 remaining patients. Thirty-seven patients were already jaundiced before antibiotic treatment was started. Jaundice developed during treatment in 38 out of 112 patients given fusidic acid (34%) and in two out of 101 patients given other antimicrobials. The incidence of jaundice was higher in patients given fusidic acid intravenously (48%) rather than by mouth (13%). Jaundice appeared within 48 hours after the administration of fusidic acid in 93% of these cases. When the drug was stopped serum bilirubin concentrations fell to normal values within four days in those patients in whom they had been previously normal and who survived the bacteraemic episode. Fusidic acid was associated with increasing jaundice in 13 of 19 patients (68%) already jaundiced before it was given. In six out of 32 patients who developed jaundice while receiving intravenous fusidic acid serum alkaline phosphatase activity was raised suggestive of cholestatic jaundice. The mechanism in the remaining patients was unknown. Fusidic acid, particularly the intravenous preparation, in invaluable in treating severe staphylococcal infection but should be used with caution in patients with abnormal liver function. Patients receiving intravenous fusidic acid should be given the oral form of the drug as soon as their clinical condition permits.

Adolescent↗
PubMed1980

The rapid laboratory diagnosis of anaerobic infection.

In order to assess the rapid laboratory diagnosis of anaerobic pyogenic infection, we compared the results of Gram stains, ultra-violet fluorescence and gas chromatography, all performed directly on pus, with those of anaerobic culture. Fluorescence was most rapid but there were many negatives unless Bacteroides melaninogenicus was present. Gas chromatography was rapid and sensitive but there were some false negatives, often in pure Bacteroides fragilis infection, and a few false positives. Gram-staining was also rapid, but only helpful on its own when there were large numbers of organisms of mixed or characteristic morphology. The three methods together almost always provided a reliable and rapid presumptive diagnosis of anaerobic pyogenic infection.

Anaerobiosis↗
PubMed1976

Co-trimoxazole in prevention of bacteriuria after prostatectomy.

In a prospective, double-blind trial prophylactic cotrimoxazole produced a highly significant reduction in the incidence of bacteriuria after prostatectomy. Only two out of 38 patients who received the drug developed bacteriuria compared with 19 out of 36 patients on placebo. Klebsiella-Enterobacter spp and coagulase-negative staphylococci were responsible for most infections. Although co-trimoxazole prophylaxis is obviously effective, widespread use might increase the incidence of bacterial resistance.

Aged↗
PubMed1976

Antibacterial activity of cefuroxime, a new cephalosporin antibiotic, compared with that of cephaloridine, cephalothin, and cefamandole.

The in vitro activity of cefuroxime, a new cephalosporin derivative, was compared with that of cephaloridine, cephalothin, and cefamandole against strains of gram-positive and gram-negative bacteria recently isolated from clinical sources. Cefuroxime showed very similar activity to cefamandole against Staphylococcus aureus, Haemophilus influenzae, and most members of the Enterobacteriaceae. It was more active than cefamandole against gonococci, pneumococci, and most streptococci. Increasing the inoculum size appeared to have less effect on the minimum inhibitory concentrations of cefuroxime for gram-negative bacilli than has been found with the other cephalosporin derivatives, and minimum bactericidal concentrations of cefuroxime were only marginally greater than minimum inhibitory concentrations.

Bacteria↗
PubMed1975

Staphylococcus aureus transmitted in transplanted kidneys.

Staphylococcus aureus septicaemia developed shortly after transplantation in both recipients of transplanted kidneys from a donor who had received electrical burns. In each case the organism appeared initially in the urine. All staphylococci isolated were phage type 6/47/54/75. Transplant nephrectomy was necessary in both recipients because of complications of infection, and one recipient died. These results draw attention to the possible significance of Staph. aureus in the urine of recipients after transplantation and to the potential risk of transplanting kidneys from a burned donor.

Adult↗
PubMed1975

Urinary tract infection following trans-rectal biopsy of the prostate.

An unacceptably high incidence of urinary tract infection was found in a retrospective survey of patients undergoing trans-rectal biopsy of the prostate. The incidence was considerably greater than that found in a prospective survey of bladder endoscopy alone. It is suggested that preoperative antibiotic prophylaxis might be worthwhile in this situation.

Anti-Bacterial Agents↗