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Biomedical subjects

S Eto

Publications and source records attributed to S Eto.

At least 217 records · Page 12Linked to original sources
PubMed1985

[Clinical significance of serum sialic acid in rheumatoid arthritis and systemic lupus erythematosus].

A study of the clinical significance of serum sialic acid (SA) in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is presented in this paper. Because a definite correlation (n = 30, r = 0.74, P less than 0.001) between SA and erythrocyte sedimentation rate (ESR) and a good reflection of SA to disease activity in clinical course were revealed in RA patients, we were able to use SA in place of ESR as a marker of disease activity and a guide to treatment. On the other hand, although a good correlation (n = 22, r = 0.62, P less than 0.01) between SA and ESR was revealed in SLE patients, SA was inapplicable as a marker of disease activity in SLE because of a poor correlation between SA and anti-DNA antibody or serum complement which is mainly used as a marker of disease activity and a guide to treatment.

Antibodies, Antinuclear↗
PubMed1985

The presence of macromolecular prolactin in serum of pregnant women and patients with pituitary adenoma.

The heterogeneity of immunoreactive Prolactin (IR-PRL) in serum of pregnant women and patients with pituitary adenoma were studied by Sephadex G-100 gel chromatography. The major IR-PRL peaks in serum of pregnant women were eluted at the position corresponding to that of 125I-PRL and the small amount of IR-PRL peaks were eluted near the void volume (peak 1) and between the void volume and 125I-PRL (peak 2). On the other hand, the proportion of peak 1 and peak 2 to total immunoreactivity was significantly increased in serum of patients with pituitary adenoma compared to those in serum of pregnant women. The rechromatographic studies under conditions of protein denaturation and sulfide cleavage on Sepharose CL-6B column revealed that the peak 1 of the pregnant women and patients with pituitary adenoma were eluted at the position between 125I-AFP and ovalbumine and the molecular weight was estimated to be about 54,000. This macromolecular PRL was also bound specifically to Sepharose coupled with anti-PRL, indicating that this macromolecule contained a sequence of PRL in its structure.

Adenoma↗
PubMed1985

Determination of blood concentration of valproic acid--a comparative study of methods.

The substrate labeled fluorescent immunoassay technique (SLFIA method) was examined in terms of clinical utility for the determination of blood levels of valproic acid (VPA) by comparing it to the enzyme-multiplied immunoassay technique (EMIT method). Both accuracy and precision were very high, and the correlation between the two was excellent (r = 0.985). Practically, the presence of hemoglobin in the sample had little influence on the accuracy. Results show that the SLFIA method is a useful means for the determination of blood concentration of VPA in epileptic patients.

Anticonvulsants↗
PubMed1985

Primary malignant lymphoma of the thyroid in a patient with long-standing Graves' disease.

We have recently encountered a patient with rapidly enlarging thyroid masses histologically diagnosed as diffuse histiocytic lymphoma which developed in the active course of Graves' disease. The primary thyroid lymphoma has been in complete remission after local radiation therapy. The association of Hashimoto's thyroiditis and thyroid lymphoma has well been recognized. Meanwhile, data have accumulated to demonstrate that Hashimoto's thyroiditis and Graves' disease share possible similar causal immunological abnormalities and are closely related entities. However, the association of Graves' disease and primary thyroid lymphoma has never been reported, as far as we know. Therefore, this case may be the first one that supports the natural concept that thyroid lymphoma develops from pre-existing Graves' disease secondary to the similar immunological abnormalities in Hashimoto's thyroiditis.

Aged↗
PubMed1985

Evidence of bone resorption-stimulating factor in adult T-cell leukemia.

Adult T-cell leukemia (ATL) is known to be frequently accompanied by hypercalcemia, but the mechanisms responsible for hypercalcemia in this disorder are not fully understood. We have recently experienced two male patients (25 and 36 yr old) with ATL diagnosed from typical leukemic cells with grooved and folded nucleus, surface marker, anti-ATLA antibody etc. Serum calcium levels of these patients were 16.4 and 21.4 mg/dl, respectively, with no radiological evidence of bone destruction. Peripheral blood leukemic lymphocytes from these patients were purified by the Ficoll-Hypaque method and cultured at a concentration of 1.5 X 10(6) cells/ml for 3 days on F-10 medium supplemented with 10% fetal calf serum. The supernatant fluids from the cell cultures were bioassayed for bone resorption-stimulating activity (BRSA) by an assay based on the release of 45Ca from prelabeled fetal mouse forearm bones in organ culture according to Raisz's method. The supernatant fluid of cultures from both patients which showed marked BRSA was nondialyzable through a dialysis membrane with a molecular weight cutoff of 3500. Parathyroid hormone and prostaglandins were not detectable in the supernatant fluids of the leukemic cell cultures. In one patient, BRSA was measured twice and found to be decreased to a normal level when the patient was in hematological remission with a normal calcium level (8.3 mg/dl). These results suggest that the hypercalcemia observed in patients with ATL is due, in part, to a bone resorption-stimulating factor which is produced by leukemic T-cell lymphocytes.

Adult↗
PubMed1984

[A case of multiple myeloma treated with long-term peritoneal dialysis].

A 54-year-old female was admitted to our hospital in November 1979 with a history of lumbago and proteinuria. She was diagnosed as suffering from chronic renal failure (CRF) due to multiple myeloma (Bence-Jones kappa type). Intermittent COP therapy (a combination of cyclophosphamide, vincristine and prednisolone) and peritoneal dialysis were started. Her clinical condition was improved and well controlled by peritoneal dialysis over a period of 26 months until she died of pneumonia. Renal failure due to multiple myeloma has been a very poor prognosis. Hemodialysis has been used for renal failure much more frequently than peritoneal dialysis. In this case, control of chronic renal failure due to multiple myeloma with peritoneal dialysis was successfully performed over a long period of time. Peritoneal dialysis, therefore, may be an effective therapy for CRF due to multiple myeloma.

Bence Jones Protein↗
PubMed1984

Ferritin immunoelectron microscopic localization of 5'-nucleotidase on rat liver cell surface.

Rat livers were prefixed by perfusion with 0.6% glutaraldehyde and briefly homogenized with a Teflon-glass homogenizer. The prefixed cells isolated by low-speed centrifugation in high yield effectively preserved the original polygonal shape and polarity. These cells were incubated with ferritin-antibody conjugates monospecific for rat liver 5'-nucleotidase, and the localization of the enzymes on the surface of hepatocytes and endothelial cells was quantitatively investigated. It was revealed that the surface density of 5'-nucleotidase is much higher on the bile canalicular surface than on the sinusoidal surface and only a few ferritin particles were detected on the lateral surface. On the bile canalicular surface ferritin particles were almost exclusively found on the microvilli in larger clusters. Similar distribution was also observed on the sinusoidal surface but the size of cluster was much smaller. On both surfaces many fewer ferritin particles were found on the intermicrovillar region, including the coated pits region, than on the microvillar region. Ferritin particles were also found on the endothelial cell surface.

5'-Nucleotidase↗
PubMed1984

High-dose chemotherapy with frozen autologous marrow transplantation in patients with poor-prognosis tumors.

One hundred and ninety patients with poor-prognosis tumors, mainly advanced solid cancers were treated with a first course of high-dose chemotherapy. One hundred nine of them received frozen autologous bone marrow transplantation (FABMT) a total of 160 times. Thirty-four of the 109 patients were given a second course, and five of the 34 received a third course followed by FABMT. Eighty-four patients (77%) showed subjective and/or objective remissions; however, 59 (54%) died from the original malignant tumor, 27 (23%) from profound acquired immune deficiency, and the remaining 18 patients are now in follow-up. A comparison between the patients who received the high-dose chemotherapy followed by FABMT and those who received the high-dose chemotherapy alone because of the absence of marked myelosuppression remains as a future subject for study. We experienced some important cases, in which FABMT played a decisive role in rescuing the marrow abrasion from toxicity of the anticancer drugs. We feel certain that FABMT can accelerate hemopoietic recovery in cancer patients after high-dose chemotherapy. We also conclude that FABMT is an interesting approach to provide hope to the poor-prognosis patients who have failed or respond to conventional chemotherapy and radiotherapy, although FABMT is still undergoing clinical trial and only in specialized hospitals.

Adult↗