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Biomedical subjects

S Erdem

Publications and source records attributed to S Erdem.

103 records · Page 6Linked to original sources
PubMedDate not supplied

Aplastic anemia due to chemicals and drugs: a study of 108 patients.

To illustrate the etiologic role of drugs and chemicals in the development of aplastic anemia, we analyzed 108 cases of aplastic anemia among 3,715 hematologic patients during a ten-year period at the hematology section of Istanbul Medical School. Among these 3,715 patients, 695 had leukemia, a result indicating the relative rarity of aplastic anemia as compared with leukemia. Of the 108 patients, 58.3% were male and 41.7% were female. Their ages ranged from six months to 82 years. Pancytopenia was severe in 42.6% of the patients, and moderate or mild in 57.4%. Bone marrow was hypocellular in 84 patients, normocellular in 16, and hypercellular in eight. In 52 (48.1%) of the patients with aplastic anemia, the following etiologic factors were implicated: benzene (25 patients), antirheumatic drugs (ten), chloramphenicol (four), chloramphenicol plus hepatitis or chromosome anomalies (two), thiamphenicol plus sulfonamide (one), antituberculous drugs (three), daraprim (three), insecticides (two), hepatitis (one), and sulfonamide (one). Data indicate that the degree of bone-marrow cellularity is not always related to functional capacity, and numerous agents may have etiologic roles in the development of aplastic anemia.

Adolescent↗
PubMedDate not supplied

Is leptin associated with serum lipid profile or any other parameters of blood biochemistry in post-menopausal women with osteoporosis?

We investigated the relationship between serum leptin concentration, serum lipid profile and other blood biochemistry parameters in healthy post-menopausal women. Blood samples for analysis of serum leptin concentration, blood biochemistry and hormonal status, and urine samples for calcium measurement were taken from 122 women. No significant correlation was found between serum leptin concentration and serum lipid profile. The concentration of serum leptin was significantly associated with body mass index (BMI), luteinizing hormone (LH) and alanine transaminase (ALT). BMI was found to be a statistically significant independent factor for serum leptin concentration. We conclude that leptin was not associated with serum lipids and lipoproteins in post-menopausal women. Leptin was associated with BMI, ALT and LH, however, with BMI being an independent predictor of leptin concentration. There was a relationship between LH and serum leptin concentration even after menopause, and ALT correlated with serum leptin concentration through BMI.

Adult↗
PubMedDate not supplied

[Total laryngo-tracheo-esophageal cleft with situs inversus totalis, aplasia of the right diaphragm and hypoplasia of the lung on the right side].

A report is presented on a newborn with congenital malformations of the respiratory and gastrointestinal tract associated with total laryngo-tracheo-oesophageal cleft (type III). The history, the clinical course with respiratory distress after birth, the intra vitam diagnostic procedures with x-ray and laryngoscopy and the autopsy are reported. Additionally a situs inversus totalis, an aplasia of the right diaphragm and a hypoplasia of the lung on the right side were found. To the best of our knowledge this type of association has not been previously reported.

Diaphragm↗
PubMedDate not supplied

The distribution of haptoglobin types in various regions of Turkey.

The distribution of haptoglobin (Hp) types and the gene frequencies of Hp1 in various regions' of Turkey are discussed. The Hp1 gene frequency ranged between 20.4 percent for Turks living in the eastern part of Turkey and 32.6 percent in those who either are at present living in or have migrated from Western Thrace. Generally, the Hp1 gene frequency in the Turkish population is 26.5 percent, a figure similar to that recorded for Asians. Minor variations in the Hp1 gene frequencies in various parts of Turkey may be assumed to have been caused in certain regions by intermingling with the local populations.

Adult↗