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Biomedical subjects

S E Whitmore

Publications and source records attributed to S E Whitmore.

50 records · Page 3Linked to original sources
PubMed1995

Acute effect of topical minoxidil on digital blood flow in patients with Raynaud's phenomenon.

OBJECTIVE: Raynaud's phenomenon is a relatively common disorder for which highly effective, well tolerated treatment has yet to be developed. Minoxidil, a potent vasodilator which, on a single application to the scalp causes significant local cutaneous vasodilation, was selected for study in primary Raynaud's phenomenon. METHODS: Ten subjects were enrolled in a randomized double blind, placebo controlled acute challenge crossover trial. Single applications of topical minoxidil 5% solution and placebo were made to each subject's fingers on 2 separate occasions, and measures of digital skin temperature, systolic blood pressure, and laser Doppler flow were obtained, before and after acute cold challenge. RESULTS: Digital skin temperature, systolic blood pressure, and laser Doppler flow both before and after cold challenge were not improved by pretreatment with topical minoxidil 5% solution. CONCLUSION: In individuals with primary Raynaud's phenomenon, a single application of minoxidil 5% solution to the fingers is not effective in improving baseline digital blood flow or cold tolerance.

Administration, Cutaneous↗
PubMed1994

Ovarian cancer in patients with dermatomyositis.

A consensus regarding adequate screening to detect early malignancy in the setting of dermatomyositis (DMM) has yet to be reached. This issue is particularly relevant with regard to ovarian cancer, as early detection with routine examinations, ultrasound, and abdominal CT may not be successful. Four of 15 women diagnosed with and seen in our department for DMM between 1986 and 1993 were subsequently diagnosed with metastatic papillary serous ovarian carcinoma. One additional patient developed metastatic pelvic papillary adenocarcinoma, believed to be of ovarian origin. These diagnoses of advanced cancer were unexpected, as all women had undergone repeated cancer screenings beyond what is normally recommended for patients with DMM. The 5 women were strikingly similar in their initial presentations and subsequent courses. In each, the diagnosis of DMM was delayed from 2 to 10 months, as they were initially misdiagnosed with a photoinduced or contact dermatitis. All except 1 had severe, recalcitrant skin disease despite attempted therapy with antimalarial and immunosuppressive agents. All 4 patients who survived the postoperative period after tumor debulking showed either improvement or resolution of their DMM. It appears that women with DMM have an increased incidence of ovarian cancer, which is usually diagnosed months to a few years (range, 0 d to 6 y) after DMM has been diagnosed. Although recommendations have been made regarding cancer screening in these individuals, recommendations for initial and surveillance examinations vary from routine history and physical examination to evaluations including extensive radiologic evaluation.(ABSTRACT TRUNCATED AT 250 WORDS)

Age of Onset↗
PubMed1994

Should atopic individuals be patch tested?

Although it appears that the incidence of allergic contact dermatitis is lower in patients with atopic dermatitis than in patients with other forms of dermatitis, studies have shown that a significant number of atopics demonstrate allergic contact dermatitis on testing. This article presents a review of the larger studies that have been performed in atopic individuals as well as recommendations for patch testing.

Adult↗
PubMed1994

Hypopigmented mycosis fungoides.

BACKGROUND: Only five cases of purely macular hypopigmented mycosis fungoides have been published in the literature. These patients all had clinical evidence of disease 7 months to 10 years prior to histologic diagnosis, suggesting that this clinical presentation of mycosis fungoides is easily misdiagnosed. OBSERVATIONS: Three African-American males, ages 9, 15, and 22 years, were found to have mycosis fungoides on evaluation of skin biopsy specimens after initially being clinically diagnosed with, and treated for, pityriasis alba. All three had typical histopathologic changes and cell marker studies showing a relative loss of the CD7 antigen, which is normally present on the majority of T cells. One patient who was treated with methoxsalen plus UV light (PUVA) therapy had clearance of his disease clinically and histologically. CONCLUSION: From the literature, it would appear that macular hypopigmented mycosis fungoides is exceptionally rare. This perceived rarity may be inaccurate due to either relative underreporting, incorrect diagnoses, or both. From the eight patients now reported to date, it may be said that hypopigmented mycosis fungoides may be seen in nonwhite individuals and more often than not, has onset before age 20 years.

Adolescent↗
PubMed1992

The importance of proper vehicle selection in the detection of minoxidil sensitivity.

BACKGROUND: The correct selection of vehicles for patch testing specific substances is essential in the evaluation of suspected allergic contact dermatitis. A reaction to a chemical may be dependent not only on the concentration tested but also on the vehicle in which it is tested. In cases of suspected allergic contact dermatitis to minoxidil, propylene glycol, and alcohol formulations, patch testing is usually done with the formulation of minoxidil in alcohol and/or minoxidil in petrolatum. OBSERVATIONS: An acute contact dermatitis of the scalp developed in a 34-year-old white man while he was using minoxidil (Rogaine [2% minoxidil in a solution of alcohol 60% vol/vol, propylene glycol, and water]) solution. Patch testing with 2% minoxidil in alcohol and 2% minoxidil in petrolatum showed no reaction, while both Rogaine solution and 2% minoxidil in propylene glycol produced papulovesicular plaques. CONCLUSIONS: Patch testing in cases of suspected minoxidil allergic contact dermatitis should include testing with minoxidil in propylene glycol. Omitting this testing may cause diagnoses and therapeutic formulation alternatives to go unrecognized.

Adult↗
PubMed1991

Late-onset nevus of Ota.

We report a patient with a type IB nevus of Ota whose lesion did not appear until she was thirty years old. To our knowledge, this represents the oldest age of a patient at clinical onset of nevus of Ota. The diagnosis, implications, and treatment of nevus of Ota are reviewed.

Adult↗