Biomedical subjects

S E Larsson

Publications and source records attributed to S E Larsson.

At least 19 recordsLinked to original sources

PubMed1992

Electromyographic changes in work-related myalgia of the trapezius muscle.

In 11 patients, all women, 21-55 years of age, with unilateral work-related myalgia of the trapezius muscle, the right and left trapezius muscles were examined simultaneously for electromyogram (EMG) signs of localized muscle fatigue. All patients were tested with 0-kg hand load for 5 min, holding the arms straight at 90 degrees of elevation in the scapular plane. Only 4 of the patients tolerated exposure to higher load levels. They were tested with 1 kg hand load for 3 min and 2 kg hand load for 2 min, with a period of rest of 30 min between the trials. The EMG mean power frequency (MPF) and root mean square (rms) were calculated. Data were normalized with the initial value as a reference and regression analyses were performed. On both sides a decrease of MPF and an increase of rms were found with increasing time and load, i.e. classical EMG signs of localized muscle fatigue. Compared with the nonaffected side smaller changes were found on the affected side, possibly due to pain inhibition, impaired microcirculation and biochemical changes along the muscle fibres. At 0-kg hand load we found no change of MPF on either side despite subjective feelings of fatigue and pain. We interpreted these findings as an indication of reduced capacity of the affected trapezius muscle to sustain static load with early development of pain-associated local fatigue.

Adult↗

PubMed1992

Locomotion status and costs in destructive rheumatoid arthritis. A comprehensive study of 82 patients from a population of 13,000.

Clinical manifestations (locomotion score) and annual costs were studied in a population-based cohort of 82 patients with rheumatoid arthritis fulfilling five to eight American Rheumatological Association's (ARA) criteria. The total costs were SEK 4.9 million: respectively 56 and 44 percent direct and indirect costs. The costs were correlated with total, as well as subjective and objective, locomotion scores, which assess separately impairment, disability, and handicap from the disease (WHO 1980). Patients below 65 years had higher costs-predominantly as an indirect cost due to loss of work-than older patients. Elderly rheumatoid arthritis (RA) patients had a low score and high costs for medical and social services' care, but they had no indirect costs. Patients with a low locomotion score had received previous hospital treatment averaging 89 days. The need of hospital treatment was strongly correlated with low locomotion score. The mean annual patient's costs were about SEK 60,000, but above this for younger patients. When compared with patients with a mild affliction (score 91-100), patients with moderate manifestations, i.e., with a score of 70-90, had five times higher costs, whereas those with severe manifestations, with a score below 50, had 20 times higher costs.

Adult↗

PubMed1992

Work-related chronic neck impairment. Neck motion analysis in female traverse crane operators.

Twenty-one female steel industry traverse crane operators with long-term sick-leave (3 (1-8) years) due to chronic neck disability underwent careful analysis of case history, physical status and electrogoniometric three-dimensional recordings of active neck motion. Results were compared with those from working female crane operators having identical work posture and tasks and, further, with a group of working female clerks. The sick-listed crane operators had previous frequent contacts with the primary health care because of complaints from the neck and back. In comparison with the reference groups, the sick-listed crane operators showed tenderness of the trapezius and levator scapulae muscles and a short neck stature in combination with impaired active neck motion range with reduced motion speed. The motion pattern was however unchanged. The findings are consistent with the clinical picture of chronic neck myalgia that persisted despite long-term absence from the previous exposure to high static work load upon the neck-shoulders.

Adult↗

PubMed1991

Suramin inhibits growth of human osteosarcoma xenografts in nude mice.

The effect of suramin on tumor growth and morphology in two different human osteosarcoma xenografts (L-I OSM and L-II OSM) grown in BALB/cA-nu/nu mice was studied. Suramin (total dose, 720 mg/kg) given by i.p. injection (60 mg/kg/dose) for up to 9 weeks significantly inhibited osteosarcoma cell growth in both tumors, suramin-treated tumors showing only one-third or less of the volume of nontreated controls. Cell cycle distribution of tumor cells measured by DNA flow cytometry demonstrated that suramin treated caused accumulation of cells in the S and G2 phases of the cell cycle, in both L-I OSM and L-II OSM. In the aneuploid L-II OSM tumor suramin preferentially inhibited the growth of aneuploid cells, leading to a decrease in the ratio of aneuploid to diploid cells. Both osteosarcomas retained their histological appearance and the liver, spleen, heart, and kidneys of the treated animals were unaffected by suramin. These results are compatible with the view that suramin inhibits the growth of human osteosarcomas by cytostatic effects.

Animals↗

PubMed1991

Cell proliferation rate and tumor volume in human osteosarcoma during exposure to methotrexate. A study on tissue transplants in nude mice.

The growth inhibitory effect of methotrexate (MTX) on osteosarcoma cells was studied in dysthymic nude mice bearing tumor transplants obtained from a patient before (PRE-CHEM) and after (POST-CHEM) preoperative chemotherapy for osteosarcoma of the distal femur. Cell proliferation was analyzed by autoradiographic evaluation of the fraction of labeled cells after continuous administration of 3H-thymidine for seven days. Histomorphometric analysis of the tissue distribution of cells in the partly ossified tumors was performed. The PRE-CHEM sarcoma transplants showed a significant reduction of labeled interphases from 52 to 1.7 percent upon daily MTX treatment of the mice as compared to controls. In contrast, MTX treatment did not inhibit cell proliferation in the POST-CHEM tumor transplants in which approximately 70 percent of the cells were labeled. Tumor volume increased by 65 and 54 percent in the MTX-treated PRE- and POST-CHEM groups, respectively. During the same eight-day period, control transplant volume increased by 30 percent (PRE-CHEM) and 20 percent (POST-CHEM). Tumor cell densities in the MTX-treated groups were reduced by a factor of approximately 11 in the PRE-CHEM transplants and by a factor of approximately 1.5 in the POST-CHEM transplants. The results show that in this patient the osteosarcoma cells had changed their responsiveness to MTX during the preoperative chemotherapy period. In both the MTX-sensitive and non-sensitive tumor lines, exposure to MTX induced increased tumor volume by increasing the extra cellular matrix volume, irrespective of the neoplastic cell proliferation rate. This effect of MTX was most pronounced in the MTX-sensitive tumor line. These results indicate that in the clinical situation it is difficult to judge the response to chemotherapy even from morphologic parameters.

Adolescent↗

PubMed1991

Dynamic posturography in cervical vertigo.

Cervical vertigo, the entity of neck disorder and associated vestibular symptoms, was investigated in 15 suspected subjects and results were compared with 15 age-matched controls. A modified dynamic posturography investigation with different head positions was used. Head position was recorded 3-dimensionally with electrogoniometry. Differences on a sway-referenced forceplate were found.

Adult↗

PubMed1991

Functional improvement and costs of hip and knee arthroplasty in destructive rheumatoid arthritis.

Functional improvement and costs were analysed in 54 patients after 23 hip and 31 knee arthroplasties. All patients had destructive RA (ARA criteria 5-8). Mean stay at the surgical department was 15 and 26 days respectively, regardless of preoperative locomotion status, sex, or age, but additional in-patient rehabilitation was significantly longer after knee than hip arthroplasty (11 days and 4 days, respectively). Subjective and objective status as evaluated with total locomotion score showed significant improvement 6 months after operation. The degree of over-all improvement was equal for men and women, for all age groups, and for the different score groups. Quality of life improved with pain relief, improved sleep, and improved walking ability. The mean total costs were 34,902 SEK for hip and 56,200 SEK for knee replacement, including in-patient rehabilitation. Costs for home help were reduced from 693,600 SEK to 479,400 SEK. Severely disabled patients showed satisfactory improvement, but did not reach the functional level achieved by patients who were less disabled at the time of operation. Costs were not significantly higher for the former category.

Adult↗

PubMed1991

Joint disorders and walking disability in Sweden by the year 2000. Epidemiologic studies of a Swedish community.

The prevalence of joint complaints with walking disability, as well as clinically diagnosed hip and knee diseases, in Sweden in the year 2000 was calculated from data from a population survey that we made in a Swedish community (Atvidaberg) in 1986. The population was representative of that of the whole country. Among all 5,259 persons aged 45 years and older, 35 percent reported long-lasting joint complaints. The prevalence of clinically diagnosed degenerative joint disease was 14 percent, that of extraarticular disease 12 percent, inflammatory joint disease 2.4 percent, arthralgia 1.4 percent, and collagenoses 0.5 percent. From the official estimations of the Swedish 8.5 million population as to age classes and sex by the year 2000, joint complaints can be foreseen in 1.2 million inhabitants, representing a total increase of 0.16 million persons. The number of patients with destructive rheumatoid arthritis can be estimated at 58,000 in the year 2000.

Aged↗

PubMed1990

Three-dimensional analysis of neck motion. A clinical method.

A clinical method is described for simultaneous recording of neck motion in three different planes using electrogoniometric equipment. Results correlated with those reported in the literature regarding separate examinations of the motion range in the separate planes. Correlation with conventional gravity goniometer was good as to flexion-extension and lateral flexion, whereas, for rotation, a compass goniometer showed poor correlation and, also, unsatisfactory reproducibility. The electrogoniometric recordings showed good correlation with radiographically determined flexion-extension occiput-C7 as well as lateral flexion C1-T1. Graphical recordings made in the three different planes demonstrated in detail the different movements that contribute to the complex motion pattern of the neck. This three-dimensional motion analysis affords a more objective functional evaluation of common neck disorders that may supplement radiographic examination.

Adult↗

PubMed1990

Rheumatoid arthritis evaluated by locomotion score. A population study.

The effects of rheumatoid arthritis on locomotion status were assessed in an epidemiologically representative Swedish population sample. In a steady community of 12,707 inhabitants, 82 patients were found fulfilling ARA criteria 5-8 (Rome 1961). Prevalence was 0.51% for men, 0.78 for women and 0.65 in the overall population (unpublished observation). The ratio women:men was 1:0.67. Mean age was 65 (30-92) years, age at onset 47 (7-91) and disease duration 19 (1-65) years. All patients were evaluated clinically with total locomotion score (best = 100, worst = 0). This was 72 (24-96) overall; 76 (24-96) for men and 68 (30-94) for women. Among the ages above 64, women had significantly (p less than 0.02) lower scores than men. Mean subjective score (max. 100) was 62 (4-93) overall; 67 (5-93) for men and 58 (9-92) for women, and objective score (max. 100) 82 (23-100); 85 (44-99) for men and 78 (23-100) for women. Over the years, a total of 108 reconstructive operations had been performed on 36 out of the 82 patients (44%). Indication for further reconstructive surgery was found in as many as 56% of the patients, including 58 major joint replacements. Scores for patients in need of operation were significantly lower than those for those who were considered not to need an operation.

Adult↗

PubMed1990

Hand function and total locomotion status in rheumatoid arthritis. An epidemiologic study.

The effects of destructive rheumatoid arthritis (RA) on hand function, as well as total locomotion status, were assessed in a Swedish population sample. In a community of 12,707 inhabitants, 82 were found with RA fulfilling ARA criteria 5-8, i.e., a prevalence of 0.7 percent. Seventy-seven of the 82 cases were evaluated with Sollerman's hand function test and our total locomotion score. The mean hand score (max. 80) was 61 (0-78), with no difference between the right and the left hand or between men and women. Hand function worsened with increasing age of the patient, as well as with increasing disease duration. It was highly correlated with the total locomotion status of the patient. A high correlation was found between hand function and hospital care. However, total medical or social costs for these patients were not related to hand function, but merely to the status of the lower extremities.

Adult↗

PubMed1990

Elbow arthroplasty in rheumatoid arthritis. Function after 1-2 years in 20 cases.

The function of the hand and arm was studied after total elbow arthroplasty in a consecutive series of 18 rheumatoid patients with a total of 20 primary arthroplasties and one revision. Extensive clinical evaluation with locomotion score and Sollerman's hand function test was undertaken preoperatively and at 6 months postoperatively. The mean flexion range increased 25 degrees and extension lag decreased 5 degrees. Pain relief was achieved in all the cases, and 16 of 20 primary operated on elbows became fully painfree. Hand function score (max. 80) improved from 52 to 64, upper extremity score (max. 100) from 57 to 68 and subjective score (max. 100) from 46 to 58. Complications were 2 cases of ulnar nerve paresthesia and 1 epicondylar fissure.

Adult↗

PubMed1990

Chronic trapezius myalgia. Morphology and blood flow studied in 17 patients.

Bilateral open biopsies from the painful upper part of the trapezius muscle were studied in 17 patients with localized chronic myalgia related to static load during repetitive assembly work. Isolated pathologic ragged red fibers were related to the presence of myalgia. The phenomenon indicating disturbed mitochondrial function was confined to the Type 1 fibers. Using a laser-Doppler flowmeter, the muscle blood flow was recorded in the exposed muscle before a biopsy was taken. Pain was assessed and graded as the difference between the two sides, as was the presence of ragged red fibers. The myalgia correlated with reduced local blood flow: the greater the pain difference, the greater the reduction in blood flow. There was a correlation between the presence of mitochondrial changes and reduced muscle blood flow.

Adult↗

PubMed1989

Locomotion score in rheumatoid arthritis.

A total locomotion score suited for clinical evaluation of patients with rheumatoid arthritis was developed and fulfilled the 1980 criteria of WHO. The grading system distinguished a subjective score for pain and ability from an objective score for physical signs, and it assessed the upper and lower extremities separately. The total locomotion score consisted of the total subjective and total objective scores combined. The three total assessments each showed a linear relationship to Steinbrocker's four functional classes when tested in 106 rheumatoid patients with ARA criteria 5-8. The interobserver reliability was good. The multifactorial assessment data were monitored by a computer.

Activities of Daily Living↗

PubMed1988

Muscle changes in work-related chronic myalgia.

Muscle biopsies from the descending portion of the trapezius muscle were studied in 9 healthy subjects and in 10 patients with localized chronic myalgia related to static load during repetitive assembly work for 16 (10-31) years, with 10 (4-26) months of sick leave at the time of biopsy. Both categories showed isolated atrophic muscle fibers and occasional abnormal fibers with internally situated nuclei, some variation in fiber diameter, and fiber splitting. Fibers with a "moth-eaten" appearance due to a multifocal loss of oxidative enzyme activity were frequent both in the healthy and in the myalgic individuals. In contrast, isolated pathologic "ragged red" fibers were only found in the cases with myalgia (8 of 10), strongly suggesting mitochondrial damage. The phenomenon was confined to the Type 1 fibers. The frequency of Type 1 fibers was increased. Levels of adenosine triphosphate and adenosine diphosphate were reduced in myalgia patients, whereas lactate, pyruvate, and glycogen levels were normal, as well as phosphoryl creatine and total creatine.

Adult↗

PubMed1979

Bone mineral content in the proximal tibia measured by computer tomography.

With a slight modification of the EMI MK1 scanner a sensitive method for examination of the bone mineral content in the proximal tibia was achieved. The method allows an estimation of the amount of trabecular and cortical bone as well as their mineral content. The anatomic structure of the bone substance is demonstrated, differing in osteoporosis and osteomalacia. The reproducibility is acceptable.

Bone and Bones↗

PubMed1979

Extra-osseous osteosarcoma: a clinical and histopathological study of four cases.

Four cases of extra-osseous osteosarcoma were found among 242 cases recorded as osteosarcoma in the Swedish Cancer Registry during the years 1958 to 1968. The tumours occurred in middle-aged and elderly patients. Three of the tumours were situated in the proximal part of the thigh and one in the scapular region. Histopathologically, all tumours were subclassified as osteoblastic osteosarcomas. The patients were treated by primary local excision which in one case was followed by a radical en bloc excision of the entire tumour bed. All cases subjected to simple excision died of metastatic disease five to twenty-four months after diagnosis. The patient treated by en bloc excision is alive and apparently free from disease fourteen years after diagnosis.

Adult↗

PubMed1979

Removal of the third thoracic vertebra and partial lung resection for a radioresistant giant-cell tumour of the spine.

Total removal of the third thoracic vertebra and partial removal of the second and fourth vertebrae together with partial lung resection were successfully performed in a twenty-two-year-old woman with a large, radioresistant, giant-cell tumour which completely surrounded the spinal cord and extended over the left lung. On admission, the patient was in her third episode of paraplegia, the two previous episodes having been temporarily relieved after decompression of the spinal cord by laminectomy and partial removal of the tumour. Three and a half months after operation she was discharged walking without support and with normal sphincter control. Two years later she is free of symptoms and the neurological status is practically normal. Clinical and radiological examinations show no signs of recurrence of the tumour.

Adult↗