Search PubMed⌕ Search

Biomedical subjects

S Dumitriu

Publications and source records attributed to S Dumitriu.

25 records · Page 2Linked to original sources
PubMedDate not supplied

[Immunofluorescence studies in the pathogeny of parodontal disease].

One of the current question in this field is that of the possibility for parodontal disease to be an autoimmune disease. There is no clear answer as yet in the specialized literature, and no coherent and complete concepts. Starting from the existing data the authors have carried out immunological studies in patients with parodontal disease, considering the chronic, recidivating aspects of this disturbance, even after a complex therapy, and removal of pathological structures. They attempted to investigate the autoimmune components of the disease, and have employed immunofluorescent techniques of the indirect type for the study of gingival fragments without lesions obtained from patients with parodontopathies. The data obtained have demonstrated, besides the presence at the surface of the epithelium of stable immune complexes, that could be the effect of bacterial antigenic material, and cell fluorescence in the epithelium and the chorion, a fluorescence that was superposed on the respective tissue architecture. These data suggest implication of autoimmune mechanism in parodontal disease, and can explain, in the frame of the clinical aspects of chronic marginal parodontopathies, the auto-aggressive character, and the self-maintenance of these processes in certain conditions, even when an adequate therapy has been applied.

Autoimmune Diseases↗
PubMedDate not supplied

[Apiphytotherapeutic original preparations in the treatment of chronic marginal parodontopathies. A clinical and microbiological study].

The paper presents results obtained by the treatment of chronic marginal parodontopathies with natural products of apiarian derivatives and vegetal extracts. These are original preparations such as Proparodont, sage extracts, watercress extracts, etc., by comparison with other similar existing products, and with zinc chloride. The clinical study evaluated the "inflammation status of the marginal prodontium" on the basis of variations in the PMA index. The microbiological study has established the bacteriostatic and the bactericidal activities of the products employed. The results obtained stress the high antimicrobial activity of the original products called Proparodont, and stress its antimycotic effects, especially against Candida albicans. The blackwort (Symphytum off.) extracts have a good repair effect, especially after surgical procedures. The complex original products based on propolis and vegetal extracts are indicated in the treatment of inflammatory lesions of the gingivo-parodontal tissues, and of the buccal mucosa. They also have antimicrobial effects, as well as antimycotic, antiinflammatory and antiscar effects. They de not have side effects which are characteristic for other medicinal drugs employed in the treatment of chronic marginal parodontopathies.

Anti-Infective Agents↗
PubMedDate not supplied

[Passive hemagglutination test in the serodiagnosis of syphilis].

Passive haemagglutination test with pathogenic Treponema pallidum antigen in the serodiagnosis of syphilis, carried out on 752 sera (518 syphilitic patients and 234 subjects without evidence of syphilis) showed a greater general sensitivity as compared the cardiolipin tests and complement fixation test with Reiter protein antigen, and lower, to immunofluorescence (FTA--ABS). Its specificity is relatively lower than that of the cardiolopin and treponemal tests. Associated with the cardiolipin test it may be preferably used for the detection of syphilis, and moreover, passive haemagglutination may confirm the diagnosis in case of weak positive results with the FTA--ABS test. The latter is, however, essential for problem cases.

Antigens, Bacterial↗
PubMedDate not supplied

Isolation and speciation of Prevotella strains from periodontal abscesses.

The aims of the study were to isolate and to identify at species level the Prevotella strains in pus samples collected by needle aspiration from 25 Romanian patients with periodontal abscesses. Gram-stained smears and cultures on selective and nonselective media were performed from each of the 25 pus samples. The isolates were identified on the basis of Gram staining, cultural characteristics and standard biochemical reactions. The Gram-negative anaerobic bacilli isolates were biochemically characterized and identified at species level using the Rapid ID 32 A system (Bio Mérieux, France). Fifteen Prevotella isolates belonging to one of the following species: P. melaninogenica, P. denticola, P. oralis, P. loescheii and P. bivia were recovered. All Prevotella isolates reacted similarly in 20 tests in the Rapid ID 32 A system. The P. melaninogenica strain showed approximately the same biochemical profile and only two sugar fermentation tests were not constantly positive. The study confirmed that Prevotella is often involved in periodontal abscesses (> 50% of the cases) in association with other anaerobic or/and aerobic bacteria. P. melaninogenica was the most frequently isolated Prevotella species from the investigated cases.

Humans↗