The role of cytosine nucleotides in liver damage due to organophosphates.
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Adenosine Triphosphate↗
Biomedical subjects
S Domschke
Publications and source records attributed to S Domschke.
Kinetics of duodenal ulcer healing: effect of treatment with cimetidine.
In a double-blind trial, 12 in-patients with endoscopically proven duodenal ulceration were treated with cimetidine (0.8 g daily) or placebo. Ulcer sizes were assessed endoscopically before treatment and at weekly intervals during treatment. Duodenal-ulcer healing was significantly more rapid in patients on cimetidine than in those receiving the placebo (p less than 0.0005): half-times of ulcer healing were about 6 days (on cimetidine) as compared to about 20 days (on placebo). No untoward clinical or laboratory effects were observed.
Anti-Ulcer Agents↗
Nitinol esophageal stents: new designs and clinical indications.
PURPOSE: To evaluate the clinical use of covered and noncovered, knitted nitinol stents in patients presenting new stent indications. METHODS: Self-expandable, knitted nitinol stents were implanted in four patients for treatment of dysphagia. In two patients who had malignant strictures and had esophago-respiratory fistulae and in one patient with an esophagocutaneous fistula, polytetrafluoroethylene (PTFE)-covered stents were implanted. One patient received a noncovered stent, but a retrograde approach through a percutaneous endoscopic gastrostomy (PEG) fistula had to be chosen for recanalization of an esophageal occlusion. Two patients received stents for treatment of benign strictures. RESULTS: Recanalization of the stricture and stent implantation were performed under fluoroscopic control without any procedure-related morbidity or mortality. Dysphagia improved in all patients and the esophageal fistulae could be sealed off by covered stents. During a maximum follow-up of 18 months, there was no stent migration or esophageal perforation. Complications observed were stent stenosis due to food impaction (1/4) and benign stent stenosis (2/2). Most complications could be treated by the interventional radiologist. CONCLUSION: Self-expandable, covered Nitinol stents provide an option for the treatment of dysphagia combined with esophageal fistulae. In combination with interventional radiology techniques, even complex strictures are accessible. For benign strictures, the value of stent treatment has not yet been proven.
Adult↗
Endogenous motilin and lower esophageal sphincter pressure in man: clue to an association.
In man (n = 5), after intraduodenal instillation of 50 ml of 0.1 N hydrochloric acid the lower esophageal sphincter pressure (LESP) and plasma motilin concentrations rise concomitantly exceeding basal by about 80% (p less than 0.025) and 90% (p less than 0.05), respectively, at 3 to 4 minutes. These results suggest that the increase in LESP after duodenal acidification may be brought about by endogenously released motilin.
Adult↗