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Biomedical subjects

S Dokumov

Publications and source records attributed to S Dokumov.

At least 19 recordsLinked to original sources
PubMed1995

Premenopausal bleeding associated with hyperprolactinaemia.

A sample of 54 climacteric women (mean age 48.1 years) being treated for premenopausal bleeding was assessed. The mean serum prolactin value was 23.04 ng/ml. A separate group of 28 hyperprolactinaemic patients showing a mean level of 34.43 mg/ml was compared. No abnormalities of the sella turcica at skull X-ray examination were disclosed. Predominant anovulatory bleeding was found in the endometrial tissue specimens obtained by curettage. The mean serum prolactin level of the climacteric women was significantly increased in comparison with that of 35 healthy women with normal menstrual cycle (P < 0.001). An influence of age on serum prolactin levels in women was found (r = 0.406). Similar results were not reported until now, although this study does not help to explain exactly the role of elevated prolactin level in climacteric impairment of ovarian function.

Female↗
PubMed1989

[Diagnosis and treatment of idiopathic hypogonadotropic hypogonadism in men based on a clinical case].

A patient with tertiary hypogonadotropic hypogonadism was followed up for many years. On the basis of this observation the possibilities for a correct diagnosis with the gonadoliberin test are pointed out. A positive effect of the treatment with gonadotropic hormones, especially on the spermatogenesis, is established. Several other new therapeutic means which can be applied in these patients are discussed.

Adult↗
PubMed1983

[Serum gonadotropins and histomorphology in polycystic ovaries].

FSH and LH levels as well as the ratio of LH to FSH before and after wedge resection were checked in 25 women with polycystic ovaries in connection with histomorphology. The probands were subdivided histomorphologically by the following three groups: 1. diffuse hyperplasia and luteinized theca interna; 2. foci of hyperplastic and luteinized stroma cells; 2. various corpus luteum-formations. A correlation was found to exist between gonadotropin levels in serum and histomorphological changes. FSH levels, for example, were much lower in the third group, while postoperative LH levels remained to be higher in cases of more strongly pronounced follicular and stromal luteinisation and more strongly manifest changes in corpus luteum-formations.

Adolescent↗
PubMed1981

Serum gastrin I concentrations of mother and newborn immediately after birth.

Serum gastrin I (GLU-GLY-PRO-TRYP-LEU(GLU)6-ALA-[formula, see text]-GLY-TRY-MET-ASP-PHE-CO-NH2) concentrations were investigated by radioimmunoassay in 50 mothers and their newborn infants immediately after birth. The mean serum gastrin concentration in maternal blood was 52.80 +/- 13.37 (SD) pg/ml, and in cord blood 84.12 +/- 42.90 (SD) pg/ml. Both values were significantly higher than serum gastrin levels found in normal, healthy, nonpregnant women (Mean +/- SD = 32.34 +/- 18.35 pg/ml). There were no statistically significant differences in the cord serum gastrin concentrations with respect to sex, weight and length of the infant and age and parity of the mother.

Adolescent↗
PubMed1978

[Gonadotropin secretion in patients with testicular feminization].

FSH and LH were functionally examined in 5 women with feminizing testis and compared with the peripheral sex steroid hormones. The oestradiol levels were found decreased, while those of testosteron were elevated. FSH disclosed no significant differences while the basal levels of LH and its stimulatory response to LH-RH were increased in the patients.

Adolescent↗