Biomedical subjects
Publications and source records attributed to S Dobi.
Schistosomiasis is a worm disease which causes a high mortality rate all over the world. The life span of worms can be 20-30 years, so if the acute phase of the disease is not fatal very often late complications can happen. Here we demonstrate two patients who suffered from different late complications of Schistosomiasis imported to our country. These two cases show the difficulty of diagnosis and therapy of such illnesses.
There has only a small number of invasive amoebiasis cases occurred in Hungary up to now. Introducing two of our cases we would like to call attention on these cases coming mainly from tropical countries or having been just transiently there invasive amoebiasis should also be considered. Modern diagnostic imaging technics are of importance in differential diagnosis in showing antibodies against amoebas (!) because amoebas frequently cannot be directly shown from the patients in the invasive stage. Both ulcerous amoebic colitis and amoebic liver abscesses can be treated with drugs affecting amoebas in deep tissues (metronidazole, emetine, and its derivates, etc.).
Various types of fish-poisoning mainly occur in tropical areas. Saxitoxin, tetrodotoxin, scombrotoxin and clupeotoxin are heat labile while ciguatoxin, in contrast, is heat stable thus it may be the source of severe poisoning even in case of thorough cooking and baking. In December 1987 a mass alimentary poisoning occurred following ingestion of fish meat in a group returning from Cuba. The most severe case was admitted to our department with symptoms of extended paresis. Diagnosis of ciguatoxin poisoning was established based upon the history, clinical features and laboratory results. Nowadays exotic, remote "Fish-poisoning" cases have to be taken into consideration even in our country.
Results of this study showed that in a considerable number of patients with duodenal ulcer a globulin of the IgG class was responsible for the enhancement of HCl secretion. This secretagogue globulin appeared to combine directly with the H2 receptors of the parietal cells thereby increasing hydrochloric acid output without the formation of antigen-antibody complex.
It is suggested on the ground of the present study that in a number of cases of duodenal ulcer it is an immunoglobulin of the class IgG which, as a stimulating factor, accounts for overproduction of gastric HCl. This immunoglobulin takes effect by direct attachment to the parietal cells.
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The authors make a case report of a male patient, 58 of age, whose complaints started 37 years ago; inspite of an operation, repeated medical check-ups and treatment, they had no other choice but to perform a further laparotomy when the patient presented himself with progressive cachexia and signs of an acute abdomen. Taking the history, the operative and histological findings of the patient into consideration, the correct diagnosis could be made: Whipple's disease. The presence of this condition was also proven by postoperative X-rays and immunological examinations. The patient has been restored to health after a year's antibiotic treatment. An impaired defensive ability, mainly of the immune and macrophage system can be proven to exist in Whipple's disease. Two main tasks are essential: 1) to hold the patient under constant control and 2) to continue research with the aim of finding ways of immunocorrection.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.