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Biomedical subjects

S Ding

Publications and source records attributed to S Ding.

79 records · Page 5Linked to original sources
PubMed1990

The nucleotide sequence of the genomic RNA of kennedya yellow mosaic tymovirus-Jervis Bay isolate: relationships with potex- and carlaviruses.

The nucleotide sequence of the genomic RNA of kennedya yellow mosaic tymovirus-Jervis Bay isolate (KYMV-JB) has been determined. The genome of KYMV-JB is 6362 nucleotide residues long and encodes three major open reading frames. The genomic organization and the encoded proteins of KYMV-JB are very similar to those of three other tymoviruses that have recently been reported. Sequence comparisons revealed that the possible replicase proteins of tymoviruses are closely related to those of potexviruses and carlaviruses, suggesting a close evolutionary relationship among these viruses, despite differences in their genome organization and particle morphology.

Amino Acid Sequence↗
PubMed1990

[Studies of rapid detection of drug-resistance of Mycobacterium by gas chromatography].

This test is based on the physiologic character of mycobacterium, which produces carbon dioxide (CO2) during its growth, Löwenstein-Jensen media CO2 contents-were measured by gas chromatography for determining drug-resistance of mycobacteria. This was compared with the routine method. Seventy-eight mycobacteria were isolated from suspected tuberculosis patients for the experiment. Our data suggested that the accordance rates of both methods were 83.3%. Gas chromatography is a simple, rapid and accurate method for detecting drug-resistance. The results can be obtained twenty days earlier than by the routine method.

Antitubercular Agents↗
PubMed1990

[Establishment of standard strains of serotypes (groups) of Streptococcus pneumoniae in China].

Streptococcus pneumoniae is an important human pathogen which is responsible for life-threatening infections such as pneumonia, bacteremia and meningitis as well as for less severe but highly prevalent diseases such as otitis media and sinusitis. The number of serogroups (types) of Streptococcus pneumoniae found in the world is total 46 groups or 83 types according to typing system of Statens Serum Institute, Copenhagen, Denmark. The standard strains established in our lab of 42 groups or 67 types distributed in 17 different regions in China. The significance of this study is that two of the new serotypes (10C, 16A) are first reported in the literature in which the microbes were the agents causing pneumococcal infections. Our standard strains also include some serotypes on rare occasions such as 19C and 22A and 33C which have been found only in Asia. Our findings not only increase the total number of known types of pneumococci from 83 to 85, but also indicate that China has made progress in the field of pneumococcal research. It is the first time to report establishing a series of standard strains of pneumococci involving many serotypes (groups) in China. The work is necessary as a preliminary for pneumococcal disease prevention and treatment. The standard strains listed here with providing the resource of strain and scientific basis for developing vaccine and biological products.

China↗
PubMed1989

Measurement of serum transferrin by the gamma-gamma perturbed angular correlation method. Differences between normal and cancer serum.

In this work, the average perturbed angular correlation integral attenuation factor G2 of the transferrin in the serums from the normals and the patients with liver cancer were determined using time integral perturbed angular correlation method (PAC). The average values of G2 were 0.1945 +/- 0.0155 for the cancer serum transferrin and 0.2865 +/- 0.0411 for the normal serum transferrin. The difference between these two groups is significant. Mathematical deduction and theoretical analysis suggested that the equivalent radius of the transferrin molecules in the serum of cancer patients becomes smaller than normal, because of a change in the molecular conformation. Similar results were also observed in experiments with rat serum transferrin.

Gamma Rays↗
PubMedDate not supplied

Fat suppression at 7T using a surface coil: application of an adiabatic half-passage chemical shift selective radiofrequency pulse.

The selective suppression of fat using chemical shift selective (CHESS) sinc, gaussian presaturation, or binomial radiofrequency pulses are widely implemented techniques in magnetic resonance imaging. For applications wherein transmitter coils that generate inhomogeneous magnetic (B1), fields are used (e.g., surface coils), adiabatic radiofrequency pulses that are less susceptible to spatial variations in B1 amplitude will improve the spatial homogeneity of spin excitation angle. Herein, we describe the application of an adiabatic half-passage hyperbolic secant CHESS pulse suitable for acquiring fat-suppressed magnetic resonance images with surface coils on high-field systems. Images obtained from a water/fat phantom and from the abdominal region of a rat are presented indicating excellent suppression of fat signal from the entire coil-sensitive volume.

Abdomen↗
PubMedDate not supplied

An allelic variant at the ATM locus is implicated in breast cancer susceptibility.

We have tested a simple procedure, disease association by locus stratification, for identifying breast cancer patients with pathogenetic allelic variants at several candidate loci. The strategy was based on the assumption of epistatic interactions of the candidates. We analyzed 66 independent cases from sib pairs affected with breast cancer that had previously been collected during an investigation of pathogenetic-allele-sharing at the HRAS1 mini-satellite locus. An exon 24 polymorphism of ATM, substituting arginine for proline was associated with breast cancer in these cases with an overall odds ratio of 4.5 (95% confidence interval, 1.2-20.5, nominal p = 0.02, 2-tail Fisher exact test). In the presence of a rare HRAS1 allele, the odds ratio increased to 6.9 (95% CI, 1.2-38.3, p = 0.03). Thus, our procedure identified at least one allelic variant of ATM associated with breast cancer, and indicated that the ATM locus may interact with HRAS1.

Adult↗