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Biomedical subjects

S Dietrich

Publications and source records attributed to S Dietrich.

124 records · Page 7Linked to original sources
PubMed1986

Osteogenesis imperfecta type III. Delineation of the phenotype with reference to genetic heterogeneity.

The existence of a rare form of osteogenesis imperfecta, OI type III, has been postulated. This is characterized by autosomal recessive inheritance with neonatal manifestations of bone fragility or deformability. It is usually nonlethal. Studies of some 345 pedigrees of OI in the last 8 years confirm that patients falling into this group are rare. They should be distinguished as a special group within the group of OI subjects with a progressively deforming OI phenotype delineated in previous publications [Sillence et al, 1979a, b]. The OI type III phenotype does not necessarily equate with progressively deforming OI, and probably only a proportion of cases with severe deformity and normal sclerae have OI type III. On the other hand, distinction between these patients and those with a milder form of perinatally lethal OI type II might be difficult. Whereas the natural history of skeletal deformity and fractures in patients with OI type III has certain similarities, variable severity between families indicates that OI type III is likely to be genetically heterogeneous.

Adolescent↗
PubMed1984

Monitoring the iodine dose.

The administration of large amounts of iodinated contrast media can result in acute renal failure. Many diagnostic examinations, including pyelography, computed tomography and digital vascular imaging, require the injection of significant amounts of contrast media. Additionally, these examinations may be performed within 24-48 hours of each other, increasing the likelihood of a dose-induced acute renal failure. To avoid this complication, we have developed and implemented a system to monitor and control the patient's dose of iodine. This system effectively alerts individuals to the iodine dose the patient has received within the last 48 hours. The information is being used to compile a study concerning the relationship between iodine dose and the occurrence of acute renal failure.

Acute Kidney Injury↗
PubMed1982

Bowel training for children with neurogenic dysfunction: a follow-up.

Fifty children with neurogenic bowel dysfunction and stool incontinence received in patient bowel regulation training and were interviewed an average of 1.2 years later. Twenty-eight were males. Mean age was 13.5 years (range 5.6 to 18.9 years). Of the 50 children, 27 (54%) had myelomeningocele; 21 (2%), spinal cord lesion; and 27/2 (4%), repaired imperforate ani. Frequency of stool incontinence decreased from 1.8 episodes for the week prior to discharge to 0.9 episodes for the same period preceding follow-up interview (p less than 0.025). Significant changes occurred in the recommended bowel program in order to accommodate individual home environment and family life styles. Contributory factors accounting for these changes are discussed in light of specific guidelines for the rehabilitation team.

Adolescent↗
PubMedDate not supplied

Effects of speech and language disorders on raters' perceptions.

Using semantic differential scales with nine trait pairs, 465 students at two universities rated five descriptions, one portraying an individual without a disorder and four depicting communicative disorders. Statistical analyses indicated that the descriptions with no disorder and with a language disorder were rated significantly lower in ambition than those depicting stuttering, voice, or articulation disorders. Other differences emerged when the raters were divided by geographical location and age. Location was a significant factor in the responses for the traits of social adjustment, employability, and ambition. Age of respondent correlated significantly with ratings of tension and employability.

Adolescent↗
PubMedDate not supplied

Perceptions of communicative disorders: verification and specification of rater variables.

UNLABELLED: Using semantic differential scales with nine trait pairs, 600 students at three universities rated five descriptions, one depicting an individual without a disorder and four portraying individuals with communicative disorders. Statistical analyses indicated that the description with no disorder was rated as significantly less ambitious than the described articulation disorder. Other differences emerged when raters were divided by gender and age. Male subjects rated the portrayed individuals as more highly stressed than did females. A significant negative correlation was found for age of respondent and ratings of self-esteem. Results support previous research suggesting that rater gender and age impact perceptions of communicative disorders. LEARNING OUTCOMES: As a result of this activity, the participant will be able to: (1) identify the different means by which investigators have studied the stereotyping of people with communicative disorders, (2) discuss how listeners perceive those with and without communicative disorders, and (3) identify listener traits that may be associated with negative perceptions of people with communicative disorders.

Adolescent↗
PubMedDate not supplied

A multistate outbreak of Escherichia coli O157:H7 infections linked to alfalfa sprouts grown from contaminated seeds.

A multistate outbreak of Escherichia coli O157:H7 infections occurred in the United States in June and July 1997. Two concurrent outbreaks were investigated through independent case-control studies in Michigan and Virginia and by subtyping isolates with pulsed-field gel electrophoresis (PFGE). Isolates from 85 persons were indistinguishable by PFGE. Alfalfa sprouts were the only exposure associated with E. coli O157:H7 infection in both Michigan and Virginia. Seeds used for sprouting were traced back to one common lot harvested in Idaho. New subtyping tools such as PFGE used in this investigation are essential to link isolated infections to a single outbreak.

Adolescent↗