Biomedical subjects
S Dhar
Publications and source records attributed to S Dhar.
Involvement of nails in discoid lupus erythematosus.
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Erythema nodosum leprosum in a case of histoid leprosy.
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Failed lumbar spinal surgery.
Failures and poor results of 160 patients after lumbar spinal surgery between 1980 and 1984 were analysed retrospectively. A self-rated questionnaire carried out 12 months after operation revealed 20 poor results; these occurred most commonly after multiple operations, decompression and fusion as compared to disc excision. The commonest cause was failure to recognise abnormal pain behaviour before operation. A more careful preoperative assessment should reduce the incidence of failure.
Chilblain lupus erythematosus and lupus pernio--the same entity?
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Capitellocondylar total elbow replacement for rheumatoid arthritis.
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Rupture of the symphysis pubis during labor.
Two cases of spontaneous rupture of the symphysis pubis (SP) during delivery are reported. The separations were associated with considerable pain, swelling, and tenderness over the symphysis pubis and were confirmed roentgenographically. Both patients were treated conservatively with bed rest, mostly in the lateral decubitus position, within pelvic binders. Immobilization was discontinued when they were pain free. The SP separations remained in reduced positions. The patients were essentially asymptomatic and walked normally. Conservative treatment followed by early mobilization is adequate treatment for SP separations.
Role of tear secretory IgA in hard contact lens-related changes in the tarsal conjunctiva.
The role of tear secretory IgA in contact lens-related conjunctival changes was investigated in 40 subjects (80 eyes) who wore polymethyl methacrylate (PMMA) contact lenses and 10 subjects (20 eyes) who did not wear contact lenses. The eyes in the contact lens group had significantly higher tear IgA levels than the control eyes (p < 0.05). We were not able to demonstrate a relation between increased IgA levels and the presence of symptoms or duration of contact lens wear. Increased IgA levels were correlated to papilla formation in the contact lens group. A rise in tear IgA levels seems to be the first abnormal change related to papilla formation in patients who wear PMMA contact lenses.
Role of bacterial flora in the pathogenesis & management of atopic dermatitis.
The carriage state of Staphylococcus aureus and its role in the pathogenesis and management of atopic dermatitis were evaluated in 50 patients, aged 3 months to 12 yr. An equal number of age and sex matched controls were also studied. The positivity of Staph.aureus in patients with atopic dermatitis was 50 per cent from eczematous skin, 34 per cent from anterior nares and 26 per cent from normal skin. In controls, the comparative figures were 14 per cent from anterior nares and 10 per cent from normal skin. After institution of oral erythromycin or cloxacillin therapy (according to sensitivity), the colony counts dropped to 18 per cent from eczematous skin, 14 per cent from anterior nares and 8 per cent from normal skin after one week and to zero after 3 wk. This was associated with significant clinical improvement. The results of this study suggest that Staph. aureus aggravates the eczematous process in patients with atopic dermatitis and antibiotics decrease the severity and are useful in long term prognosis of the disease.
Evaluation of minor clinical features of atopic dermatitis.
The diagnostic significance of 19 previously proposed minor features of atopic dermatitis was evaluated. The frequency of these features was studied in 50 patients with typical atopic dermatitis compared to that in 50 control subjects. The ages of all individuals ranged from 3 months to 12 years. Six of the minor features, chelitis, nipple eczema, perifollicular accentuation, white dermographism, recurrent conjunctivitis, and anterior neck folds, were encountered as often in patients as in controls. Two additional features that were of diagnostic significance were diffuse scaling of the scalp and infraauricular fissuring.
Ionization potentials of cobalt and nickel ions in the local-spin-density approximation.
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Anomalous broadening of angle-resolved photoemission linewidths on W(011).
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Clinicopathological correlation of hard contact lens related changes in tarsal conjunctiva by impression cytology.
Eighty contact lens wearing eyes and 20 non-contact lens wearing eyes are investigated for biomicroscopic changes and impression cytology. Symptomatic contact lens wearing eyes demonstrate significantly more prevalent and severe papillary conjunctival changes than in asymptomatic contact lens wearing eyes. Impression cytological changes demonstrate squamous metaplasia and goblet cell loss which is seen to increase with increasing duration of lens wear.
Early open reduction for congenital dislocation of the hip.
We have reviewed 82 children with congenital dislocation of the hip, after treatment by anterior open reduction followed by derotation femoral osteotomy. The clinical and radiological results were significantly better in the group that had open reduction before the appearance of the capital femoral epiphysis; this group also had a lower incidence of avascular necrosis. We conclude that, when it is clearly indicated, the earlier an open reduction is carried out the better the results.
Chemoimmunoprophylaxis against bovine tropical theileriosis in young calves: a comparison between buparvaquone and long-acting oxytetracycline.
Eighteen seven to 21-day-old crossbred (Bos taurus cross Bos indicus) calves were allocated to four groups (A to D). Groups A and B each consisted of six calves and groups C and D three calves each. Each calf in groups A, B and C was inoculated with ground-up tick supernate (GUTS) equivalent to two infected acini prepared from Theileria annulata-infected Hyalomma anatolicum anatolicum. Each calf in group A was also given a single intramuscular injection of buparvaquone, 2.5 mg kg-1 bodyweight simultaneously with GUTS, whereas each calf in group B was given a single intramuscular injection of long-acting oxytetracycline, 20 mg kg-1 bodyweight following inoculation of GUTS. In calves of group A clinicopathological reactions were negligible, whereas in calves of group B mild to severe reactions were observed resulting in the death of three of the six calves. All the calves of group C (infected, untreated controls) died of acute theileriosis. All the surviving calves of groups A and B withstood a lethal homologous challenge given on day 30 after immunisation, indicating no difference in the immune status of the surviving calves of the two groups. Group D, challenge control, all calves died of theileriosis within 18 days of challenge.
Implication of nonintegral occupation number and Fermi-Dirac statistics in the local-spin-density approximation applied to finite systems.
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Partial purification and characterization of phospholipase C from Yersinia enterocolitica.
About 34% of the strains of Yersinia enterocolitica isolated from raw milk were found to produce lecithinase. A selected strain produced phospholipase C at 22 degrees C and 37 degrees C; production was optimum at 37 degrees C in the stationary phase (14-16 h). A decrease in phospholipase C activity at various storage temperatures (-5 degrees C, 4 degrees C, 37 degrees C) was also observed, although the enzyme was active over a wide range of temperature (5-65 degrees C) and pH (3.5-7.5). The phospholipase C was partially purified by ammonium sulphate precipitation and Sephadex column chromatography, and characterized.