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S Devaux

Publications and source records attributed to S Devaux.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Initial results of tm-PAH studies in children with kidney transplants].

In 15 children 2 months to 5 years after a transplantation of a cadaver kidney the renal function was determined by means of a clearance- and Tm-PAH-examination. Only in 4 children the Tm-PAH reached the normal value of a kidney. The calculation of the glomerulo-tubular balance results in increased values. The result for the relative tubular blood supply is normal. Compared with the values of children with an overcome haemolytic-uraemic syndrome or with a chronic glomerulonephritis or pyelonephritis shows that the renal function in children who underwent a transplantation similarly behaves as in a chronic pyelonephritis.

Aminohippuric Acids↗
PubMed1984

[A new method for the determination of the maximal tubular transport of p-aminohippuric acid without urine analysis in children with transplanted kidney].

For the clearance investigations of children who underwent renal transplant operations methods without indwelling catheters in the urinary bladder are necessary. The determination of GFR and ERPF takes place by means of single injection of radioactively labelled clearance substances. The maximum tubular secretory function may be established by means of the Tm PAH. Up to now for this purpose the quantitative determination of PAH in the urine was necessary. By means of an on principle other method by determination of the 125J-hippuran clearance under infusion of PAH the Tm-PAH may be indirectly calculated without investigation of the urine. In nine children with renal diseases the parallel determination was performed with classical and new method (r = 0.89, p less than 0.01), in order to prove the good correspondence of the results of the two methods. The Tm PAH in seven children who underwent renal transplant operations shows at first an at ERPF relatively decreased, after several years a relatively increased Tm PAH.

Aminohippuric Acids↗
PubMed1981

[Uremic plasma as cause of metabolic changes in red blood cells].

Under the influence of the uraemic plasma a number of changes of the metabolism of red blood cells develop. By means of cross experiments with the help of filtrability, of sulf-haemoglobin formation and the 125-iodine-hippuran intake the influence of the uraemic plasma and of the plasma of healthy persons on the red blood cells of children who undergo a chronic haemodialysis as well as of healthy adults (cross experiments) was examined. The red blood cells of the control persons after an incubation at 37 degrees and 60 or 180 minutes showed approximately the same changes of filtrability, formation of sulf-haemoglobin and 125-iodine-hippuran as the red blood cells of the patients with incubation in the autologous plasma. Disturbances of the filtrability and the formation of sulf-haemoglobin could be proved in the uraemic red blood cells still after reincubation in the normal plasma, though clearly reduced. Only in 125-iodine-hippuran a normalisation could be got. Filtrability and formation of sulf-haemoglobin apparently comprise more complex processes which essentially influence the life span of the red blood cells, whereas the 125-iodine-hippuran value characterizes only a part of the metabolism of the red blood cells, the passive transport of anions.

Adult↗
PubMed1981

[Effect of uremic plasma fractions of different molecular sizes on the filterability of red blood cells].

Behaviour of the filtration of red blood cells (rbc) passed through a filter paper was investigated. The rbc were incubated in fractions of blood plasma with different molecular mass (MM). By means of an Amicon membrane XM-50 the separation of plasma from healthy and uremic patients (children) was performed into two parts of different molecular sizes one of these was the concentrate (MM more than 50 000 = K) and the other was the ultrafiltrate (MM below 50 000 = UF). By a second step the UF was divided (Amicon membrane UM-50 into an UF1 (MM below 500) and into an UF2 (MM 500 to 50 000). In addition a hemofiltrate (MM below 5 000) was used for the incubation too. This hemofiltrate was made form pooled plasma of healthy and uremic patients, respectively. Rbc was incubated in both different fractions of plasma and hemofiltrate at a temperature of 37 degrees C and for a duration of 60 min. The pH-level and the osmolality were physiological. Under the influence of uremic UF the flexibility of rbc was clearly decreased. The UF1 had the most effect of the decrease of flexibility. Therefore the small substances which are easy dialysable play also an important role in the damage of rbc in the uremia.

Child↗
PubMed1980

[Hemodialysis in children with kidney failure in the GDR].

From our experiences with more than 9.000 haemodialyses in children we render the following three general conclusions: 1. The chronic haemodialysis and the transplantation of a kidney stood the test in the therapy of chronic renal insufficiency in childhood. 2. The most favourable conditions for the performance of the treatment with dialysis in children consist within a special paediatric institution which is achieved by the formation of dialysis centres for children in the GDR. 3. The success of the treatment with dialysis essentially depends on the preparation of the child and on the good cooperation of all persons participating in the treatment. The care system in the GDR which was built up together with the working team children nephrology in 1970 essentially contributes to this fact.

Adolescent↗