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Biomedical subjects

S Deutsch

Publications and source records attributed to S Deutsch.

At least 73 records · Page 4Linked to original sources
PubMed1981

A simplified version of Kunihiko Fukushima's Neocognitron.

In a recent paper, Kunihiko Fukushima described a "Neocognitron: a self-organizing neural network model for a mechanism of pattern recognition unaffected by shift in position". The present paper presents a simplified version of the neocognitron. Whereas the latter employs a 16 x 16-element visual field which requires computer simulation, the simplified model uses a 10-element one-dimensional visual field. Two input examples are analyzed: a white sheet which is gradually lowered over a black background, and a white center dot which gradually stretches vertically in both directions until it covers the black background. The model demonstrates invariance with respect to lateral shift.

Animals↗
PubMed1980

Previously unrecognized diabetes mellitus in sexually impotent men.

Three-hour oral glucose tolerance tests (GTTs) were performed for 58 men with secondary impotence (SI), 63 with normal sexual function (NL), and 69 with premature ejaculation (PRE). All were apparently nondiabetic. Diagnoses of diabetes and impaired glucose tolerance were based on serum glucose levels during GTT as recently defined by the National Diabetes Data Group. Covariance analysis corrected for weight and age differences. Mean glucose levels in patients with SI were significantly higher at one and two hours after glucose ingestion than in the other groups. Seven patients with SI (12.1%) were found to have diabetes. The three groups did not differ notably in frequency of impaired glucose tolerance. Inorganic serum phosphate levels were lower for the SI group. The high frequency of diabetes in subjects with SI who have no diabetic symptoms (12.1%) suggests that localized neuropathy or penile ischemia may produce impotence in otherwise asymptomatic patients.

Adult↗
PubMed1980

Fat-free mass, total body water, and intracellular water in the aged rat.

Total body water (TBW) and intracellular water (ICW = TBW minus extracellular water), when related to fat-free body mass (FFB), were recently observed to remain stable in healthy aged men and women. To expand these findings, a group of male Sprague-Dawley rats was followed from weaning to death. The design minimized several perturbations common to aging studies. At about 100-day intervals from 297 to 888 days, representative animals were killed for chemical studies. TBW/FFB was stable from 362 to 715 days, then significantly higher at 800 and 888 days. Extracellular water content of the fat-free body (ECW/FFB) increased significantly during middle life (362--579 days), then remained stable through 888 days. Changes of ICW/FFB were not significant. Aside from a uniquely higher value at 638 days, protein content did not differ significantly at any age. The stability of these major constituents suggested approximate maintenance of cell mass in healthy rats at late ages, a conclusion supported by additional observations of this colony and of an aged human population. We are unable to confirm the hypothesis that loss of FFB is part of the normal aging process.

Aging↗
PubMed1980

Seven-electrode EER stimulator-monitor for ambulatory monkeys.

An electrical evoked response (EER) stimulator-monitor for ambulatory monkeys is described. Seven time-multiplexed electrodes are used. The unit switches between stimulus and monitor modes at a 100-Hz rate. In the stimulus mode, 3.5 V peak, 0.45-ms pulses are applied at a 100-Hz rate to any electrode selected by means of toggle switches on a remote control panel. In the monitor mode, low-frequency -3 dB cutoff occurs at 0.2 Hz. A 20-MHz carrier is used as a local superheterodyne oscillator during the stimulus period, and as an FM transmitter during the monitor period. Three mercury cells supply 4 V at 10 mA. The unit weighs 80 g. It is 5.7 x 5 x 2.5 cm in size.

Animals↗
PubMed1978

Potentiation of vincristine cytotoxicity by hormones: corticosteroids, androgens, estrogens and progestins.

Using an in vitro system to evaluate the simultaneous use of two drugs, we previously have confirmed the synergism of vincristine and prednisolone cytotoxicity against lymphoid cells. Experiments were now carried out to determine whether other steroid hormones can be substituted for prednisolone. Partial or complete potentiation of vincristine cytotoxicity comparable to that achieved by the addition of prednisolone was observed when the latter drug was replaced by a variety of mineralocorticoids (aldosterone, desoxycorticosterone and fludrocortisone), glucocorticoids (hydrocortisone, dexamethasone), androgens (testosterone, methyltestosterone, androsterone, dehydroepiandrosterone, etiocholanolone), estrogens (estrone, 17-beta estradiol) and progestins (progesterone, pregnanediol). No potentiation of cytotoxicity was observed when nonsteroidal hormones (thyroxin, ACTH) were added to vincristine. It is concluded that a wide variety of compounds with the basic perhydrocyclopentanophenanthrene nucleus of the steroid molecule are capable of enhancing the cytotoxicity achieved with vincristine.

Adrenal Cortex Hormones↗
PubMed1978

The utility and selection of laboratory tests in the diagnosis of the polycystic ovary syndrome.

Fourteen patients with clinically diagnosed and surgically documented polycystic ovarian (Stein-Leventhal) disease (PCOD) and 16 normal control women were studied to identify the laboratory test or tests that, from the clinician's point of view, are most likely to aid in the nonsurgical diagnosis of the disease. A single random morning blood specimen was assayed in all cases for testosterone, epitestosterone, androstenedione, FSH and LH. The mean testosterone level for the PCOD patients was significantly greater (p less than 0.001) than that for the controls, with 50% of the patients showing elevated levels. Androstenedione showed a similar pattern, but mean epitestosterone levels were not significantly different from controls. FSH was not significantly different, but LH levels were significantly higher than controls (p less than 0.005), with 10 of 13 (77%) demonstrating elevated levels. A strong positive correlation was also found between the degree of virilization and the levels of LH, testosterone and androstenedione. This study suggests that the most useful diagnostic laboratory assay from a single drawing of blood is the serum LH; the only other useful test is testosterone and/or androstenedione. These data do not support other reports of elevated levels of epitestosterone or decreased values of FSH in PCOD.

17-Ketosteroids↗
PubMed1976

Plasma levels of fractionated estrogens and pituitary hormones in endometrial carcinoma.

Plasma levels of estrone (E1), estradiol-17beta (E2), and estriol (E3), as well as follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin were measured in 30 control subjects and in 20 postmenopausal patients with adenocarcinoma of the endometrium. Within the sensitivity of the assay (5 to 10 pg.), no E3 was found. Mean levels of E1 and E2 in the patients with carcinoma (42.64+/-3.8 (S.E.M.) and 17.3+/-1.7 (S.E.M.) pg. per mililiter) were significantly higher than those measured in the control subjects (E1=26.97+/-2.4 (S.E.M.) pg. per mililiter, p less than 0.001; E2=12.08+/-1.2 (S.E.M.) pg. per milliliter, p less than 0.02). Effects of age, diabetic status, and obesity were taken into consideration. Significant differences in FSH and marginally significant differences in prolactin levels were observed between the two groups. Mean levels of FSH, LH, and prolactin in the control group and the group with adenocarcinoma, respectively, were as follows: FSH=152.3+/-7.0 (S.E.M.) versus 98.1+/-8.9 (S.E.M.) mI.U. per milliliter, p less than 0.001; LH=64.7+/-3.1 (S.E.M.) versus 66.5+/-5.2 mI.U. per milliliter, difference not significant; and prolactin=14.3+/-0.9 (S.E.M.) versus 17.8+/1.7 (S.E.M.) ng. per milliliter, p less than 0.06. These results, as well as previously reported alterations in human growth hormone secretion, suggest aberrations in hypothalamic function in endometrial carcinoma.

Age Factors↗