Intravenous line infection caused by Corynebacterium CDC group ANF-1.
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Biomedical subjects
Publications and source records attributed to S Dealler.
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Green-top, or unpasteurised, milk is an increasing source of illness. A case of a previously unreported cause of septic arthritis of the hip joint, secondary to the ingestion of raw milk is reported.
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The prion protein (PrP), is found only in the brain of animals infected with TSE. It is a modified form of a normal protein (PrPn) produced from the genome of the animal. The modification prevents breakdown by proteinases and hence its total chemical or physical structure is unknown. The finding of fibre-like structures in microglia and neurones that cross-react with antibodies produced against PrP and the rapid turnover of PrPn may mean that normal biochemical pathway PrPn forms can join a crystal seed of PrP to produce these fibres. This hypothesis, that the modification of PrP is physical rather than chemical, avoids the major problems with theories of PrP as the infective agent.
Bovine spongiform encephalopathy (BSE) is one of the transmissible spongiform encephalopathies (TSE) that are currently known to the authors to affect only mammals, including man. The diseases are progressive, fatal paralyses and dementias, for which there are no methods of certain diagnosis and no treatment. In this review the disease in cattle, the mode of transfer of these TSEs between animals by mouth, the possible presence of infective agents in the food that we eat, the resistance of BSE to cooking, and the likelihood that humans may become infected are discussed. The origins of BSE, whether from sheep, from cows, or as a mutation are considered. Whatever the origin of BSE, a substantial danger for man exists. Creutzfeld-Jakob disease (CJD), a TSE of man, may have been derived from eating infected animal tissue in the past. The possibility that this was of bovine origin and the implications that this would have for BSE infected meat in human food are discussed.
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Haematuria in an elderly patient is a common urological complaint. A patient is described in whom xanthogranulomatous pyelonephritis presented as unilateral renal vein thrombosis. So far as the author is aware, this is the first report of such an association.