Search PubMed⌕ Search

Biomedical subjects

S Davis

Publications and source records attributed to S Davis.

At least 469 records · Page 26Linked to original sources
PubMed1980

Mitogen stimulation of chronic lymphocytic leukemic lymphocytes: defective phytohemagglutinin stimulation independent of immunologic cell surface markers.

Peripheral blood lymphocytes (PBL) from 107 untreated patients with chronic lymphocytic leukemia (CLL) were analyzed for the presence of surface immunoglobulin (Ig) and the ability to form rosettes with sheep erythrocytes (SRBC). Four groups were identified based on the cell surface markers: (1) 81 patients' PBL expressed primarily IgM kappa or IgM lambda, 4 further patients' PBL expressed IgM with equal percentages of kappa and lambda surface markers; (2) 13 patients had equal percentages of PBL expressing lg and SRBC receptors; (3) 6 patients' PBL primarily formed rosettes with SRBCs, and (4) in 3 patients and the majority of cells had no detectable markers (null cells). Lymphocytes from all patients within each group were tested for their ability to respond to phytohemagglutinin (PHA) and pokeweed mitogen (PWM). The maximum response in PHA-stimulated normal cell cultures appeared at 2--3 days; for PWM-stimulated cultures, maximal response was at 3--5 days. CLL cultures from all patients in each of the four groups required 5--7 days to develop a maximal PHA response. The response of CLL lymphocytes in all groups to PWM stimulation was similar to normal lymphocytes. Thus, the abnormal PHA response of CLL lymphocytes was independent of the presence or pattern of cell surface markers.

Adult↗
PubMed1980

Acute renal tubular dysfunction following cis-dichlorodiammine platinum therapy.

Following single, high dose (3 mg/kg) DDP therapy seven patients with head and neck cancer developed significant serum electrolyte disturbances. Hypocalcemia, hypomagnesemia, hypokalemia, and hypophosphatemia were the most clinically significant electrolyte abnormalities. Renal clearance studies support a pathologic mechanism of a diffuse renal tubular leakage not associated with renal failure.

Acute Kidney Injury↗
PubMed1979

Myasthenia gravis and lymphoma. A clinical and immunological association.

Myasthenia gravis and lymphoma rarely coexist, but the occurrence of myasthenia shortly after the treatment of a patient with poorly differentiated nodular lymphoma suggested that an immunological disorder may have contributed to the development of both diseases; the fundamental defects in this association may be impaired immunological surveillance and impaired regulation of immune responses to autoantigens. The finding of T-cell immunodeificiency, including profound T-cell lymphopenia, impaired delayed hypersensitivity responses, and failure to a thymus-dependent antibody response to Salmonella adelaide flagellin, is consistent with this hypothesis.

Autoantibodies↗
PubMed1979

Computed tomography of intracerebral toruloma.

The CT features of intracerebral toruloma are described and the clinicopathological features briefly reviewed. The diagnosis of intracerebral toruloma should be considered when pulmonary opacities are associated with multiple intracerebral enhancing masses.

Adult↗
PubMed1979

A case of pulsating proptosis.

The long-term follow-up of a case of unilateral pulsating proptosis is reported. The clinical signs in this patient were due to a defect in the bony wall of the orbit which is an unusual manifestation of neurofibromatosis.

Adult↗
PubMed1979

Elevated prolactin levels in bronchogenic carcinoma.

The frequency and significance of hyperprolactinemia was studied in 21 consecutive, untreated male patients with bronchogenic carcinoma. Seven patients (33%) were found to have elevated serum prolactin (hPRL) levels. No correlation was demonstrated between increased hPRL levels, tissue histology, or tumor burden. L-dopa suppression and/or TRH stimulation tests were obtained in three untreated patients with hyperprolactinemia. The results of these tests were considered normal suggesting hypothalamic control.

Adenocarcinoma↗
PubMed1978

Circulating inhibitors of blood coagulation associated with procainamide-induced lupus erythematosus.

We studied a patient being treated with procainamide in whom we observed a high antinuclear antibody titer and prolonged activated partial thromboplastin (PTT), prothrombin (PT), and Stypven times (ST). Serum antibody concentrations against single-stranded DNA were elevated while those aginst native DNA were not elevated, suggesting the procainamide-induced lupus syndrome. Dilution of the patient's plasma with normal plasma failed to correct the PTT and PT, indicating the presence of an inhibitor(s) to blood coagulation. The anticoagulant activity was associated with the IgG fraction of the patient's serum. Addition of purified or partially purified human factors IX, X, VIII, VII, XIa, prekallikrein, high molecular weight kininogen, or phospholipids to the patient's plasma failed to correct the PTT, PT, or ST; however, purified human factor XII and prothrombin corrected the PTT and ST, respectively. These results indicate that production of antibodies directed against antigenic determinants on coagulation proteins can be a manifestation of procainamide-induced lupus erythematosus.

Blood Coagulation↗