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Biomedical subjects

S Daum

Publications and source records attributed to S Daum.

At least 55 records · Page 3Linked to original sources
PubMed1982

Early tumor and leukemia response to alkyllysophospholipids in a phase I study.

In a phase I study on the toxicity and toleration of alkyllysophospholipids, tumor and leukemia responses have been noted in the first treated patients. Six patients with solid malignomas of different histologic types and one patient with acute myeloid leukemia are evaluable so far. All of them suffered from metastatic or wide-spread disease, were refractory to adequate polychemotherapy or other treatment modalities, or have been found untreatable because of poor general condition. Four cases revealed objective tumor and leukemia response with a minor response in a hypernephroma, two partial remissions in nonsmall cell bronchogenic carcinomas and reduction of leukemic blasts to less than 10% in acute myeloid leukemia. Limiting toxicity started with doses of 20 mg/kg given daily showing transient injury of renal and liver functions.

Adolescent↗
PubMed1980

[The mucoid impaction and the "mucous bronchogram" (author's transl)].

Intrabronchial retention of large plugs of inspissated mucous in cases of disturbed bronchial secretion and impaired clearing mechanism leads often to chronic inflammation and to formation of "proximal" bronchiectasis. Mucoid impaction may occur in many bronchial diseases and is radiologically characterized by the so-called "mucous bronchogram".

Adult↗
PubMed1980

Evaluation of mixed venous oxygenation on the basis of arterial oxygen tension in chronic lung diseases.

The mixed venous oxygenation in relation to arterial oxygen tension was evaluated in the control group (30 subjects) and in patients with chronic obstructive lung disease (COLD; 56 subjects) and fibrosing alveolitis (FA; 20 subjects). The mixed venous hypoxia was found in 28.4% of patients with COLD and in 40% of patients with FA. The arterial oxygen tension values below which mixed venous hypoxia can be expected were below 55 mm Hg in normocapnic and below 46 mm Hg in hypercapnic patients. The values of mixed venous oxygen tension correlated significantly with the coefficient of oxygen delivery in the control group (r = 0.84; p less than 0.001) and in all patients taken together (r = 0.69; p less than 0.001). The finding of mixed venous hypoxia, which is an approximate index of tissue oxygenation, might have some clinical implications.

Adolescent↗
PubMed1979

Asbestos disease in maintenance workers of the chemical industry.

In several large groups of workers employed in chemical plants, chest x-ray abnormalities (small irregular opacities and/or pleural changes) of the type known to be induced by asbestos were found in a proportion of those examined. A cross-sectional study of maintenance workers in a large chemical plant was undertaken to evaluate the prevalence of asbestosis; 185 workers were examined. Radiologic evidence of parenchymal interstitial fibrosis was found in 24% of those examined; in 10% of workers, parenchymal fibrosis was the only abnormality. Pleural fibrosis and/or calcification was found in the absence of parenchymal fibrosis in 14% of cases; in another 14% of workers, both parenchymal and pleural abnormalities were detected. The prevalence was significantly higher in those employed 20 or more years. Pleural abnormalities were more prevalent than were parenchymal changes. The increased risk of lung cancer and mesothelioma remains to be studied.

Adult↗
PubMed1979

[Hemodynamic studies during temporary, unilateral occlusion of the pulmonary artery (author's transl)].

During pre-operative evaluation of 35 patients prior to pulmonary resection, pressure measurements in the right heart and pulmonary circulation were performed. In addition to pressure values, pulmonary ventilation and partial pressures of the blood gases were assessed before and during unilateral occlusion of the pulmonary artery at rest and during exercise. Statistically significant increased values from regression analysis were obtained for mean pulmonary artery pressure, right ventricular end-diastolic pressure, pulmonary vascular resistance and right ventricular work. The results show that plethysmorgraphic and ergometric studies as well as their combination with blood gas analysis, are not indicative of changes in right ventricular or pulmonary arterial hemodynamics. Prior to pulmonary resection, catheterization should be performed at rest and during exercise to assess these variables.

Adult↗
PubMed1978

Health status of styrene-polystyrene polymerization workers.

Styrene monomer is a greatly used chemical, chiefly in the production of polystyrene. A cross-sectional health survey of 493 production workers was undertaken at the oldest and largest monomer production, polymerization, and extrusion facility in the United States. Relative exposure durations and levels were obtained from occupational histories and corroborated by spot air sampling, blood and fat styrene concentrations and levels of urinary mandelic and phenylglyoxylic acids. Statistically significant differences between the prevalence of abnormalities in high and low exposure groups were found for the following: history of acute prenarcotic symptoms, history of acute lower respiratory symptoms, peroneal nerve conduction velocities, relative lymphocytosis, and elevated gamma glutamyl transpetsidase. The following showed no distinct pattern in prevalence when analyzed by exposure group: chest radiographic changes; indices or restrictive, obstructive and small airway dysfunction; other hepatic and hematological parameters; carcinoembryonic antigen level; sputum cytopathology; radial nerve conduction velocities; and ophthalmological findings. Clinically significant abnormalities were rare.

Environmental Exposure↗
PubMed1977

[Acute respiratory distress syndrome after near-drowning (author's transl)].

After successful rescue from drowning there may develop a situation which is called secondary drowning, resulting in acute respiratory distress characterized by interstitial pulmonary oedema, hypoxaemia, hypercapnia and acidosis during drowning, direct alteration of the alveolar membrane by aspirated water and particulate matters and a volume overloading by adsorption and--not seldom--inept therapy. This situation requires mechanical ventilation and forced diuresis, combined with high doses of steroids, antibiotics and digitalis. We present the case of an eleven year old patient whose clinical course demonstrate the necessity of exact clinical observation after rescue from drowning. After development of acute respiratory distress only the immediate utilization of the therapeutic modalities of an intensive care may result in a satisfactory outcome. Four months later our patient had normal pulmonary function except for a moderate reduction of compliance.

Anti-Bacterial Agents↗