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Biomedical subjects

S Daniel

Publications and source records attributed to S Daniel.

At least 109 records · Page 6Linked to original sources
PubMed1986

[Acute myopathy and hyperthyroidism].

A 40 year-old woman with a rapidly progressive proximal muscle deficit of all four limbs had an acute myopathy secondary to hyperthyroidism. Biopsy of the quadriceps femoris revealed signs of non specific muscle impairment with type II fiber atrophy. Treatment with methimazole and correction of the thyroid condition led to rapid disappearance of the disorders. Eighteen months later the clinical status was normal and a second quadriceps femoris biopsy showed that the muscle had normalized.

Acute Disease↗
PubMed1984

Two cases of hemorrhagic fever with renal syndrome in northern Greece.

Two cases of hemorrhagic fever with renal syndrome were diagnosed in woodcutters presumably exposed to wild rodents and their urine in a forest in northern Greece. The disease was characterized by acute renal insufficiency without hemorrhagic manifestations. One patient required hemodialysis, but both recovered without sequelae and developed a fourfold increase in titer of antibody to Hantaan virus, as determined by an immunofluorescence test. These are the first reported cases of hemorrhagic fever with renal syndrome in Greece.

Adult↗
PubMed1983

Recovery from a viral respiratory tract infection. IV. Specificity of protection by cytotoxic T lymphocytes.

Immune spleen cells enhanced for influenza-specific cytotoxic activity after exposure to virus-infected stimulator cells in vitro effect recovery when transferred to nude and immunocompetent mice with influenza pneumonia (5). This protective effect correlated with the virus-specific cytotoxic activity of the transferred lymphocytes and is removed by treatment with anti-0 serum and complement. The experiments presented here indicate that spleen cells taken directly from mice undergoing a primary or secondary infection are less protective than immune spleen cells that are restimulated in vitro before transfer. This decreased ability to clear pulmonary virus and effect survival correlated with their relatively lower levels of influenza-specific cytotoxicity. Protection did not correlate with the level of natural killer cell activity of transferred cells. The results also indicate the immune spleen cells that are protective are influenza A subtype cross-reactive and are H-2-restricted; H-2d immune spleen cells effected recovery of H-2d but not H-2k challenged mice.

Animals↗
PubMed1983

Lymphangioma of the mesentery of the jejunum: report of a case and a brief review of the literature.

Lymphangiomas are benign tumors of lymphatic vessels, that are more commonly found in the pediatric age group, and thought to be congenital in nature. They most commonly occur in the region of the neck, but they frequently may be found in the abdominal cavity. In the abdominal cavity, the tumors usually involve the mesentery of the small or large intestines. They are usually asymptomatic but may present with signs and symptoms of intestinal obstruction. The tumors are rare enough to arouse interest whenever a case is encountered. We present a case of lymphangioma of the mesentery of the jejunum in a young adult which clinically mimicked acute appendicitis.

Acute Disease↗
PubMed1982

Platelets in the prediction of thrombotic risk.

A study is reported which tries to identify those members of the general population who may be at increased risk of vascular disease. It is probable that patients who have had previous thrombotic episodes are inherently more at risk of further episodes and that a thrombus many months ago will not affect current tests. Accordingly we carried out a number of tests involving platelets on 'controls', and on patients with a past history of either myocardial infarction or deep vein thrombosis (DVT) and patients suffering from intermittent claudication who also are assumed to be at higher risk than the controls. Differences were demonstrated between controls and patient groups and these differences were utilized to develop statistical functions with the ability to discriminate between the groups. The functions were then tested using a second set of data from similar groups. Those designed to discriminate between myocardial infarction patients and controls and between patients with claudication and controls were validated. The heparin thrombin clotting time was found to be the prime predictor variable; the platelet count, platelet volume, platelet factor 3 clotting time and the bleeding time have some predictive value. The antithrombin clotting time, platelet aggregation and platelet adhesiveness tests as measured were not found to have discriminating potential. It is suggested that these appropriate risk functions could be of practical value in identifying members of the general population who may be at greater risk than average. The discriminate functions for DVT patients and controls could not be validated, suggesting differences in platelet involvement in arterial and venous thrombosis.

Analysis of Variance↗
PubMed1979

Cytotoxic T-cell and antibody responses to influenza infection of mice.

The immune response to influenza infection was evaluated in mice using recently developed techniques to measure the induction of cytotoxic thymus-derived (T) lymphocytes and complement-dependent cytolytic antibody, locally and systemically, during primary and secondary immunization. Cytolytic antibody responses were compared to antibody titres measured by haemagglutination-inhibition (HI) and neutralization in the same samples. The development of these responses was also correlated with the titres of virus in the lung, in an attempt to further define the role of these host immune responses which can kill virus infected cells during recovery from influenza infection in vivo.

Animals↗
PubMed1978

Differential plus polarographic determination of submicrogram quantities of carmustine and related compounds in biological samples.

A polarographic method was developed to determine the antineoplastic agent carmustine and other nitrosoureas, such as N-methyl-N-nitrosourea and N-cyclohexyl-N-nitrosourea, in biological fluids at levels well below 1 microgram/ml or g. The stability of carmustine in different media was investigated to prevent losses during administration or assay. Examples of nitrosourea determination in biological samples are given.

Animals↗
PubMed1978

Host defense mechanisms against influenza virus: interaction of influenza virus with murine macrophages in vitro.

The interaction of mouse macrophages with influenza virus was examined as part of a study into the defense mechanisms against influenza infection. Macrophages exposed to A/Port Chalmers/1/73 virus produced infectious foci on susceptible indicator cell monolayers. Sampling of supernatant fluids and cells from infected macrophage cultures showed release of virus adsorbed to the cell surface. Active virus replication in macrophages could not be demonstrated. Exposing macrophages to specific antibody before or after virus infection resulted in a significant decrease in the number of infectious macrophages. The results suggest that although macrophages are not the source of replicating influenza virus, they are able to spread the infection by having virus attaching to their surface. This activity is interfered with by the presence of specific antibody.

Animals↗