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Biomedical subjects

S D Voropaeva

Publications and source records attributed to S D Voropaeva.

At least 19 recordsLinked to original sources
PubMed1996

[Obligate anaerobic microbes in obstetric and gynecologic diseases].

The paper reviews recent-years' papers and the data of their own investigations on a role of obligate anaerobic microbes in obstetric and gynecological abnormality. The fact that secondary pelvic inflammatory processes caused chiefly by non spore-forming anaerobes is ascertained. There is evidence that obligate anaerobic bacteria are involved in the abnormality directly unassociated with the development of an inflammatory process: preterm labor, premature discharge of amniotic fluid, intranatal fetal hypoxia, respiratory distress syndrome and hyaline membrane disease of the premature newborn. Among vaginal infections the key role is played by bacterial vaginosis which is, from the pathophysiological point of view, now a severe derangement of the vaginal environment system with greatly prevalent obligate anaerobic bacteria and without lactoflora. Complications associated with this abnormality are noted.

Bacteria, Anaerobic↗
PubMed1995

[The transplacental passage and distribution of ceftazidime in the fetal and maternal organs in a 2nd-trimester abortion].

Transplacental passage of ceftazidime was studied in 17 women with second-trimester pregnancy which had to be discontinued for medical causes. A single intramuscular injection of the antibiotic resulted in creation of therapeutically active concentrations in fetal blood and organs, amniotic fluid, and placenta. Transplacental passage of ceftazidime from the mother to the fetus was 19.12%, diffusions to the amniotic fluid 14.46%, diffusion to the placenta 48.46%. Ceftazidime may be effective for the prevention and therapy of fetal intrauterine infection and chorioamnionitis.

Abortion, Therapeutic↗
PubMed1993

[An animal experiment on transplacental transport of ceftazidime at various terms of pregnancy].

The experiments on rats revealed good transplacental transfer of ceftazidime to the fetus. The level of the transfer increased with increasing of the pregnancy term. The antibiotic concentration in the fetal tissues exceeded the MIC for opportunistic organisms. The ceftazidime concentrations in the amniotic fluid were equal to the therapeutic ones at the early and late terms of the pregnancy. At the early terms of the pregnancy the antibiotic transferred to the amniotic fluid transplacentally. The data are in favour of recommending ceftazidime for prophylaxis and treatment of fetal intrauterine infections.

Amniotic Fluid↗
PubMed1990

[The formation of the normal intestinal microbiocenosis in newborn infants and under antibiotic therapy].

The dynamic study of the microecological state of the intestine in 41 newborns up to the age of 3 months has been made by biochemical and bacteriological investigation methods. The results of the biochemical rapid analysis have been found to be in complete agreement with those of the bacteriological analysis and, besides, to provide essential additional data. The biochemical rapid analysis permits the evaluation of the state resistance to the colonization of the intestine in children, starting from the age of 6 days. The presence of beta-alanine and ninhydrin-positive unidentified Nos. 7, 8a-1, 8d, 9, 10, 11 and 21 is indicative of a greater decrease in the level of the colonization of the digestive tract.

Anti-Bacterial Agents↗
PubMed1989

[The role of nonsporulating anaerobic bacteria in the etiology of postabortion and postpartal endometritis].

As the result of the study carried out by the authors, a conclusion has been made on the leading role of polymicrobial aerobic-anaerobic complexes, capable of producing a synergic effect, in the etiology of endometritis, anaerobic microorganisms prevailing in their importance. In the etiology of endometritis the most important organisms are bacteroids and peptostreptococci among anaerobes, enterobacteria and group D streptococci among aerobes. Anaerobic bacteria causing endometritis are most sensitive to dalacin and lincomycin, least sensitive to benzylpenicillin, resistant to aminoglycosides. The amounts of aerobic and anaerobic microflora contaminating the uterine cavity correlate with the severity of endometritis.

Abortion, Spontaneous↗
PubMed1987

[Etiological structure and antibiotic sensitivity of the causative agents of puerperal endometritis].

The study revealed the dominating role of aerobic-anaerobic microbial associations and in particular the specific role of anaerobic gram positive cocci in development of puerperal endometritis. The data suggested that a definite level of the uterus cavity contamination with microbes, not lower than 10(4)-10(5) CFU/ml or a large number of bacterial associates, not less than 3 was necessary for endometritis development. It was confirmed that pathogenicity of anaerobes increased in the presence of aerobic bacteria. It is concluded that quantitative methods for detecting the main causative agents of endometritis are needed. A set of antibacterial drugs for rational antibacterial therapy of puerperal endometritis is recommended.

Anti-Bacterial Agents↗
PubMed1985

[Pharmacokinetics of cefuroxime in pregnant women with acute pyelonephritis].

The pharmacokinetics of cefuroxime was studied in 40 pregnant women with acute pyelonephritis. The women were in the 2nd and 3rd terms of pregnancy. The antibiotic was injected in a dose of 500 mg. The antibiotic levels in the blood and urine were determined with the agar diffusion method. The pharmacokinetic parameters were measured in a one-compartmental model with regard to antibiotic absorption. The measurement was performed with the use of computer. The cefuroxime concentrations in the blood and urine were practically the same at all periods of the study and at different terms of pregnancy. In pregnant women with acute pyelonephritis, the volume of cefuroxime distribution and the time of a two-fold decrease in the blood antibiotic levels increased. The estimation of the optimal scheme of cefuroxime dosing by the Krueger-Timer principles provided treatment of acute pyelonephritis in pregnant women with intramuscular injections of the antibiotic in a dose of 500 mg every 8 hours for 7-8 days.

Acute Disease↗
PubMed1984

[Antibacterial therapy of pyelonephritis in pregnant women].

To determine the optimal schemes of rational antibacterial therapy of pyelonephritis gravidarum with ampicillin and cephuroxim, assays of the patient urine and studies on the pharmacokinetics of the drugs were performed. The bacteriurea levels were estimated in 264 women with Gould's method in modification of Ryabinsky and Rodoman. The causative agents of the disease were isolated from the urine of 92 pregnant women. Sensitivity of the isolates to 9 antibiotics was tested with the use of standard paper disks and the method of serial dilutions in solid media. The pharmacokinetics of ampicillin and cephuroxim in the blood and urine of 97 patients was studied for 6-8 hours after parenteral administration of the antibiotics in doses of 500 mg. Comparative analysis of the pharmacokinetic parameters of the antibiotics in the blood and urine of the patients, the antibiotic MICs for the disease causative agents and the clinical course of the disease suggests that pyelonephritis gravidarum should be treated with ampicillin and cephuroxim on doses of 500 mg injected intramuscularly 4 and 3 times a day respectively for 7-8 days in combination with antiinflammatory therapy.

Ampicillin↗
PubMed1984

[Distribution of antibiotic-resistant microorganisms among newborn infants in an intensive care unit].

Bacteriological assay of the nasal, fauces and feces microflora of 40 newborns of the Department of Intensive Therapy revealed their primary colonization with various opportunistic microorganisms from the environment. Sensitivity of the isolates to 15 antibiotics was tested. It was shown that multiple resistance strains predominated. The staphylococcal strains were mainly resistant to benzylpenicillin, ampicillin, erythromycin and polymyxin. The enterococci were most frequently resistant to methicillin, lincomycin, kanamycin, monomycin and neomycin. Tetracycline and chloramphenicol resistant strains of E. coli were detected. Marked resistance to carbenicillin, ampicillin, cephuroxim and cephaloridin and high sensitivity to cephotaxim and gentamicin were determined in the Klebsiella strains with the method of serial dilutions on solid media. The presence of opportunistic microorganisms with multiple resistance to antibiotics, ate appearance of the own microflora and decreased immunological defence may be the cause of infection in newborns of departments of intensive therapy. Circulation of antibiotic-resistant strains in departments for newborns is fraught with a threat of hospital infections.

Anti-Bacterial Agents↗
PubMed1983

[Comparative clinical efficacy of cephotaxim and cefuroxime against the pathogens of inflammation in obstetrics and gynecology].

The use of cephotaxim in the treatment of obstetric and gynecological patients with various infectious complications, as well as in the treatment of newborn infants in the Department of Intensive Therapy showed it to be highly effective in 100 per cent of the cases. The adverse reactions of cephotaxim were observed in 1 out of 43 patients. It should be noted that cephotaxim did not inhibit the host anaerobic indigenous flora. No cases of dysbacteriosis were recorded. Comparative analysis of the data on determination of the MIC of cephotaxim and cephuroxim with respect to various species of opportunistic microorganisms demonstrated that cephuroxim was more active against Staph. aureus, while cephotaxim against Klebsiella. Cephotaxim displayed activity against part of the strains of Ps. aeruginosa and streptococci of group D, which was not common to cephalosporins of the previous generations.

Bacterial Infections↗