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Biomedical subjects

S D Vincent

Publications and source records attributed to S D Vincent.

At least 19 recordsLinked to original sources
PubMed1992

Oral candidosis. Clinical, historical, and therapeutic features of 100 cases.

Oral candidosis is an increasingly important disease that affects a significant percentage of the population. Traditionally known as an opportunistic pathogen, the broader clinical scope of oropharyngeal candidal infections is now being recognized. The clinical and historical features of 100 patients referred for diagnosis and management of candidosis have been reviewed. The age, gender, chief complaint, medical history, medications, and clinical findings have been noted. A wide range of clinical signs and symptoms, and the rationale behind the topical and systemic antifungal therapies provided to this patient population, are discussed.

Administration, Oral↗
PubMed1992

Clinical, historic, and therapeutic features of aphthous stomatitis. Literature review and open clinical trial employing steroids.

The clinical and historic features of 50 patients with diagnosed aphthous stomatitis and treated with topical triamcinolone acetonide, 0.1% or 0.2% aqueous suspension; alone or in combination with initial burst therapy of 40 to 60 mg of prednisone, are reviewed. The mean age of our patients was 36.6 years (range 6 to 80 years). The duration of the chief complaint, usually oral pain, or more specifically, recurrent oral ulcers, was 11.1 years (range 4 weeks to 40 years). All patients showed a wide range of ulcer sizes when examined initially or at follow-up. Forty were followed up for an average of 22.9 months. Thirty-four reported prompt healing of ulcers identified at the time of initial evaluation, and no or markedly fewer ulcers subsequently if maintenance therapy of prophylactic topical triamcinolone, 0.1% or 0.2% aqueous rinse, was used. Five patients reported partial relief. No systemic side effects were noted even after long-term topical therapy. Local candidosis was a complication encountered in five patients.

Administration, Oral↗
PubMed1992

Diagnosis and management of autoimmune and idiopathic mucosal diseases.

Several autoimmune and idiopathic diseases directly affect the oral mucosa. Current therapeutic management is aimed primarily at the control and prevention of symptoms. It is important for patients to understand the goals of therapeutic management because these diseases often are characterized by periods of remission and exacerbation that require long-term follow-up.

Autoimmune Diseases↗
PubMed1991

Diagnosing and managing oral lichen planus.

Lichen planus is a chronic and recurrent inflammatory disease characterized by unpredictable exacerbations and remissions. It affects the skin and/or mucous membrane in nearly 2 percent of the adult population. The symptoms are transient, but clinical evidence of oral disease is more persistent.

Anti-Inflammatory Agents↗
PubMed1990

Oral lichen planus: the clinical, historical, and therapeutic features of 100 cases.

Lichen planus is a chronic inflammatory epidermal and mucosal disease, the cause of which is poorly understood. We reviewed the clinical and historic features of 100 patients referred to our clinic for diagnosis and management of lichen planus. The age, gender, chief complaint, duration of the chief complaint, medical history, medications, and clinical findings were recorded. Past therapeutic modalities were reviewed. Of therapeutic significance, 25 patients with oral lichen planus had a secondary oral candidiasis. Management of symptomatic lichen planus with topical and systemic steroid is discussed. The pharmacology of topical and systemic steroid usage and the rationale for treatment are discussed.

Administration, Topical↗
PubMed1989

Adenocarcinoma arising in a thyroglossal duct cyst: report of a case and literature review.

A case of thyroglossal duct cyst carcinoma is presented, and the previously reported cases are reviewed. The clinical features of these midline neck masses do not suggest the presence of a carcinoma which may be localized to a single area of the cyst wall. Therefore, submission of the complete surgical specimen for histologic examination is recommended even if frozen sections during surgery fail to reveal a carcinoma.

Adenocarcinoma↗
PubMed1988

Incidence and characterization of temporomandibular joint sounds in adults.

The findings from this study indicate that some signs and symptoms associated with TM dysfunction are relatively common clinical observations in adults, and that they might or might not be associated with pain, decreased joint mobility, and most importantly, might not be progressive. The rationale for instituting therapy in patients with TM noises who are asymptomatic and have freedom of mandibular movements needs to be evaluated in relation to these findings.

Adolescent↗
PubMed1987

Central granular cell odontogenic fibroma.

First described in 1962, the so-called granular cell ameloblastic fibroma has been a rarely reported benign odontogenic tumor. On reviewing the literature, we have identified eight previously reported cases. All cases involved well-circumscribed radiolucencies in women who ranged in age from 53 to 65 years. Seven lesions occurred in the posterior body of the mandible, and one occurred in the premolar region of the maxilla. All lesions were treated with surgical excision, and no recurrences were identified during follow-up periods of 6 to 144 months. Two additional cases also appear to represent instances of this neoplasm, which bring the total number identified to ten. We describe the clinical, radiographic, and histopathologic features of two additional cases and suggest reasons the tumor should be referred to as central odontogenic fibroma, granular cell variant.

Adult↗
PubMed1987

Nodular hidradenoma: an eccrine sweat gland analog of pleomorphic adenomas of salivary gland origin.

A tumor of eccrine sweat gland origin is described that bears a striking resemblance to pleomorphic adenomas of salivary gland. Upon closer examination, the tumor contained areas of apocrine decapitation secretory activity, primitive hair follicles, and melanin pigmentation, indicating cutaneous rather than mucosal origin. Six-month follow-up examination has revealed no evidence of recurrence.

Adenoma, Pleomorphic↗
PubMed1986

Carcinoma cells may modulate their supporting connective tissue.

The patterns of growth of two chemically-induced murine squamous cell carcinoma cell lines and their effect on a deep connective tissue graft bed were examined in syngeneic C57Bl/6 mice. The two cell lines displayed markedly different patterns of histo-differentiation but in vivo the poorly-differentiated line (FS) gave rise to tumours with much lower inocula than the well-differentiated cell line (A5). To evaluate the effect of the tumour cells on the graft bed a bioassay involving transplantation of epidermal sheets was used. Whereas the pretreatment of the deep connective tissue graft bed with the FS cell line facilitated the subsequent growth of the epidermal sheets, beds treated with the A5 cell line, lethally irradiated tumour cells or receiving no treatment failed to support continued growth of normal epidermis. We suggest that this ability of a carcinoma cell line to modify the connective tissue may facilitate the establishment of metastatic deposits.

Animals↗