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Biomedical subjects

S D Rose

Publications and source records attributed to S D Rose.

46 records · Page 3Linked to original sources
PubMed1978

Osmium-labeled polynucleotides: reaction of osmium tetraoxide, with poly-1,N6-ethenoadenylic acid.

Osmium tetraoxide, in the presence of ligands such as pyridine and bipyridine, adds across the etheno bridge of 1,N6-etheno-9-methyladenine and poly-1,N6-ethenoadenylic acid. The Os:P ratio in the labeled polynucleotide was approximately equal to 1 when bipyridine was used as the stabilizing ligand. A similar study with polycytidylic acid, which had been partially modified with chloroacetaldehyde so that some bases were converted to 3,N4-ethenocytosine, gave an OS:P ratio of approximately equal to 1.3. Calf-thymus DNA, in which the adenine and cytosine bases were modified by chloroacetaldehyde, gave an Os:P ratio of approximately equal to 1 after 24 h. These results suggest that 3,N4-ethenocytosine will add two Os labels.

Adenosine Triphosphate↗
PubMed1977

Interpersonal skill training with institutionalized elderly patients.

A behavioral program to train elderly nursing home patients in interpersonal skills was systematically developed and evaluated. Data obtained from intensive interviews with patients, staff, and professionals were used to construct a training program and self-report and behavioral measures for assessing the program's effectiveness. Twenty-five patients were randomly assigned to the training program or to one of two control condotions. On a behavioral measure of responses to situations that had been included in training, the Skill Training program was superior to the control conditions. However, learning failed to generalize to novel situations. Directions for future skill training research are discussed.

Aged↗