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Biomedical subjects

S D Roberts

Publications and source records attributed to S D Roberts.

At least 55 records · Page 3Linked to original sources

Health care costs of medical patients at an urban care center.

Many cost containment strategies advocate that physicians should use fewer or less costly resources. In order to place these strategies in perspective, components of charges (costs) for medical patients at an urban center were examined to ascertain their contribution to the total health care bill. Contributions to total costs by location of service were: inpatient, 77.9%; outpatient, 17.1%; emergency room, 5.0%. Contributions by cost category were: facility charge, 52.8%; tests, 25.6%; pharmaceuticals, 11.0%. A goal to reduce total costs by 5% would require reducing pharmaceuticals by 45.4% or tests by 19.5%. In contrast, the same goal could be accomplished by reducing hospitalization by only 6.4%. If a strategy increased ambulatory costs by 5%, but resulted in a 7.5% decrease in hospitalization, the total health care costs would still decrease by 5%. Thus, rather than using fewer and less costly resources, physicians are encouraged to use more resources in ambulatory care to prevent morbidity requiring hospitalization.

Academic Medical Centers↗

Immunization to prevent insulin-dependent diabetes mellitus? The economics of genetic screening and vaccination for diabetes.

There is increasing evidence that some cases of insulin-dependent diabetes mellitus are virally induced, and vaccination against this disease may become possible. We have prospectively examined the costs and benefits that would occur if a diabetes vaccine were developed, using a decision tree to model the alternative vaccination policies, including histocompatibility leukocyte antigen (HLA) screening. We found many cost and likelihood data in the literature, and when data on the potential vaccine had to be hypothesized, we used sensitivity analysis to check our estimates. We conclude that vaccinating all children at age 3 would be preferable to HLA screening and vaccinating only persons with a genetic predisposition to developing diabetes. A 50% effective vaccine would cut the diabetes incidence rate by 29% and save the U.S. population $30 million annually in direct costs of diabetes care. If indirect costs are considered these savings could amount to $4.2 billion over 60 years, discounted to present value at 5%, while preventing over 200,000 cases of insulin-dependent diabetes.

Adolescent↗

Are home hemodialysis aides cost-effective? Cost of home hemodialysis aides.

Payment for home hemodialysis aides has been proposed as a means of inducing shifts from center hemodialysis to less-expensive home hemodialysis. By using a simulation model, we computed the cost per life year of end-stage renal disease care when changes in the proportions of patients treated by center for home hemodialysis are brought about by paying for home hemodialysis aides. If all home hemodialysis patients receive payment for aides, total costs will increase unless there are sufficient shifts from center to home hemodialysis to offset the increased costs. The cost-effectiveness of home hemodialysis aides is critically dependent on who receives a paid aide, the salary of the aid, and the number of patients who move from center to home hemodialysis. Poorly formulated regulations may jeopardize the cost-effectiveness of home hemodialysis and increase the total cost of end-stage renal disease care.

Allied Health Personnel↗

High frequency Bekesy audiometry: II. Threshold test procedure, reliability and validity.

Normal-hearing Ss (N: 20) produced 2 sets of Bekesy threshold tracings, from 2-8 kc/s, on a conventional Grason-Stadler E-800 audiometer, and from 2-20 kc/s on a unit (HF E-800) modified for high frequencies. Half the Ss then produced at least 2 sets of tracings each in the fixed-frequency mode on the HF E-800. The pulsed-tone fixed-frequency procedure is recommended for HF HTLs. Maximum mean test-retest HTL differences of 1-4 db were obtained. Reliability r's obtained from the HF E-800 were equivalent to or surpassed those from the E-800; a very high proportion of such coefficients was statistically significant. Reduced validity coefficients, calculated at the frequencies common to the units, were attributed at least in part to differences in methods of coupling the transducers to the ear. It was concluded that the HF E-800 unit in the fixed-frequency mode could be used with some confidence to assess HF HTLs.

Adult↗

Cost-effective care of end-stage renal disease: a billion dollar question.

We examined the survival time and costs of therapy for patients with end-stage renal disease. A computer simulation model of the current system was constructed to estimate the cost-effectiveness of home and center hemodialysis and live related as well as cadaver donor renal transplantation. Analysis of the simulation showed that live related donor transplantation was the least costly and had the greatest survival time, while center hemodialysis had the poorest cost-effectiveness. By simulating changes to the present system of care, we found that shifts from center dialysis to either home dialysis or cadaver donor transplantation would save $7000 to $8000 per life year, or $284 million per year for the existing end-stage renal disease population. However, if legislative changes fail to produce real shifts from center hemodialysis, costs will increase. We conclude that the substantial costs for end-stage renal disease can be contained by shifting from the widespread use of center hemodialysis.

Cadaver↗

Measles virus-specific antibodies and immunoglobulin M antiglobulin in sera from multiple sclerosis and rheumatoid arthritis patients.

When rheumatoid factor in rheumatoid arthritis and multiple sclerosis sera was titrated by the fluorescent antibody method on measles virus-infected cells, there was a marked and variable drop in titer on acetone-fixed cells as compared with unfixed cells. This was accounted for by the failure of measles virus hemolysin-inhibiting (HLI) antibody of the immunoglobulin G class to bind to acetone-fixed infected cells. It was shown by staining unfixed and acetone-fixed measles virus-infected cells that rheumatoid factor in most rheumatoid arthritis sera combined with measles virus-specific hemagglutinin-inhibiting and HLI antibodies, whereas rheumatoid factor in multiple sclerosis sera combined only with HLI antibody. Rheumatoid factor of similar specificity was also observed in normal sera and occasionally in rheumatoid arthritis sera. Both rheumatoid arthritis and multiple sclerosis sera showed almost identical increases in average titer above normal of measles virus-specific fluorescent staining immunoglobulin G and HLI antibodies.

Adult↗

Arthritis.

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Arthritis, Rheumatoid↗

Cost effectiveness in the detection of renal artery stenosis.

Cost effectivenesses of four tests for diagnosing renal artery stenosis were examined. Sensitivity, specificity, cost per patient, and cost per stenosis found for a variety of diagnostic strategies using these tests were retrospectively evaluated using clinical data from 605 hypertensive patients. Cost effectiveness of a given strategy was found to depend on the sequence in which the tests were performed, but to be relatively independent of the exact cost of the tests. Auscultation for a systolic/diastolic abdominal bruit was the most cost-effective test for beginning a diagnostic strategy and showed a 99.6% specificity for stenosis. When the patient has a systolic bruit only or no bruit, plasma renin activity measurement should guide the clinician's choice of whether to test further with intravenous pyelography or renal arteriography. Diagnosis of renal artery stenosis using these tests is estimated to cost between $2,300 and $6,200 per stenosis found, depending on the prevalence of renal artery stenosis.

Adult↗

Surgery or angioplasty for cost-effective renal revascularization?

The authors retrospectively compared the cost-effectiveness of percutaneous transluminal angioplasty with that of renal artery bypass surgery for treating renal artery stenosis, using the experiences of 52 patients treated for renovascular hypertension between 1977 and 1983. The expected results of treatment for angioplasty and surgery were taken from published literature and from experience. Based on the analysis, angioplasty is recommended for treating patients with fibromuscular disease, and patients less than 50 years old, while surgery is the preferred treatment for older patients and those with atherosclerotic disease. These strategies not only minimize the cost per life-year gained from treatment, but also maximize the life expectancy of treated patients. The results are quite robust for the discount rate used in the cost calculations, for variations in the expected rate of stenosis recurrence, and for variations in the treatment outcome probabilities.

Age Factors↗