Search PubMed⌕ Search

Biomedical subjects

S D Podymova

Publications and source records attributed to S D Podymova.

At least 19 recordsLinked to original sources
PubMed1998

[Hepatomegaly ].

Explore the source record for details and available documents.

Diagnosis, Differential↗
PubMed1998

[Clinical trial of heptral in patients with chronic diffuse liver disease with intrahepatic cholestasis syndrome].

Heptral (S-adenosine-L-methionine) was given to 32 patients with chronic diffuse diseases of the liver and intrahepatic cholestasis. 16 of them had primary biliary cirrhosis (PBC). Phase I of the treatment lasted 16 days when the drug was injected intravenously in a dose 800 mg/day. It was followed by phase 2--1600 mg/day taken for 16 days. A response was registered in the majority of patients. They had relieved symptoms of asthenia, skin pruritus, jaundice. The patients with liver cirrhosis and chronic hepatitis exhibited a statistically significant fall in ALT, AST and GGTP. PBS patients showed insignificant lowering of cholesterol, bilirubin. No resistance was noted in repeated courses. Heptral tolerance was satisfactory.

Adolescent↗
PubMed1997

[Ascites].

Explore the source record for details and available documents.

Ascites↗
PubMed1995

[The treatment of hepatic encephalopathy with Hepa-Mertz].

A course of hepamerz treatment (7 intravenous drip infusions followed by oral administration for 14 days) was tried in 14 patients with hepatic cirrhosis to clarify hepamerz effects on hepatic encephalopathy and hyperammonemia which were judged by blood ammonium levels and time of psychomotor tests. All the patients responded. Fasting ammonium levels reduced in 67%, after meal in 82% of patients, 68% improved their psychomotor parameters. Transient nausea as a side effect occurred in 3 patients.

Ammonia↗
PubMed1994

[Clinical and prognostic significance of cellular immunity factors in patients with chronic liver diseases].

The paper presents the results of comprehensive studies of quantitative and functional parameters of cellular immunity in 283 patients with chronic liver diseases, using various rosette tests and monoclonal antibody phenotyping of immunocompetent cells. The pattern of changes in blood immunocompetent cells and immunoglobulins allows prediction of the natural history of chronic active hepatitis and hepatic cirrhosis of viral and alcoholic origin. The data on autorosette-forming and hepatic-specific lipoprotein-sensitive rosette-forming cells were found to be the most informative. As compared to health, there were substantial changes in the subpopulation composition of immunocompetent cells and immunoglobulins in hepatic cirrhosis. The changes in immunoregulatory theophylline-resistant (OKT4+, OKT8+, T mu and T gamma) and theophylline-sensitive E-rosetting, as well as effector (ICO11+ and ICOHM1+) cells were the leading immunopathogenetic link of hepatic cirrhosis. In the latter, the subpopulation composition of immunocompetent cells depended on the activity of a pathological process, the state of compensation, as well as the levels of HBsAg and blood anti-delta-antibodies. The subpopulation analysis of immunocompetent cells enabled the author to outline the specific features of the immune status of etiological types, as well as predictive types of chronic active hepatitis and hepatic cirrhosis, which may serve as evidence for goal-oriented immunomodulating therapy.

Adolescent↗
PubMed1993

[Autoimmune liver diseases: the relation to other autoimmune pathology].

The paper reviews literature on association of primary biliary cirrhosis and autoimmune chronic active hepatitis with other autoimmune diseases. Included are the data on statistics of a number of diseases with histological findings and autoantibodies detection. A basic role of immunological tolerance infringement in pathogenesis of systemic involvement in autoimmune liver diseases is emphasized. Mechanisms leading to development of systemic autoimmune processes are considered.

Antibody Formation↗
PubMed1991

[Congenital hypoplasia of the pancreas with lipomatosis and bone marrow dysfunction (Shwachman syndrome)].

The description is given of Shwachman syndrome in a male of 17, with a long anamnesis of malabsorption syndrome, granulocytopenia, repeated bronchopneumonia, somatogenic subnanism and hypogonadism. The death resulted from acute cardiovascular insufficiency. Post-mortem examination revealed exocrine pancreas hypoplasia with lipomatosis, Wirsung duct atresia, fibrocholangiocytosis and fat hepatosis, visceral anemia, delay in the maturation of granulocytes in the bone marrow, somatogenic polyglandular endocrinopathy, metabolic myocardium necrosis, calcinosis of the small arteries wall, lymphoid tissue atrophy, focal pneumonia of the upper lobe of the left lung.

Adolescent↗
PubMed1991

[Problem of chronic hepatitis (classification, pathogenesis and treatment].

Update information is added to classification of chronic hepatitis. A new form--chronic lobular hepatitis is described as well as characteristic features of immune response to hepatitis B virus (HBV). The findings enable the authors not only to relate autoimmune abnormalities to HBV infection, but to consider them an essential component of this infection. The leading role in pathogenesis of viral hepatic lesions is played by cellular immunity. A sound subpopulation analysis of immunocompetent blood cells was carried out for chronic active hepatitis and hepatic cirrhosis in correlation with HBsAg. It is emphasized that a biological cycle of HBV development determines the type and power of the macroorganism immune response and should be allowed for when designing policy of treatment of chronic hepatic viral diseases. Criteria are proposed for deciding on immunomodulators and immunodepressants for chronic viral and autoimmune hepatitis.

Autoimmune Diseases↗
PubMed1991

[Fibrinolysis as a cause of coagulopathy in patients with chronic diffuse diseases of the liver].

Examination was performed of 74 patients with chronic diffuse diseases of the liver; chronic active hepatitis, compensated hepatitis, decompensated cirrhosis of the liver (26, 28, 20 patients, respectively). Fibrinolysis was evaluated in relation to its effect on hemocoagulation. It appeared the principal cause of coagulopathy in 3% of the examinees. It is stated that activated fibrinolysis in chronic diffuse diseases of the liver underlies coagulopathy in few patients with decompensated cirrhosis, in compensated hepatopathy the influence of fibrinolysis on overall coagulative capacity of peripheral blood is insignificant.

Adult↗
PubMed1990

[The mechanisms of disorders in the hemostatic system of patients with chronic diffuse liver diseases].

A total of 70 patients with chronic hepatitis and 60 with liver cirrhosis (LC) were examined. The hemorrhagic syndrome (HS) was identified in 16% of patients with chronic active hepatitis, in 26% with compensated and in 76% with decompensated LC. Intravital study of intravascular blood coagulation and liver microcirculation with the aid of fibrin determination according to D. D. Zerbino made it possible to establish local intravascular coagulation (LIC-syndrome). Study into the hemostatic and fibrinolytic systems, analysis of liver function, hemocoagulation and the intensity of the LIC-syndrome permitted one to arrive at conclusions about complex impairments of the hemostatic system in patients with chronic diffuse liver diseases characterized by a tendency towards blood hypocoagulation in the systemic blood flow with the risk of the development of the HS and a tendency towards hypercoagulation (with the risk of thrombosis development) in the vascular bed of the liver. It has been shown that the main cause of the HS occurring in chronic diffuse liver diseases lies in derangements of the thrombocytic component of the hemostatic system: thrombocytopenia as a consequence of hypersplenism and consumption of the most active thrombocytes in the process of the LIC. Activated fibrinolysis starts to exert an inhibitory action on hemocoagulation in patients with chronic diffuse liver diseases in the stage of decompensated LC. In compensated hepatopathies, the influence of fibrinolysis on coagulation and the development of the HS was immaterial.

Blood Coagulation Disorders↗
PubMed1989

[Prevention and treatment of hemostatic disorders in patients with liver cirrhosis].

Disorders of the different links of the hemostatic system in patients with liver cirrhosis can be corrected by simultaneous prescription of minimal doses of heparin, vicasol and curantyl. As a result, treatment of liver cirrhosis, including cases with initial manifestations of the hemorrhagic syndrome, produced significant improvement of the hemostatic parameters and abatement of this syndrome. It is expedient to include this method in the combined treatment of this category of patients.

Blood Coagulation Disorders↗