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Biomedical subjects

S D Li

Publications and source records attributed to S D Li.

22 records · Page 2Linked to original sources
PubMed1985

Evidence for the role of fibronectin in amphibian gastrulation.

In amphibian embryos, fibronectin (FN) assembles as a fibrillar network on the roof of the blastocoel cavity, preceding mesodermal cell migration. Local inversion of the ectoderm to produce a site where no FN is available prevents mesodermal cell migration. Microinjection of monovalent antibodies to FN arrests gastrulation. A complete inhibition of mesodermal cell migration is obtained after microinjection of a synthetic peptide containing the cell binding site sequence of FN. Prevention of interactions between receptors and FN appears to be the primary cause for blockage of gastrulation.

Ambystoma mexicanum↗
PubMed1982

Malignant transformation of baby hamster lung fibroblasts induced in vitro by a new nitrosamine compound.

A new nitrosamine compound, N-1-methylacetonyl-N-3-methylbutyl-nitrosamine (MAMB-NA), isolated from corn bread inoculated with moulds commonly occurring in Linxian County, a high incidence area for esophageal cancer in North China was tested for its potential carcinogenicity in vitro. Baby hamster lung fibroblasts (BHL) were treated with MAMBNA in tissue culture medium containing liver microsome preparation of Aroclor 1254 treated rat. Cell transformation was assessed by morphological changes, loss of density-dependent inhibition and unlimited growth in vitro, chromosome changes, colony formation on soft agar, growth at low serum concentration, Con A agglutinability and tumor formation after heterotransplantation into immunosuppressed newborn rats. Like the known carcinogens N-methyl-N'-nitro-N-nitroso-guanidine and diethylnitrosamine, MAMBNA was able to cause malignant transformation of cells cultured in vitro.

Animals↗