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Biomedical subjects

S Czekalski

Publications and source records attributed to S Czekalski.

149 records · Page 9Linked to original sources
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[Comparison of the effect of short-term treatment with nifedipine and verapamil on blood pressure, plasma atrial natriuretic peptide (ANP) and cyclic guanosine monophosphate (cGMP) in patients with primary arterial hypertension I degree according to WHO].

The aim of the study was the comparison of the effect of seven day treatment with nifedipine (2 x 10 mg daily) and subsequently with verapamil (3 x 40 mg daily) on blood pressure, heart rate, plasma ANP, cGMP, renin activity (PRA), aldosterone (ALDO) concentrations in patients with primary hypertension. The material consisted of 12 untreated patients with primary arterial hypertension Io WHO. These results suggest that short-term treatment with nifedipine and subsequently with verapamil in patients with primary hypertension Io WHO not influence on plasma ANP, cGMP, PRA and ALDO in spite of blood pressure reduction and the changes in heart rate. It seems that ANP did not participate in hypotensive action of nifedipine and verapamil. No augmentation of urinary sodium excretion was found after short-term treatment with nifedipine or verapamil.

Adult↗
PubMedDate not supplied

[Individual choice of treatment in patients with progressive infiltrative ophthalmopathy in Graves-Basedow disease].

The results of different methods of treatment of infiltrative endocrine ophthalmopathy in 68 patients (52 women and 16 men) aged 28-63 years were evaluated. The analysis of the results indicates that combined treatment with glucocorticoids and tele-cobalt therapy may be considered as the method of choice. In patients with rapidly progressive ophthalmopathy and in patients with inactive peptic ulcer intravenous pulsed glucocorticoid administration may be used instead of oral treatment. When contraindications to corticotherapy exist, good results of treatment may be achieved with tele-cobalt therapy alone. Plasmapheresis seems less effective but may be used in rapidly progressive, short term lasting ophthalmopathy in patients refusing tele-cobalt therapy, in connection with glucocorticoids or after unsuccessful glucocorticoid therapy alone. The consecutive treatment with glucocorticoids and tele-cobalt therapy is effective but requires much more time.

Adult↗