Multiple molecular forms of cytoplasmic glycerol-3-phosphate dehydrogenase in rat liver.
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Biomedical subjects
Publications and source records attributed to S Curry.
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This article explores the effect that the intensive care unit has on patients' families and examines ways for nurses to identify and cope with family needs and stresses in the intensive care environment.
Seven male inpatients suffering from acute schizophrenia were treated with chlorpromazine elixir 100mg 8-hourly for 9 weeks. Nortriptyline 50mg 8-hourly was added during weeks 4, 5 and 6. Plasma chlorpromazine concentrations, antipyrine plasma half-life, blood pressure, pulse rate, pupil size, salivation, handwriting and clinical state were measured at weekly intervals. Plasma chlorpromazine concentrations rose when nortriptyline was added, and the antipyrine plasma half-life was prolonged. Blood pressure dropped on institution of chlorpromazine and dropped further with the addition of nortriptyline. The pulse rate rose in a parallel fashion. Pupil size, salivation and handwriting were diminished by chlorpromazine, but hardly affected further by nortriptyline. The addition of nortriptyline dramatically reversed the therapeutic actions of chlorpromazine, mainly through pharmacodynamic interaction. It is concluded that this combination is potentially deleterious, and must be used with care.
Our primary question was whether a telephone survey of restaurant personnel could provide accurate community-level measures of the restaurant health promotion environment. An obvious concern was that restaurant personnel might exaggerate the extent to which their establishment had a positive health promotion environment. Comparison with the most obvious "gold standard"--direct observation--showed fairly accurate reporting about nonsmoking seating arrangements, but restaurant personnel exaggerated the extent to which menu items were designated as low in fat. We also compared the restaurant-survey measures of nonsmoking seating availability at the community level with measures of the restrictiveness of local no-smoking ordinances. We found a positive relationship, as expected, between measures of the restrictiveness of ordinances and the amount of nonsmoking seating indicated by the restaurant survey.
We examined factors associated with participation in an HMO-based, self-help smoking cessation trial by comparing participants with nonparticipating smokers who responded to a prior health survey. Recruitment to the trial was accomplished through the HMO's monthly magazine sent to all enrollee households, and the health survey involved a random sample of the enrollee population. Participants were more likely to be female, older, better educated, and heavier smokers with more attempts to quit in the past. Participants consistently reported poorer levels of health status (self-perceived health and energy, life satisfaction, depression, and symptoms), less healthy lifestyles (exercise and dietary fat), and a greater conviction that smoking cessation would improve how they feel than nonparticipants. These findings confirm previous suggestions that formal cessation programs attract those with a more extensive history of addiction, prior failure, and pathophysiologic effects and may provide clues to increasing motivation among smokers with a greater likelihood of treatment success.
We examined the relationship of smoking history, motivation, social support, and stress to initial cessation and long-term abstinence in a sample of 402 smokers who participated in a worksite smoking cessation program. Compared to nonquitters, smokers who initially stopped smoking expected less difficulty quitting, had previously abstained for longer periods, and had a higher desire to quit. Long-term abstainers were lighter smokers and had more social support and less stress than relapsers. The differences in the predictors of initial cessation and long-term abstinence support the concept of a staged cessation process. The results suggest that intraindividual factors are particularly important early in the process, whereas environmental factors are more important during the later, maintenance stage. These findings are consistent with a biopsychosocial model of cessation and relapse and support multicomponent interventions.
This worksite study assesses the relative effectiveness of three smoking cessation programs. Computerized medical files indicated that 29% of 13,171 employees were current smokers. Of smokers responding to a worksite-wide survey, 79% indicated interest in a smoking cessation program; 402 smokers agreed to participate and were randomly allocated, within their preference for a group or self-help approach, to the three different programs. Overall, 11% of smokers participated, an excellent rate for a large worksite. Participants were followed for 12 months (91% follow-up). Smokers in the group preference had better short-term results than did those following the self-help approach. The Multiple Component Program had 61% who quit, the Relapse Prevention Program had 37%, and the American Cancer Society Quitter's Guide had 12%. Long-term quit rates ranged from 16% to 26%; all groups exceeded the usual spontaneous quit rate of 5%.