Biomedical subjects

S Csata

Publications and source records attributed to S Csata.

At least 19 recordsLinked to original sources

PubMed1999

[Schistosomiasis of the bladder].

Authors review a case of urinary schistosomiasis, where the process caused left sided urinary obstruction. Because of the suspicion of a tumor transurethral resections was performed, where after the ureter passage became unhindered. Diagnosis became clear upon the histological examination of the resected tissue. Based on the cited literature, reference is made to the mortality rate of the disease in the expanded endemic areas, as well as to the high number of patients at risk. A brief summery is given of the pathology, symptoms, diagnostics of the disease, with mention of differentiation and therapeutic possibilities as well. With regard to importation of the disease, attention is called to the importance of careful anamnesis.

Adult↗

PubMed1999

[Retroperitoneal malignant fibrous histiocytoma].

Authors review the case history and follow-up of a rare malignant fibrous histiocytoma patient, based on the relevant literary data. The tumor filled the retroperitoneum on the right side, in front of the right kidney. Intravenous urography and computer tomography revealed a 10 x 15 cm sized mass, suspect of being a kidney tumor. Upon surgery, the tumor was found to be a retroperitoneal malignant fibrous histiocytoma. In connection to the case, a brief review is given of the storiform type of malignant fibrous histiocytoma, regarding its etiological, clinical and pathological aspects, the difficulties in diagnosis, as well as the therapeutic possibilities. Authors regard their case worthy of publication because of the retroperitoneal location and significant size of the tumor, and because of the unproven diagnosis prior to surgery. Even after 4 years the patient is symptom- and complaint-free, and CT has revealed no metastases.

Aged↗

PubMed1998

[Renal oncocytoma].

Authors review the case history of three patients with kidney tumours which had been surgically removed. In two of the cases radical nephrectomy while in one, organ-preserving surgery was performed. In all three cases histology revealed benign kidney tumours-oncocytomas. In light of the available literature authors indicate that preoperative diagnosis is almost impossible. Furthermore, it is their opinion that this benign kidney tumour has a less frequent occurrence than earlier thought.

Adenoma, Oxyphilic↗

PubMed1998

Prostatic leiomyosarcoma.

The histopathological findings from the third prostate operation of a 63-year-old patient proved that his leiomysarcoma was malignant. Leiomyosarcoma is a disease of low incidence. Of 1000 cases of a carcinoma of prostate one proves to be this disease. Its clinical distinction from benign prostate disease meets difficulties. A survey of literature has shown that even multiple aggressive therapy fails when the process has overpassed the limits of the organ. Early diagnosis followed be radical pre- and postoperative X-irradiation may lead to long-term survival. Neither cytostatic nor hormonal therapy is successful. The course of the illness of our patients merits interest because of the rarity of the disease and the diagnostic difficulties.

Humans↗

PubMed1998

Spontaneous (renal) pelvic rupture. Two cases cured by conservative therapy.

Two cases of spontaneous pelvic rupture are presented. In Case 1 (female, 49 years) and Case 2 (male, 63 years) the rupture was due to obstruction and tumorous compression of the ureter, respectively. Authors deal with the diagnostic difficulties and the possibility of a cure without open surgery. Conservative therapy (double-J ureteral catheter and pigtail catheter) was successful in both cases. The pertinent literature is briefly reviewed.

Catheterization↗

PubMed1998

Ureter and bladder replacement following radical cystectomy.

During the course of Hautmann-type bladder replacement, left sided ureter damage necessitated ureter replacement as well, modifying the removal of the ileum-bladder. The proximal 20 cm length of the 70 cm long isolated ileum portion was not detubularized; instead it was slipped through the mesosigma and mesocolon to the left side of the colon and the left ureter stub was anastomized without tautness to the ileum according to Le Duc. The implantation of the right ureter was accomplished according to Hautmann. For similar cases authors recomment this procedure, since neither stricture, nor reflux could be detected at later examinations.

Aged↗

PubMed1998

Organ-preserving surgery of renal cell carcinoma: report of four cases.

Authors removed the renal tumour of four patients by means of resection in an organ-preserving manner. Of the four patients, one had bilateral carcinoma. The right-sided carcinoma of this patient was removed by resection while the other kidney was removed radically, by transabdominal approach. In three of the four cases which were in the process of stages T1 and N0M0, organ-preserving surgery was performed in the presence of intact opposite kidneys. Authors point out the fact that the resection method might be indicated even in the case of early (T1) stage tumours with intact opposite side kidneys. Furthermore, they do not recommend the enucleation of renal carcinomas for the surgical treatment of kidney tumours, since experimental studies have proved that these tumours can be transferred into the parenchyma of the kidney through the pseudocapsule of the tumour.

Adenocarcinoma, Clear Cell↗

PubMed1998

Bilateral ureteric replacement with ileum.

In connection with a report of a case, authors discuss in outline the possibilities of ureter replacement. If both the ureters are injured, they can be substituted with one single segment of the intestine, as it happened in their case. Authors raise the idea that a longer segment of the intestine used for substitution provides sufficient capacity and isoperistaltic function, and this may protect from the negative effects of possible vesicoileal reflux. In this case, the reflux does not spread to the kidneys even if the ureteroileal was not made with anti-reflux technique.

Anastomosis, Surgical↗

PubMed1998

Kidney oncocytoma.

Authors review the case history of three patients with kidney tumours which had been surgically removed. In two of the cases radical nephrectomy while in one, organ-preserving surgery was performed. In all the cases histology revealed benign kidney tumours--oncocytomas. In light of the available literature authors indicate that preoperative diagnosis is almost impossible. Furthermore, it is their opinion that this benign kidney tumour has a less frequent occurrence than earlier thought.

Adenoma, Oxyphilic↗

PubMed1998

Experiences of 25 orthotopic ileal neobladders.

Authors report on their results obtained from orthotopic ileal neobladders following 25 cases of radical cystectomy. Analysis is given of the possible complications, their prevention, as well as of surgical techniques. It is determined that orthotopic ileal neobladder is one of the best bladder substitution methods, giving the patient a chance for a high quality of life.

Aged↗

PubMed1998

Experiences on 25 cases of radical cystectomy.

Authors review their early experiences and the oncopathological relations in respect to 25 cases of radical cystectomy involving orthotopic bladder substitution. The difficulties of diagnostics and indication are discussed. Attention is drawn to the fact that pathological "staging", "grading" are not entirely exact and reliable, though surgical indication is positioned on these. It is the opinion of authors that in case of TIG3 radical surgery is indicated. Due to the shortness of the follow-up periods, no studies on survival were performed. It remains an open question whether radical cystectomy is indicated as opposed to the possible choice of organ-preserving surgery.

Aged↗

PubMed1998

Schistosomiasis of the urinary bladder.

Authors review a case of urinary schistosomiasis, where the process caused left-sided urinary obstruction. Because of the suspicion of a tumor transurethral resection was performed, whereafter the ureter passage became unhindered. Diagnosis became clear upon the histological examination of the resected tissue. Based on the cited literature, reference is made to the mortality rate of the disease in the expanded endemic areas, as well as to the high number of patients at risk. A brief summary is given of the pathology, symptoms, diagnostics of the disease, with mention of differentiation and therapeutic possibilities as well. With regard to importation of the disease, attention is called to the importance of careful anamnesis.

Adult↗

PubMed1998

Retroperitoneal malignant fibrous histiocytoma.

Authors review the case history and follow-up a rare malignant fibrous histiocytoma patient, based on the relevant literary data. The tumor filled the retroperitoneum on the right side, in front of the right kidney. Intravenous urography and computer tomography revealed a 10 x 15 cm sized mass, suspect of being a kidney tumor. Upon surgery, the tumor was found to be a retroperitoneal malignant fibrous histiocytoma. In connection to the case, a brief review is given of the storiform type of malignant fibrous histiocytoma, regarding its etiological, clinical and pathological aspects, the difficulties in diagnosis, as well as the therapeutic possibilities. Authors regard their case worthy of publication because of the retroperitoneal location and significant size of the tumor, and because of the unproven diagnosis prior to surgery. Even after 4 years the patient is symptom- and complaint-free, and CT has revealed no metastases.

Aged↗

PubMed1998

Studies on tumourous and other urogenital patients with respect to antigens of oncogenic adenovirus.

The possible connection of viruses with tumours was investigated by serologic examinations. Concerning the presence of antibodies against adenoviruses, especially those against the early non-virion antigens of oncogenic adenovirus type 12, approximately 4000 tests were made with sera of 446 urogenital patients with and without tumours and 70 ones with internal diseases. It was found by complement fixation tests that antibodies against nonvirion antigens of adenoviruses were present in 53% of urogenital patients suffering from malignant tumours and prostatic hypertrophy, in 18% of non-tumourous urological patients and in 4% of patients with internal diseases, respectively. The results suggest that adenoviruses may play a role in tumourous diseases of the urogenital organs.

Adenoviruses, Human↗

PubMed1994

Transfected lymphocyte extracts of patients with urological tumours: complement temperature-sensitive adenovirus mutants in vitro.

Patients with renal or bladder cancers exhibit a unique association with adenovirus (Ad) infections. About 60% of them contain antibodies to Ad early antigens. Both in their tumour cells and peripheral blood lymphocytes (PBL) they have detectable early Ad antigens known to be involved in malignant cell transformation. Transfection of tumour cell extracts resulted in complementing temperature-sensitive (ts) Ad mutants at nonpermissive temperatures (39 degrees C) indicating that some cells of the tumour mass possess active functions for Ad. Only 4 to 18% of control subjects were positive in these tests. Here we studied whether lymphocytes might be involved in tumourigenesis by Ad. PBL extracts of patients were transfected into HEp-2 culture cells, which were subsequently superinfected with Ad-5 ts18 and ts19 mutants at 39 degrees C. Titration of virus yields indicated complementation in 76% of patients with renal and bladder cancers in contrast to 20% of control individuals. Complementing ability of lymphocytes which had been prestimulated with phytohaemagglutinin (PHA) approached that of tumour extracts. It means that both specimens contain advanced functions in contrast to resting lymphocytes. Lymphocytes are nonpermissive for latently carried Ad infections. Expression, possible transfer of early Ad gene products via frequent contacts with tissue cells can result in removal of tumour suppressor gene products from complexes regulating cell cycle negatively. Further interaction with hormone-sensitive protooncogenes explains tissue, age and gender specificity of urological malignancies. These phenomena suggest an important cofactorial role for Ad in kidney and bladder tumours.

Adenoviruses, Human↗

PubMed1993

Follow-up of the effect of BCG vaccine treatment in bladder tumour patients.

The effect of intravesical BCG vaccine treatment in 38 patients with superficial bladder tumour after TUR (Transurethral Resection) was followed by the lymphocyte transformation test (LTT) and the staphylococcus phagocytosis test of in vitro washed leukocytes. The results have confirmed the immunostimulating and hence anti-tumour effect of intravesical BCG vaccine. Monitoring of the cellular immune response is suitable for the continuous follow-up of the BCG effect. Comparing the tolerable side-effects with their favourable therapeutic results, BCG vaccine is considered to be effective for the prevention of recurrences in treating superficial bladder tumours.

BCG Vaccine↗

PubMed1992

Use of pefloxacin in urogenital infections.

Forty-three patients suffering from acute or chronic urinary tract infections have been treated with pefloxacin at the Department of Urology of St. Istán Hospital. Twenty-three patients received oral doses (2 x 400 mg), 1 tabl. in the mornings and 1 in the evenings. Eighteen patients were given 2 x 1 intravenous ampoule (2 x 400 mg) dissolved in 250 ml 5% glucose in slow drip infusion. Both the oral and intravenous doses were given in the patients for 10 days. In two patients complications was observed--in one case rhagades were formed on the lip and face due to photo-sensibilization, in the other case the drug administration had to be discontinued because of nausea and vomiting. These symptoms ceased after the discontinuance of the drug. The clinical conditions, the routes of administration, clinical and bacteriological results are summarized in tables. On the basis of a low number of cases it has been concluded that pefloxacin is a new valuable antibacterial drug the use of which resulted in recovery in 15 out of 18 patients' acute and chronic infections of the urogenital system.

Administration, Oral↗

PubMed1991

Virus-host studies in human seminal and mouse testicular cells.

Virological studies were performed for male infertility and repeated abortions. It was found that in about 40% of infertile males infectious adeno- or herpes simplex virus is present in the semen, while the same viruses are present in 60% of the cells in a latent form. In the aborted fetuses the same viruses could be observed as in the father's cells. Due to semen added to tissue cultures the latent presence also of other viruses could be supposed. The affinity of adeno- and herpes viruses to urogenital organs was confirmed by animal experiments, where a new method was applied for in vivo infection. The close correlation between viruses and urogenital cells was similarly confirmed by infecting in vitro human seminal and testicular cells with adeno- and herpes simplex viruses absorbed by the cells, entering them, moreover replicating in the form of their components. Based on the results, it was assumed that chronic local urogenital infections, due to various viruses, may play a role in male infertility and in a part of repeated abortions by damaging their cells. Applying a Zovirax therapy, the seminal cells were stopped to be viral carriers and normal function was restored.

Abortion, Habitual↗